CAS: 300657-03-8; 2-((2'-(5-Ethyl-3,4-Diphenyl-1H-Pyrazol-1-yl)-[1,1'-Biphenyl]-3-yl)Oxy)Acetic Acid

化学文摘社编号:300657-03-8),是复杂的有机化合物,含有乙酸味,有助于其酸性,以及代之以双联苯组的双子环,表明由于其芳香性质,有可能发生多种相互作用.乙基和苯基组的存在表明,该化合物可能表现出疏水恐特性,影响其溶性与再活性.由于其潜在的生物活动和结构复杂性,该化合物的合成和应用可能涉及其稳定性,再活性和与其他化学实体的相互作用.

结构式图片

物理性质

MSDS等安全信息

上下游产品

Ethyl 2-[3-[2-(5-Ethyl-3,4-Diphenylpyrazol-1-yl)Phenyl]Phenoxy]Acetate 1003863-73-7
2-(5-乙基-3,4-二苯基-吡唑-1-基)-联苯-3-醇 2'-(5-Ethyl-3,4-Diphenyl-1H-Pyrazol-1-yl)Biphenyl-3-Ol 710354-39-5
1-(2-溴苯基)-5-乙基-3,4-二苯基-1H-吡唑 1-(2-Bromophenyl)-5-Ethyl-3,4-Diphenyl-1H-Pyrazole 300658-42-8

合成工艺路线路线简述

    📜Ethyl 2-[3-[2-(5-Ethyl-3,4-Diphenylpyrazol-1-yl)Phenyl]Phenoxy]Acetate置于sodium Hydroxide体系中,用88%的收率获得2-(5-乙基-3,4-二苯基-吡唑-1-基)-联苯-3-基氧基]乙酸
    参考文献:Potent And Selective Biphenyl Azole Inhibitors Of Adipocyte Fatty Acid Binding Protein (Afabp)
    标题:Potent And Selective Biphenyl Azole Inhibitors Of Adipocyte Fatty Acid Binding Protein (Afabp)
    摘要:Herein We Report The First Disclosure Of Biphenyl Azoles That Are Nanomolar Binders Of Adipocyte Fatty Acid Binding Protein (Afabp Or Ap2) With Up To Thousand-Fold Selectivity Against Muscle Fatty Acid Binding Protein And Epidermal Fatty Acid Binding Protein. In Addition A New Radio-Ligand To Determine Binding Against The Three Fatty Acid Binding Proteins Was Also Synthesized. (C) 2007 Elsevier Ltd. All Rights Reserved.
    Doi:10.1016/j.Bmcl.2006.12.044

    海关参考信息

    专利信息


    专利号:US-7300639-B2
    优先权日:2002-12-03
    标 题:Process for removing metals from liquids
    发明人：LIU WANSHENG
    权利人:BRISTOL MYERS SQUIBB CO
    摘要:A process is provided for removing one or more metals from liquids. Also provided is a process for the synthesis of aP2 inhibiting compounds having the formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , HET, and X-Z are as described herein, which process comprising the step of removing one or more metals from a solution of the compound of formula I or an intermediate or precursor thereof. The processes for removing metal comprise the step of contacting the liquid with a solid extractant comprising a metal-binding functionality.

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    主要参考文献


    1: Yao F, Li Z, Ehara T, Yang L, Wang D, Feng L, Zhang Y, Wang K, Shi Y, Duan H, Zhang L. Fatty Acid-Binding Protein 4 mediates apoptosis via endoplasmic reticulum stress in mesangial cells of diabetic nephropathy. Mol Cell Endocrinol. 2015 Aug 15;411:232-42. doi: 10.1016/j.mce.2015.05.003. Epub 2015 May 6. doi: 10.1016/j.atherosclerosis.2015.03.042. Epub 2015 Apr 3. doi: 10.1021/cn5002107. Epub 2014 Dec 3. doi: 10.1111/cbdd.12440. Epub 2014 Oct 16.
    5: Sanson B, Wang T, Sun J, Wang L, Kaczocha M, Ojima I, Deutsch D, Li H. Crystallographic study of FABP5 as an intracellular endocannabinoid transporter. Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):290-8. doi: 10.1107/S1399004713026795. Epub 2014 Jan 29.
    6: Kralisch S, Ebert T, Lossner U, Jessnitzer B, Stumvoll M, Fasshauer M. Adipocyte fatty acid-binding protein is released from adipocytes by a non-conventional mechanism. Int J Obes (Lond). 2014 Sep;38(9):1251-4. doi: 10.1038/ijo.2013.232. Epub 2013 Dec 13. doi: 10.1016/j.bmcl.2013.01.054. Epub 2013 Jan 26. doi: 10.1021/cn3000873. Epub 2012 Sep 22.

    合成参考文献


    参考文献:10.1007/s00210-011-0667-1
    摘要:Look C, Morano I, Ehrhart-Bornstein M, Bornstein SR, Lamounier-Zepter V. BMS309403 directly suppresses cardiac contractile function. Naunyn Schmiedebergs Arch Pharmacol. 2011 Sep;384(3):255–63. doi: 10.1007/s00210-011-0667-1.
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