CAS: 17746-08-6; Pentadecanoylchloride

上下游产品

palmitic acid 1-bromotridecane oxalyl dichloride3-oxo-heptadecanoic acid methyl ester pentadecanoic acid[2,6-diethyl-2,3,6-trimethyl-1-(1-phenyl-ethoxy)-piperidin-4-yl]-amide 1-(2,5-dimethoxy-phenyl)-pentadecan-1-one 1-phenylpentadecan-1-one

📜十五烷酸置于氯化亚砜体系中,化学反应 3.0H,反应生成十五烷酰氯
参考文献:8-氮杂萘啶衍生物对面包酵母和猪肝脏中的2,3-氧化角鲨烯:羊毛甾醇环化酶的抑制活性.
标题:8-氮杂萘啶衍生物对面包酵母和猪肝脏中的2,3-氧化角鲨烯:羊毛甾醇环化酶的抑制活性.
摘要:通过猪肝和贝克酵母的对比研究,研究了2,3-氧化角鲨烯:羊毛甾醇环化酶的抑制剂.抑制剂的基本骨架是8-Azadecalin.通过与nacnbh 3的还原胺化反应,将异戊二烯样链[神经节丙酮(z-形式),香叶基丙酮(e-形式)或其氢化形式]连接到氮原子上.在这三种形式中,Z-异构体是对猪肝脏和酵母环化酶最有效的抑制剂.为了检查碳链长度(亲脂性)的影响,将各种脂肪酸(c6-C18)附加到8-Azadecalin衍生物上.对于在c12附近具有碳链的那些化合物,观测到强的抑制活性.有趣的是 酰胺化合物(不是碳正离子中间体)对肝脏环化酶表现出显着的抑制作用,而对酵母环化酶的作用却微不足道(活性降低约10(2)倍).酵母环化酶需要胺官能团(碳酸盐中间体),该胺官能团是通过使用lialh4从相应的酰胺中制备的,以表现出有效的抑制作用.我们发现,在任何已知物质中,N-十二烷基-8-氮杂-4,4,10β-三
Doi:10.1271/bbb.59.602

专利信息

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-5945559-A
优先权日:1996-05-24
标题:Process for producing 3-oxocarboxylic acid esters
发明人：SOTOGUCHI TSUKASA; YUASA YOSHIFUMI; TACHIKAWA AKIO; HARADA SHUNICHI
权利人:TAKASAGO PERFUMERY CO LTD
摘要:A novel process for producing 3-oxocarboxylic acid esters, which are useful as intermediates in the synthesis of ceramides to be used as a humectant, biodegradable polymers, drugs, etc., at a high purity and a high yield without requiring any troublesome procedure, is disclosed. The process comprises reacting an acetoacetic ester with a calcium compound, a barium compound or a strontium compound in the presence of an organic solvent at a temperature of 10 to 120 DEG C., further reacting the obtained product with a carboxylic acid chloride to thereby acylate it, and then adding thereto an alcohol in an amount 1 to 5 times by mol as much as the calcium compound, barium compound or strontium compound to thereby deacetylate the same.