专利号:US-8242310-B2 优先权日:2008-09-10 标题:Processes for the preparation of aminosulfone compounds 发明人:SAINDANE MANOHAR T; GE CHUANSHENG 权利人:SAINDANE MANOHAR T; GE CHUANSHENG; CELGENE CORP 摘要:Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of isoindoline based PDE 4 modulators.
专利号:US-9688623-B2 优先权日:2012-02-21 标题:Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine 发明人:VENKATESWARALU JASTI; RAJENDIRAN CHINNAPILLAI; REDDY NALLAMADDI RAVIKUMAR; CONNOLLY TERRENCE JOSEPH; RUCHELMAN ALEXANDER L; ECKERT JEFFREY; FRANK ANTHONY JOSEPH 权利人:CELGENE CORP 摘要:Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-α. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.
专利号:US-6187923-B1 优先权日:1998-11-09 标题 :Process for the synthesis of quinazolinones 发明人:DENER JEFFREY MARK; LY CUONG QUOC 权利人:AXYS ADVANCED TECHNOLOGIES INC 摘要:The present invention provides a process for synthesizing a compound or a library of compounds of Formula 1A and 1B:
专利号:WO-0053313-A2 优先权日:1999-03-09 标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries
专利号:WO-2016202806-A1 优先权日:2015-06-15 标题:A novel synthetic pathway towards apremilast 发明人:STAVBER GAJ 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to a process for providing a chiral β-hydroxysulfone compound, an intermediate useful in the synthesis of the isoindoline-based compound apremilast.
专利号:CN-104744323-A 优先权日:2015-03-11 标题 :Synthesis process of apremilast chiral amine intermediate
参考标题:Design And Synthesis Of A Library Of Tertiary Amides: Evaluation As Mimetics Of The Melanocortins' Active Core 作者:Felikss Mutulis,Jana Kreicberga,Sviatlana Yahorava,Ilze Mutule,Larisa Borisova-Jan,Aleh Yahorau,Ruta Muceniece,Sandra Azena,Santa Veiksina,Ramona Petrovska |发布日期:2007.9.1 摘要:Acceptable Results. According To This Approach An Efficient Formation Of Schiff Bases Was Achieved In The Presence Of Ticl(4). Substances Were Isolated By Reversed Phase Chromatography; In Some Cases Isomers Were Additionally Separated By Chiral Chromatography On Chirobiotic T. When Tested On Human Recombinant Melanocortin Receptors All The Tertiary Amides Showed Some Binding Affinities; For The Highest Affinity