CAS: 1207283-85-9; (4S,4As,5Ar,12As)-4-(Dimethylamino)-7-Fluoro-3,10,12,12A-Tetrahydroxy-1,11-Dioxo-9-(2-(Pyrrolidin-1-yl)Acetamido)-1,4,4A,5,5A,6,11,12A-Octahydrotetracene-2-Carboxamide

📜(4S,4As,5Ar,12As)-9-Amino-4-(Dimethylamino)-7-Fluoro-1,4,4A,5,5A,6,11,12A-octahydro-3,10,12,12A-Tetrahydroxy-1,11-Dioxo-2-Naphthacenecarboxamide Dihydrochloride,2-(Pyrrolidin-1-yl)Acetyl Chloride置于2-(Pyrrolidin-1-yl)Acetyl Chloride体系中,用88.7的收率获得依拉环素
参考文献:Org. Process Res. Dev. 2013,17,838-845
标题:Org. Process Res. Dev. 2013,17,838-845

专利信息

专利号:US-10065924-B2
优先权日:2014-07-22
标 题 :Preparation and biological evaluation of viridicatumtoxin analogs
发明人：NICOLAOU KYRIACOS C; HALE CHRISTOPHER R H; NILEWSKI CHRISTIAN; IOANNIDOU HERAKLIDIA; EL MARROUNI ABDELLATIF
权利人:UNIV RICE WILLIAM M
摘要:In one aspect, the present invention provides novel derivatives of viridicatumtoxin of the formula wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.

专利号:PT-117254-B
优先权日:2021-05-26
标题 :METHOD FOR SYNTHESIS OF 9-AMINOMETHYL TETRACYCLINE COMPOUNDS

专利号:US-11980627-B2
优先权日:2019-06-14
标 题 :Triple pharmaceutical composition for proteinaceous infection
发明人：ATIBA JOSHUA O
权利人:ATIBA JOSHUA O
摘要:There are disclosed therapies and preventions of prion protein complex infections. The transcription of the amyloid precursor protein gene and PrP gene and the RNA transcript are the rate-limiting steps and are most susceptible for blockage and control of the process of amyloid protein formation and PrP sc formation. Thus, therapies and prevention regimes for prion protein complex infections interrupt this process at the level of DNA transcription to RNA, RNA transport to the mitochondrion for protein synthesis and deposition in the cerebral cortex neurons.

专利号:US-12291515-B2
优先权日:2021-12-22
标 题 :Pyrrolidine derivative and use thereof
发明人：WANG ZHEMING; TAN HAO
权利人:WANG ZHEMING; RUSHI BIOTECH HANGZHOU CO LTD
摘要:The present invention discloses a pyrrolidine derivative or its optically active isomer, or a pharmaceutically acceptable salt thereof, which is useful as an NAMPT inhibitor, and useful as a potential agent for the chemotherapy of a variety of diseases associated with abnormal NAD+ expression. The pyrrolidine derivative has pyrrolidine as a parent structure, to which pyridinylurea (or substituted pyridinylurea) is attached by an intermediate aliphatic chain, and a side arylformyl (or heterocyclylformyl) group is attached. This structure is an optimized structure of the NAMPT inhibitor FK866, in which the acrylamido group is replaced by a urea structure, to increases the water solubility of the compound. Moreover, the difficulty in synthesis is reduced accordingly, which is conducive to the subsequent industrial production.

专利号:US-10501454-B2
优先权日:2016-07-21
标 题 :Monocyclic β-lactam-siderophore conjugate, and preparation method and use thereof
发明人：YANG YUSHE; TAN LIANG; KOU QUNHUAN
权利人:YANG YUSHE; TAN LIANG; KOU QUNHUAN; SHANGHAI INST MATERIA MEDICA CAS
摘要:The present disclosure relates to the field of pharmaceutical synthesis, and more particularly, relates to a monocyclic β-lactam-siderophore conjugate as well as a method for synthesizing same and its use in the treatment of bacterial infectious diseases. Provided are a monocyclic β-lactam-siderophore conjugate represented by formula (I) as described herein, an optical isomer thereof or a pharmaceutically acceptable salt thereof, and a method for synthesizing same, and a use thereof in treating bacterial infectious diseases.