专利号:US-9475757-B2 优先权日:2013-05-03 标 题 :Synthesis of anti-Parkinson agent 发明人:MUTHUKRISHNAN MURUGAN; MUJAHID MOHAMMAD 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to an improved process for synthesis of anti-Parkinson compound of formula (I) from commercially available (R)-benzyl glycidyl ether, wherein the compound obtained has enantiopurity greater than >98%. Formula (I) wherein R 1 and R 2 are each independently selected from hydrogen or halogen.
专利号:US-9284306-B2 优先权日:2012-05-11 标题 :(R)-Nifuratel, its use for the treatment of infections and synthesis of (R) and (S)-Nifuratel 发明人:GAGLIARDI STEFANIA; CONSONNI ALESSANDRA; MAILLAND FEDERICO; BULGHERONI ANNA 权利人:POLICHEM SA 摘要:(R)-Nifuratel is disclosed together with its use as bactericide and bacteriostatic agent as well as the pharmaceutical compositions containing the same; (R)-nifuratel has been surprisingly found to possess a better antimicrobial profile than either nifuratel racemate or (S)-nifuratel. A new procedure for the synthesis of both (R)-Nifuratel and (S)-Nifuratel is also disclosed.
专利号:US-5591852-A 优先权日:1990-08-10 标题 :Process for the preparation of nucleotides 发明人:VEMISHETTI PURUSHOTHAM; BRODFUEHRER PAUL R; HOWELL HENRY G; SAPINO JR CHESTER 权利人:ACAD OF SCIENCE CZECH REPUBLIC; REGA STICHTING 摘要:The present invention relates to a novel and economical process for the synthesis of HPMP-substituted nucleotide antiviral compounds. Also disclosed are novel intermediates produced in the process for the preparation of HPMPC.
专利号:US-7439364-B2 优先权日:2001-05-17 标 题 :Process for the synthesis of derivatives of halo-[2,3-F] quinoline 发明人:CHAN ANITA W; CURRAN TIMOTHY T; IERA SILVIO; CHEW WARREN; SELLSTEDT JOHN H; VID GALINA; FEIGELSON GREG; DING ZHIXIAN 权利人:WYETH CORP 摘要:Methods of preparing compounds of Formula I n nare provided.
专利号:US-8487108-B2 优先权日:2005-11-14 标题 :Piperidinyl carbamate intermediates for the synthesis of aspartic protease inhibitors 发明人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T 权利人:BALDWIN JOHN J; CLAREMON DAVID A; TICE COLIN; CACATIAN SALVACION; DILLARD LAWRENCE W; ISHCHENKO ALEXEY V; YUAN JING; XU ZHENRONG; MCGEEHAN GERARD; SIMPSON ROBERT D; SINGH SURESH B; ZHAO WEI; FLAHERTY PATRICK T; VITAE PHARMACEUTICALS INC 摘要:The present invention is directed to aspartic protease inhibitors. Certain aspartic protease inhibitors of the invention can be represented by the following structural formula or a pharmaceutically acceptable salt thereof. The present invention is also directed to pharmaceutical compositions comprising the disclosed aspartic protease inhibitors. The present invention is further directed to methods of antagonizing one or more aspartic proteases in a subject in need thereof, and methods for treating an aspartic protease mediated disorder in a subject using the disclosed aspartic protease inhibitors.
专利号:US-6417374-B1 优先权日:2001-02-15 标题 :Process for the preparation of beta hydroxy-delta lactone using novel intermediates 发明人:GHORPADE SANDEEP RAGHUNATH; KALKOTE UTTAM RAMRAO; CHAVAN SUBHASH PRATAPRAO; BHIDE SUNIL RAMCHANDRA; RAVINDRANATHAN THOTTAPPILLIL 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to a process for the preparation of optically active 6-hydroxymethyl-4-(tert-butyldimethylsilyloxy)-(4R,6S)-tetrahydro-2H-2-pyranone(β-Hydroxy-δ-lactone) an important intermediate in the synthesis of biologically active drugs e.g. compactin, atorvastatin, fluvastatin, cholesterol lowering drugs.
[参考文献]: E Abushanab, Et Al. 1',2'-Seco-Dideoxynucleosides As Potential Anti-Hiv Agents. J Med Chem. 1989 Jan;32(1):76-9.
合成参考文献
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