CAS: 932-66-1; 1-(Cyclohex-1-En-1-yl)Ethanone

该化合物是一种含有分子式C8H12O的环球化合物,其分子式为C8H12O,其成分包括一个氯酮和一个烷功能组,这种结构使它成为有机合成的多用途中间体,特别是在Michael添加物,Diels-Alder反应和其他循环过程中,它的活性允许有选择地进行修改,从而能够生产复杂的循环框架.该化合物通常用于制药和精细化学研究,因为它能够作为生物活性分子的先质.在标准条件下,它表现出良好的稳定性,便于处理和储存.它的合成效用和结构特点使得它对于医药化学和材料科学的应用具有价值.

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1192-88-7 1193-18-6 18031-40-8

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CAS号931-49-7 1-乙炔基-1-环己烯 | CAS号76888-38-5 (rac)-1-(cycloh... | CAS号78-27-3 乙炔基环己醇 | CAS号823-76-7 乙酰基环己烷 | CAS号114140-77-1 8-bromo°Ct-3-en... | CAS号75-36-5 乙酰氯 | CAS号110-83-8 环己烯 | CAS号29773-63-5 1-p-tosyloxy-3-... | CAS号1721-93-3 1-甲基异喹啉 | CAS号823-76-7 乙酰基环己烷 | CAS号79605-68-8 (rac)-1-(cycloh... | CAS号78174-24-0 ethyl ((1S,2R)-... | CAS号78174-22-8 4-(1'-methyl-1'... | CAS号51-79-6 氨基甲酸乙酯 | CAS号25910-97-8 1-Cyclohexene-1... | CAS号52600-91-6 3-乙氧基苯乙酮 | CAS号134521-56-5 1-Acetyl-3-etho...

合成工艺路线路线简述

  • 78-27-3 = 932-66-1
    反应条件:1.1 Catalysts: Glycerol,Iron Chloride (Fecl3); 10 Min,Rt
    标题:Deep Eutectic Solvent-Catalyzed Meyer-Schuster Rearrangement Of Propargylic Alcohols Under Mild And Bench Reaction Conditions
    作者:Rios-Lombardia,Nicolas; Cicco,Luciana; Yamamoto,Kota; Hernandez-Fernandez,Jose A.; Moris,Francisco; Et Al
    参考文献:Chemical Communications (Cambridge 日期:2020 卷标:56(96) 页码:15165-15168]

    931-49-7 = 932-66-1
    反应条件:1.1 Catalysts: 1,4-Benzenedimethanol,Polymer With Naphthalene (Sulfonated) Solvents: Water; 8 H,120 °C
    标题:Hydration Of Aromatic Terminal Alkynes Catalyzed By Sulfonated Condensed Polynuclear Aromatic (S-Copna) Resin In Water
    作者:Tanemura,Kiyoshi; Suzuki,Tsuneo
    参考文献:Tetrahedron Letters 日期:2017 卷标:58(10) 页码:955-958]

    931-49-7 = 932-66-1
    反应条件:1.1 Catalysts: Silver Triflate,[bis(1,1-Dimethylethyl)[5-Methoxy-3,4,6-Trimethyl-2′,4′,6′-Tris(1-Methylethyl)[1... Solvents: Methanol,Water; 20 H,80 °C
    标题:Ligand Effects In The Gold Catalyzed Hydration Of Alkynes
    作者:Ebule,Rene E.; Malhotra,Deepika; Hammond,Gerald B.; Xu,Bo
    参考文献:Advanced Synthesis & Catalysis 日期:2016 卷标:358(9) 页码:1478-1481]

    931-49-7 = 932-66-1
    反应条件:1.1 Reagents: Water Catalysts: Methanesulfonic Acid,1,1,1-Trifluoro-,Gallium Salt (3:1) Solvents: Acetic Acid; 2 H,100 °C
    标题:Efficient Hydration Of Alkynes Through Acid-Assisted Bronsted Acid Catalysis
    作者:Liang,Shengzong; Hammond,Gerald B.; Xu,Bo
    参考文献:Chemical Communications (Cambridge 日期:2015 卷标:51(5) 页码:903-906]

    931-49-7 = 932-66-1
    反应条件:1.1 Reagents: Water Catalysts: Tin Tungsten Oxide Solvents: Toluene; 1 H,100 °C
    标题:Heterogeneously Catalyzed Efficient Hydration Of Alkynes To Ketones By Tin-Tungsten Mixed Oxides
    作者:Jin,Xiongjie; Oishi,Takamichi; Yamaguchi,Kazuya; Mizuno,Noritaka
    参考文献:Chemistry - A European Journal 日期:2011 卷标:17(4) 页码:1261-1267]

    931-49-7 = 932-66-1
    反应条件:1.1 Reagents: Formic Acid
    标题:Hydration Of Alkynes In Anhydrous Medium With Formic Acid As Water Donor
    作者:Menashe,Naim; Shvo,Youval
    参考文献:Journal Of Organic Chemistry 日期:1993 卷标:58(26) 页码:7434-9]

