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参考文献:Synthesis And Photophysics Of Benzazole Based Triazoles With Amino Acid-Derived Pendant Units. Multiparametric Optical Sensors For Bsa And Ct-Dna In Solution
标题:Synthesis And Photophysics Of Benzazole Based Triazoles With Amino Acid-Derived Pendant Units. Multiparametric Optical Sensors For Bsa And Ct-Dna In Solution
摘要:Herein We Report The Synthesis Of A Series Of Amino Acid-Derived Triazoles By An Organocatalytic Cycloaddition Reaction Between Azides And Carbonyl Compounds,Catalyzed By A Simple Amine.These Compounds Present Absorption Maxima Located In The Uv-B Ascribed To Fully Spin And Symmetry Allowed Electronic Transitions And A Main Fluorescence Emission In The Uv-A (Similar To 380 Nm) With A Relatively Large Stokes Shift (5700 Cm(-1)). No Significant Solvatochromism Was Observed In Both Ground And Excited States. Unexpectedly,The Benzoxazole Derivatives Presented Much Higher Fluorescence Quantum Yield Values (40-80%) Of Compared To The Sulfur Analogues (3-6%). In Addition,The Dna Binding Assays Indicated That These Compounds Presented Strong Interaction With Ct-Dna,Which Could Be Attributed To Pi-Stacking And Intermolecular Hydrogen-Bonding. The Interaction Of The Benzazoles With Bovine Serum Albumin (Bsa) Was Also Investigated,Where A Suppression Mechanism Was Observed. In Each Case,Docking Was Performed To Better Understand The Observed Interactions. (C) 2020 Elsevier B.V. All Rights Reserved.
Doi:10.1016/j.Molliq.2020.113092