CAS: 13636-18-5; Fendiline Hcl

专利信息

专利号:US-7853408-B2
优先权日:2005-08-17
标 题 :Method for the design of oligonucleotides for molecular biology techniques
发明人：MAASS SEPULVEDA ALEJANDRO EDUARDO; ARAVENA DUARTE ANDRES OCTAVIO; GONZALEZ CANALES MAURICIO ALEJANDRO; MARTINEZ AGUILERA SERVET; PARADA VALDECANTOS PILAR ANGELICA; EHRENFELD STOLZENBACH KATIA NICOLE
权利人:BIOSIGMA SA
摘要:A method of designing oligonucleotides useful in molecular biology techniques as PCR primers or in other techniques as identification and/or quantification probes is disclosed. The method permits designing specific oligonucleotides for the identification of a determined sequence in a metagenomic sample. The method includes selecting or constructing a database of reference sequences, selecting a subset of sequences belonging to target organisms, selecting candidate oligonucleotides from such sequences, depurating these candidate oligonucleotides according to hybridization specificity and thermodynamic stability criteria, obtaining a list of designed oligonucleotides that fulfill the hybridization specificity and thermodynamic stability criteria, producing materially by chemical synthesis the designed oligonucleotides, and selecting the oligonucleotides which comply with the requirements of the desired process.

专利号:EP-1058679-A4
优先权日:1998-02-25
标题 :SYNTHESIS OF EPOTHILONES, THEIR INTERMEDIATES AND THEIR ANALOGS

专利号:WO-9943653-A1
优先权日:1998-02-25
标 题:Synthesis of epothilones, intermediates thereto and analogues therof

专利号:NZ-506742-A
优先权日:1998-02-25
标题 :Synthesis of desoxyepothilones and hydroxy acid derivative intermediates

专利号:AU-758526-B2
优先权日:1998-02-25
标 题:Synthesis of epothilones, intermediates thereto and analogues therof

专利号:CA-2164671-C
优先权日:1994-12-14
标 题 :Synthesis of mesoporous catalytic materials