    78-27-3 = 932-66-1
    反应条件:1.1 Reagents: Acetic Acid,Dowex 50W Solvents: Water
    标题:Phenol-Catalyzed Claisen Orthoester Rearrangement Of Allylic Alcohols With Trimethyl β-(Methoxy)Orthopropionate
    作者:Iqbal,Fazila; Ateeq,Humayun S.; Malik,Abdul; Ali,Zeeshan; Ali,Zulfiqar
    参考文献:Zeitschrift Fuer Naturforschung 日期:1998 卷标:53(10) 页码:1244-1245]

    91890-17-4 = 932-66-1
    反应条件:1.1 Reagents: Hydrochloric Acid,Water Solvents: Diethyl Ether
    标题:Synthetic Uses Of Tosylmethyl Isocyanide (Tosmic)
    作者:Van Leusen,Daan; Van Leusen,Albert M.
    参考文献:Organic Reactions (Hoboken 日期:2001 卷标:57]

    931-49-7 = 932-66-1
    反应条件:1.1 Catalysts: Aurate(2-),[1,3-Bis[2,6-Bis(1-Methylethyl)-4-Sulfophenyl]-1,3-Dihydro-2H-Imidaz... Solvents: Methanol,Water; 2 H,100 °C
    标题:A Structure/catalytic Activity Study Of Gold(I)-Nhc Complexes,As Well As Their Recyclability And Reusability,In The Hydration Of Alkynes In Aqueous Medium
    作者:Fernandez,Gabriela A.; Chopa,Alicia B.; Silbestri,Gustavo F.
    参考文献:Catalysis Science & Technology 日期:2016 卷标:6(6) 页码:1921-1929]

    29372-98-3 = 932-66-1
    反应条件:1.1 Reagents: Alumina
    标题:Aluminum Oxide Catalyzed Isomerization Of Acylated Cycloalkenes
    作者:Hudlicky,T.; Srnak,T.
    参考文献:Tetrahedron Letters 日期:1981 卷标:22(35) 页码:3351-4]

    1728-25-2 = 932-66-1
    反应条件:1.1 Reagents: Triethylamine Solvents: Ethanol,Water
    标题:Rearrangement Of 2-Cycloalken-1-Ones To 1-Cycloalkenyl Methyl Ketones
    作者:Helwig,Reinhard; Hanack,Michael
    参考文献:Justus Liebigs Annalen Der Chemie 日期:1977 卷标:(4) 页码:614-23]

    931-49-7 = 932-66-1
    反应条件:1.1 Catalysts: Chloro[(Isocyano-Kc)Cyclohexane]Gold,Potassium Tetrakis(Pentafluorophenyl)Borate Solvents: Methanol,Water; 24 H,Rt
    标题:Hydration Of Alkynes At Room Temperature Catalyzed By Gold(I) Isocyanide Compounds
    作者:Xu,Yun; Hu,Xingbang; Shao,Jing; Yang,Guoqiang; Wu,Youting; Et Al
    参考文献:Green Chemistry 日期:2015 卷标:17(1) 页码:532-537]

    78-27-3 = 932-66-1
    反应条件:1.1 Catalysts: Rhenium(1+),Tricarbonyl[o,O-Diphenyl N-[[(Diphenylphosphino-Kp)Methyl]Diphenylp... Solvents: 1-Butyl-3-Methylimidazolium Hexafluorophosphate; 1.5 H,130 °C
    标题:Novel Rhenium(I) Catalysts For The Isomerization Of Propargylic Alcohols Into α,β-Unsaturated Carbonyl Compounds: An Unprecedented Recyclable Catalytic System In Ionic Liquids
    作者:Garcia-Alvarez,Joaquin; Diez,Josefina; Gimeno,Jose; Seifried,Christine M.
    参考文献:Chemical Communications (Cambridge 日期:2011 卷标:47(22) 页码:6470-6472]

    931-49-7 = 932-66-1
    反应条件:1.1 Catalysts: [1,1,1-Trifluoro-N-[(Trifluoromethyl)Sulfonyl-Ko]Methanesulfonamidato-Ko]Silver,[[2′-[bis(Tricyclo[3.3.1.13,7]Dec-1-Yl)Phosphino-Kp][1,1′-Biphenyl]-3-Yl]-1-Pyrr... Solvents: Methanol,Water; 8 H,25 °C
    标题:Au(I) Complexes As The Efficient Catalyst For Hydration Of Alkynes At Room Temperature
    作者:Wu,Gongde; Wang,Xiaoli; Zhang,Liming; Jiang,Taineng
    参考文献:Gaodeng Xuexiao Huaxue Xuebao 日期:2015 卷标:36(12) 页码:2461-2467]

