CAS: 314-13-6; Sodium 6,6'-((3,3'-Dimethyl-[1,1'-Biphenyl]-4,4'-Diyl)Bis(Diazene-2,1-Diyl))Bis(4-Amino-5-Hydroxynaphthalene-1,3-Disulfonate)

专利信息

专利号:US-6201168-B1
优先权日:1999-08-20
标题:Pathogenesis of cardiomyopathy
发明人：CAMPBELL KEVIN P; CORAL RAMON; COHN RONALD; WILLIAMSON ROGER; DURBEEJ MADELEINE
权利人:UNIV IOWA RES FOUND
摘要:Disclosed is a mouse, cells derived therefrom, and methods for using the mouse, the mouse being homozygous for a disrupted δ-sarcoglycan gene, the disruption in the gene having been introduced into the mouse or an ancestor of the mouse at an embryonic stage. The disruption prevents the synthesis of functional δ-sarcoglycan in cells of the mouse and results in the mouse having a reduced amount of β- and ε-sarcoglycan and sarcospan, and a disruption of the sarcoglycan-sarcospan complex in smooth muscle of the mouse. Also disclosed is a mouse, cells derived therefrom, and methods for using the mouse, the mouse being homozygous for a disrupted β-sarcoglycan gene, the disruption in the gene having been introduced into the mouse or an ancestor of the mouse at an embryonic stage. The disruption prevents the synthesis of functional β-sarcoglycan in cells of the mouse and results in the mouse having a reduced amount of δ-and ε-sarcoglycan and sarcospan and α-dystroglycan in smooth muscle of the mouse.

专利号:WO-9619572-A1
优先权日:1994-12-22
标 题:Synthesis of stereospecific oligonucleotide phosphorothioates
发明人：TANG JINYAN; ROSKEY ALLYSEN M; AGRAWAL SUDHIR
权利人:HYBRIDON INC; TANG JINYAN; ROSKEY ALLYSEN M; AGRAWAL SUDHIR
摘要:Disclosed is a method for synthesizing of stereospecific (Rp) phosphorothioate oligonucleotides. In this method, a primer comprising a plurality of deoxyribonucleotides and a ribonucleotide at the 5' terminal or 5' penultimate position, is annealed to a template. The structure is contacted with a mixture of deoxynucleoside α-triphosphate Sp diastereomers and a DNA polymerase to form a PS-Rp oligodeoxynucleotide extension which is liberated as a single-stranded PS-Rp oligonucleotide by cleavage after the ribonucleotide in the primer. Also disclosed are PS-Rp oligonucleotides and oligonucleotides prepared according to this method.

专利号:WO-9700244-A1
优先权日:1995-06-19
标题 :Process for parallel synthesis of a non-peptide library
发明人：FRITZ JAMES E; KALDOR STEPHEN W
权利人:LILLY CO ELI; FRITZ JAMES E; KALDOR STEPHEN W
摘要:A process for the sequential preparation of a library of compounds having pharmaceutical usage. The process involves the sequential mixing of solution phase reagents, followed by scavenging of excess unreacted reagents with solid phase scavenging agents. The process is highly iterative and applicable for producing various ureas, thiureas, amides, carbonates and tertiary amines.

专利号:US-10849901-B2
优先权日:2014-05-27
标题 :Arf6 inhibitors and methods of synthesis and use thereof
发明人：OSTANIN KIRILL; SHENDEROVICH MARK; BAJJI ASHOK; CIOFFI CHRISTOPHER L; MOSS NEIL; VANKAYALAPATI HARIPRASAD; LI DEAN
权利人:NAVIGEN INC; THE UNIV OF UTAH RESEARCH FOUNCATION; THE UNIV OF UTAH RESEARCH FOUNDATION
摘要:Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.

专利号:US-5876962-A
优先权日:1987-08-12
标题:Expression vectors for the synthesis of proteins and plasmid replicons and sequence cassettes for use in constructing such vectors
发明人：BISHOP DAVID H L; EMERY VINCENT CLIVE
权利人:NATURAL ENVIRONMENT RES
摘要:Expression vectors for the expression of proteins, particularly eukaryotic proteins are provided which are based on novel plasmid replicons. Sequence cassettes useful in constructing such vectors are also disclosed. The expression vectors according to the invention are useful for expressing selected proteins in insects and insect cells. Specifically, the plasmid replicons comprise double-stranded DNA having (a) one or more sequences allowing the replicon to be reproduced in a bacterial host, (b) first and second sequences which are adapted to permit an intervening sequence located between said first and second sequences to be introduced into an expression vector, and (c) an intervening sequence located between said first and second sequences, and are characterised in that the intervening sequence comprises first and second polypeptide expression sequences (PESs) wherein each PES includes (i) a transcriptional promotor (ii) a unique restriction site for introduction of a gene which is native or foreign to the expression vector and (iii) a transcriptional termination site.

专利号:EP-0327626-B1
优先权日:1987-08-12
标 题:Expression vectors for the synthesis of proteins and plasmid replicons and sequence cassettes for use in constructing such vectors
摘要:Expression vectors for the expression of proteins, particularly eukaryotic proteins are provided which are based on novel plasmid replicons. Sequence cassettes useful in constructing such vectors are also disclosed. The expression vectors according to the invention are useful for expressing selected proteins in insects and insect cells. Specifically, the plasmid replicons comprise double-stranded DNA having (a) one or more sequences allowing the replicon to be reproduced in a bacterial host, (b) first and second sequences which are adapted to permit an intervening sequence located between said first and second sequences to be introduced into an expression vector, and (c) an intervening sequence located between said first and second sequences, and are characterised in that the intervening sequence comprises first and second polypeptide expression sequences (PESs) wherein each PES includes (i) a transcriptional promotor (ii) a unique restriction site for introduction of a gene which is native or foreign to the expression vector and (iii) a transcriptional termination site.