专利号:US-9650355-B2 优先权日:2013-01-31 标 题 :Method for preparation of justicidin a derivatives of arylnaphthalene lignan structure 发明人:HAM JUNGYEOB; KIM TAE JUNG; KWON HAK CHEOL; JEONG KYU HYUK; SONG JUNGHO; CHUNG BONG CHUL 权利人:KOREA INST SCI & TECH 摘要:The present disclosure relates to a novel method for preparing an arylnaphthalene lignan compound. In synthesis of arylnaphthalene lignan compounds and derivatives according to the present disclosure, a naphthalene backbone may be constructed first and an aryl group may be introduced at the final stage. Through this, various kinds of derivatives that could not be prepared from the existing methods can be synthesized effectively. Further, the synthesis method according to the present disclosure is appropriate for large-scale production.
专利号:WO-2012173572-A1 优先权日:2011-06-10 标 题 :Stereoselective synthesis of highly substituted enamides 发明人:PARK CHEOL-MIN; LIU YU 权利人:UNIV NANYANG TECH; PARK CHEOL-MIN; LIU YU 摘要:The disclosure provides new methods for the oxidative Heck cross-coupling reaction with electron-rich alkenes such as substituted β-amidoacrylate and other related substituted enamides. Previously, functionalization of enamides under Heck conditions has been limited to those with unsubstituted vinyl groups. By tuning the reaction parameters that allow for the balance between stability and reactivity of the reactants, the oxidative Heck cross-coupling reaction now provides highly substituted enamides in good to excellent yields. (II) (III) (I)·
专利号:US-7119212-B2 优先权日:2004-03-30 标 题 :Process for the preparation of tolterodine and intermediates thereof 发明人:COLOMBO LINO; ROSSI ROBERTO; ALLEGRINI PIETRO; CASTALDI GRAZIANO 权利人:DIPHARMA SPA 摘要:A process for the preparation of 6-methyl-4-(R)-phenyl-chroman-2-one and 6-methyl-4-(S)-phenyl-chroman-2-one, intermediates for the synthesis of tolterodine and its (S) enantiomer, by reaction of 6-methyl-coumarin with phenylboronic acids, esters and derivatives thereof, in the presence of chiral catalysts.
专利号:CN-119019314-B 优先权日:2024-09-26 标 题:Synthesis of Abediterol Precursors
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