CAS: 114438-33-4; N-Hydroxy Sulfamethoxazole
该化合物是硫化苯氧新诺明的衍生物,以一个氢氧基为主,它能提高稳定性和对一系列病原体的功效.氢氧基组增加了溶性,减少了肾晶体的可能性,使之适合各种应用.其精确的行动机制针对细菌酶,为药物配方提供了有效的治疗选择.
- 英文名称N-Hydroxy Sulfamethoxazole
- 中文名称N-羟基磺胺甲恶唑
- IUPAC名称4-(hydroxyamino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide
- 其它别名Sulphamethoxazole Hydroxylamine; Hydroxylamine Of Sulfamethoxazole [3-(4-Hydroxylamino Phenylsulfonamido)-5-Methylisoxazole]; 4-(Hydroxyamino)-N-(5-Methyl-1,2-Oxazol-3-yl)Benzenesulfonamide
- CAS编号114438-33-4
- MFCD编号:MFCD00870463
- EINECS号:808-369-7
- FDA UNII编号:S4YF7G89MZ
- 分子式:C10H11N3O4S分子量:269.28
- 产品CID: 177952
- 产品分类有机原料→分子砌块→芳杂环类化合物→异噁唑类化合物
相似化合物
29699-89-6 21312-10-7 723-46-6物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
N-(5-methyl-isoxazol-3-yl)-4-nitro-benzenesulfonamide 4-Nitrobenzenesulfonyl chloridenitroso derivative of sulfamethoxazole sulfamethoxazole合成工艺路线路线简述
📜对硝基苯磺酰氯置于palladium On Activated Charcoal Sodium Hypophosphite体系中,用 四氢呋喃,吡啶,水 用作溶剂,化学反应 24.0H,反应生成磺胺甲恶唑羟胺
参考文献:Synthesis And Reactions Of Nitroso Sulphamethoxazole With Biological Nucleophiles: Implications For Immune Mediated Toxicity
标题:Synthesis And Reactions Of Nitroso Sulphamethoxazole With Biological Nucleophiles: Implications For Immune Mediated Toxicity
摘要:Sulphamethoxazole Hydroxylamine (Smx-Nhoh) And Nitroso Sulphamethoxazole (Smx-No) Were Prepared By A Modified Literature Procedure. Smx-No Produced A Complex Set Of Unstable Intermediates With Sulphur Nucleophiles,But Did Not React With Amino Containing Compounds. No Reactions Were Observed Between Sulphamethoxazole (Smx)/smx-Nhoh And The Nucleophiles Used In This Study. Thus Antigens Formed From N-Oxidation Of Smx Are Likely To Be Unstable In Vivo. Copyright (C) 1996 Elsevier Science Ltd
Doi:10.1016/s0960-894X(96)00260-0
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
摘要:S113 | SWISSPHARMA24 | 2024 Swiss Pharmaceutical List with Metabolites | DOI:10.5281/zenodo.10501043
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