CAS: 17529-98-5; N'-Cyclopentylidene-4-Methylbenzenesulfonohydrazide

上下游产品

CAS号120-92-3 环戊酮 | CAS号1576-35-8 对甲苯磺酰肼 | CAS号5422-88-8 苯基环戊基酮 | CAS号14579-07-8 cyclopenten-1-y... | CAS号287944-10-9 2-(1-环戊基)-4,4,5... | CAS号287-92-3 环戊烷 | CAS号6140-65-4 1-环戊烯甲醛 | CAS号56382-73-1 5,6-dihydro-4H-...

环戊酮,对甲苯磺酰肼 以 乙醇 用作溶剂,以88%的收率获得环戊酮对甲苯磺酰腙
参考文献:通过亚磷酸酯与杂环腙的加成合成新的 (3-Aminopyrrolidin-3-yl) 膦酸-一种葫芦素类似物-和 (3-Aminotetrahydrothiophen-3-yl) 膦酸
标题:通过亚磷酸酯与杂环腙的加成合成新的 (3-Aminopyrrolidin-3-yl) 膦酸-一种葫芦素类似物-和 (3-Aminotetrahydrothiophen-3-yl) 膦酸
摘要:腙是通过碳环杂环酮与 Denzoyana 甲苯磺酰肼缩合制备的.这些腙与亚磷酸酯进行亲核加成以有效地提供 (3-肼基吡咯烷-3-基)-,(3-肼基四氢噻吩-3-基)-,(3-肼基四氢呋喃-3-基)-和(1-肼基环戊基)膦酸盐. 肼 Nn 键断裂,然后酸水解 (3-氨基杂环戊基) 膦酸盐的膦酸盐官能团,得到新的 (3-氨基吡咯烷-3-基)-和 (3-氨基四氢噻吩-3-基)膦酸.该合成是从适当的酮以四步顺序实现的.
Doi:10.1055/s-2008-1067130

专利信息

专利号:US-11613514-B2
优先权日:2016-03-25
标题:Crystal forms and methods of synthesis of (2R, 6R)-hydroxynorketamine and (2S, 6S)-hydroxynorketamine
发明人：THOMAS CRAIG; ZARATE CARLOS; MOADDEL RUIN; GOULD TODD; ZANOS PANOS; MORRIS PATRICK
权利人:US HEALTH; UNIV MARYLAND
摘要:The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketamine (HNK) includes preparation of (R)-norketamine via chiral resolution from racemic norketamine via a chiral resolution with L-pyroglutamic acid. The disclosure also provided crystal forms of the corresponding (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine hydrochloride salts.

专利号:US-2023192594-A1
优先权日:2016-03-25
标题 :Crystal forms and methods of synthesis of (2r, 6r)-hydroxynorketamine and (2s, 6s)-hydroxynorketamine

专利号:US-10919842-B2
优先权日:2016-03-25
标 题 :Crystal forms and methods of synthesis of (2R, 6R)-hydroxynorketamine and (2S, 6S)-hydroxynorketamine

专利号:US-2019135732-A1
优先权日:2016-03-25
标 题:Crystal forms and methods of synthesis of (2r, 6r)-hydroxynorketamine and (2s, 6s)-hydroxynorketamine

专利号:US-2021139411-A1
优先权日:2016-03-25
标 题:Crystal forms and methods of synthesis of (2r, 6r)-hydroxynorketamine and (2s, 6s)-hydroxynorketamine

专利号:WO-2017165878-A1
优先权日:2016-03-25
标 题:Crystal forms and methods of synthesis of (2r, 6r)-hydroxynorketamine and (2s, 6s)-hydroxynorketamine