CAS: 18721-64-7; Diethyl 2-(2-Bromoethyl)Malonate
该化合物是一种溴化二乙基衍生物,在有机合成中用作多种用途的电镀剂,其结构具有反应性2-溴乙基组,能够产生有效的核循环替代反应,特别是在准备三环化合物和功能性甲状腺时.二乙基酯会提高有机溶剂的溶解性,便于合成工作流程的处理.该化合物因其能够将溴乙基功能引入目标分子,作为制药,农用化学品和特殊化学品的关键中间体而备受珍视.在标准储存条件下,其稳定性和有详细记录的再活性简介使该化合物成为复杂的合成变异的可靠试剂.
- 英文名称Diethyl 2-(2-Bromoethyl)Malonate
- 中文名称卡博替尼杂质HF
- IUPAC名称diethyl 2-(2-bromoethyl)malonate
- 其它别名Cabozantinib Impurity Hf; Propanedioic Acid, 2-(2-Bromoethyl)-, 1,3-Diethyl Ester; Diethyl 2-(2-Bromoethyl)Malonate; Diethyl 2-(2-Bromoethyl)Malonate? (Cabozantinib Impurity）
- CAS编号18721-64-7
- MFCD编号:MFCD02258515
- EINECS号:887-388-2
- 分子式:C9H15BrO4分子量:267.12
- 产品CID: 952820
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
MSDS等安全信息
欧盟法规
C&L通报上下游产品
1,1-环丙基二羧酸二乙酯 Diethyl Cyclopropane-1,1-Dicarboxylate 1559-02-0合成工艺路线路线简述
- 合成目标产物 Diethyl 2-(2-Bromoethyl)-Malonate 主要起始原料 Diethyl 1,1-Cyclopropanedicarboxylate
- (文献来源)合成步骤主要原料 Diethyl 1,1-Cyclopropanedicarboxylate
📜1,1-环丙基二羧酸二乙酯置于氢溴酸体系中,用95%的收率获得卡博替尼杂质hf
参考文献:Epr研究1,1-双(烷氧羰基)烷基和三(乙氧羰基)甲基与烯烃和烷基异氰酸酯的加成反应
标题:Epr研究1,1-双(烷氧羰基)烷基和三(乙氧羰基)甲基与烯烃和烷基异氰酸酯的加成反应
摘要:Epr光谱学已用于监测加成rc(co的2 Et)2(r = H或me)和c(co的2 Et)3到末端烯烃,呋喃,Menc和bu吨nc在低温环丙烷溶液温度.二-通过uv产生的自由基光解附加物叔相应的丙二酸酯或三乙基甲三羧酸三乙酯与三甲胺-丁基硼烷络合物的存在下,生成的过氧化丁酯可作为极性逆转催化剂,用于从酯中缺乏电子的α-C-H基团中夺取氢原子.对于所有受体,每个亲电α-烷氧基羰基(烷基)基团的添加比相应的简单(亲核)烷基基团的添加更快,其结果归因于在过渡态下电荷转移相互作用的重要性(极地影响).此外hc(co的相对速率2的et)2,Mec(co 2 Et)2和c(co 2 Et)3至h 2 ç Ch参照图2,Mechch 2,Me 2 Chch 2和me 3 Sich 2 Chch 2也主要受极性效应支配.在221 K下向乙烯中添加hċ(co 2 Et) 2和˙c(co 2 Et) 3的近似绝对速率常数确定为7
Doi:10.1039/p29920001761
海关参考信息
- 2905121000-正丙醇
2905399001-1,3-丙二醇
2909110000-乙醚
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.
专利号:US-6011152-A
优先权日:1996-07-22
标 题 :Synthesis of macrocyclic tetraamido-N ligands
专利号:WO-2004076425-A1
优先权日:2003-02-21
标题:Improved synthesis of macrocyclic tetraamido compounds and new metal insertion process
