CAS: 316173-57-6; 2-(Furan-2-yl)-7-(3-(4-Methoxyphenyl)Propyl)-7H-Pyrazolo[4,3-E][1,2,4]Triazolo[1,5-C]Pyrimidin-5-Amine

上下游产品

7-[3-(3,4-Dimethoxy)-Phenylpropyl]-2-(2-Furyl)Pyrazolo[4,3-E]-1,2,4-Triazolo[1,5-C]Pyrimidine 316173-62-3
Furan-2-Carboxylic Acid {4-Imino-1-[3-(4-Methoxy-Phenyl)-Propyl]-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl}-Amide 1026405-82-2
5-Amino-1-[3-(4-Methoxy)Phenylpropyl]-4-[3-(2-Furyl)-1,2,4-Triazol-5-Yl]Pyrazole 316173-63-4

📜1-(3-氯丙基)-4-甲氧基苯置于n-甲基吡咯烷酮,盐酸,对甲苯磺酸,三乙胺,肼体系中,用 1,4-二氧六环,二苯醚,乙醇,乙二醇甲醚 用作溶剂,化学反应 110.5H,反应生成2-(2-呋喃基)-7-[3-(4-甲氧基苯基)丙基]-7H-吡唑并[4,3-E][1,2,4]噻唑并[1,5-C]嘧啶-5-胺
参考文献:Design,Radiosynthesis,And Biodistribution Of A New Potent And Selective Ligand For In Vivo Imaging Of The Adenosine A2A Receptor System Using Positron Emission Tomography
标题:Design,Radiosynthesis,And Biodistribution Of A New Potent And Selective Ligand For In Vivo Imaging Of The Adenosine A2A Receptor System Using Positron Emission Tomography
摘要:
Doi:10.1021/jm0009843

专利信息

专利号:WO-2012127472-A1
优先权日:2011-03-22
标题:Process and intermediates for the preparation of preladenant and related compounds
发明人：MAROM EHUD; MIZHIRITSKII MICHAEL; RUBNOV SHAI
权利人:MAPI PHARMA LTD; MAROM EHUD; MIZHIRITSKII MICHAEL; RUBNOV SHAI
摘要:The present invention describes processes for the synthesis of 2-(furan-2-yl)-7-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-l-yl] ethyl]-7H-pyrazolo[ 4,3-e ][1,2,4]- triazolo[1,5c] pyrimidin-5-amine (Preladenant) represented by the structure of formula (1 ), and solvates and salts thereof, especially salts with pharmaceutically acceptable acids. The process of the present invention is useful not only for Preladenant production, but also for the preparation of other biologically active compounds of general formula (17), such as A2a receptor antagonists used for the treatment of central nervous system diseases, among others. The present invention further relates to certain intermediates formed in such processes.

专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.