    78-27-3 = 932-66-1
    反应条件:1.1 Catalysts: Carbon Monoxide,Platinum Tetrachloride Solvents: 1,2-Dichloroethane,Water
    标题:Hydration Of Alkynes By A Ptcl4-Co Catalyst
    作者:Baidossi,Waeel; Lahav,Michal; Blum,Jochanan
    参考文献:Journal Of Organic Chemistry 日期:1997 卷标:62(3) 页码:669-672]

    931-49-7 = 932-66-1
    反应条件:1.1 Reagents: Water Catalysts: Sulfuric Acid,(Sp-5-14)-[1,2,3,7,8,12,13,17,18,19-Decadehydro-21,22-Dihydro-5,10,15-Tris(2,3,4... Solvents: Methanol; 12 H,80 °C
    标题:Hydration Of Terminal Alkynes Catalyzed By Cobalt Corrole Complex
    作者:Lai,Jia-Wei; Liu,Zhao-Yang; Chen,Xiao-Yan; Zhang,Hao; Liu,Hai-Yang
    参考文献:Tetrahedron Letters 日期:2020 卷标:61(43)]

    931-49-7 = 932-66-1
    反应条件:1.1 Solvents: Trifluoroacetic Acid,Water; 2.5 H,Rt
    标题:Tfa-Mediated Alkyne Hydration Reaction To Synthesize Methyl Ketones
    作者:Chen,Z. W.; Luo,M. T.; Ye,D. N.
    参考文献:Asian Journal Of Chemistry 日期:2014 卷标:26(19) 页码:6528-6530]

    143771-14-6 = 932-66-1
    反应条件:1.1 Reagents: Trimethylsilyl Iodide Solvents: Chloroform; 5 H,Rt1.2 Solvents: Methanol; 0.5 H,Rt
    标题:An Investigation Of The Behavior Of α,β-Unsaturated Sulfoxides In The Presence Of Trimethylsilyl Iodide
    作者:Aversa,Maria C.; Barattucci,Anna; Bonaccorsi,Paola; Giannetto,Placido
    参考文献:Tetrahedron 日期:2002 卷标:58(51) 页码:10145-10150]

    78-27-3 = 932-66-1
    反应条件:1.1 Reagents: Dowex 50W Solvents: Acetic Acid,Water
    标题:Facile Approach To Versatile Chiral Intermediates For Fused Cyclopentanoid Natural Products
    作者:Zulfiquar,Fazila; Malik,Abdul
    参考文献:Zeitschrift Fuer Naturforschung 日期:2001 卷标:56(11) 页码:1227-1234]

    78-27-3 = 932-66-1
    反应条件:1.1 Catalysts: Trifluoromethanesulfonic Acid Solvents: Nitromethane; 2 H,50 °C1.2 Catalysts: 1H-Imidazolium,1-Methyl-3-[3-[[[(1,1,2,2,3,3,4,4,4-Nonafluorobutyl)Sulfonyl]Ami... Solvents: Toluene; 1 H,50 °C
    标题:"Release And Catch" Effect Of Perfluoroalkylsulfonylimide-Functionalized Imidazole/pyridine On Bronsted Acids In Organic Systems
    作者:Ma,Zhong-Hua; You,Li; Ren,Xiao-Fei; Wang,Yun; Gu,Yanlong; Et Al
    参考文献:Chemcatchem 日期:2016 卷标:8(21) 页码:3394-3401
📜2-乙酰基环己酮置于四(三苯基膦)钯 三乙胺,Lithium Bromide体系中,用 四氢呋喃,乙二醇二甲醚 作为反应溶剂,化学反应 48.0H,反应生成 乙酰基环已烯
参考文献:Palladium-Catalyzed Cross-Coupling Of .Beta.-(Methanesulfonyl)Oxyenones With Organostannanes
标题:Palladium-Catalyzed Cross-Coupling Of .Beta.-(Methanesulfonyl)Oxyenones With Organostannanes
摘要:Beta-(Methanesulfonyl)Oxy Enones,Derived From 1,3-Diones,Cross-Couple With Vinylstannanes In 50-80% Yields When A Substoichiometric Amount Of Pd(Pph3)4 And Stoichiometric Lithium Bromide Are Used. Phenyltributylstannane Affords Low Yields Of Cross-Coupled Product. Tetrabutyltin,Tributyltin Hydride,And Ethynyltributyltin Do Not Couple Under The Reaction Conditions. The Reaction Is Proposed To Involve In Situ Formation Of The Beta-Bromo Enone,Oxidative Addition To The Pd(0) Catalyst,Transmetalation,And Reductive Elimination To Afford Cross-Coupled Products. The Analogous Enol Phosphates Undergo Coupling In Low Yields,The Major Product Resulting From Regeneration Of The 1,3-Dione.
DOI:10.1021/jo00004A028

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主要参考文献

参考标题:Fe(0)-Mediated Synthesis Of Tri- And Tetra-Substituted Olefins From Carbonyls: An Environmentally Friendly Alternative To Cr(II)
作者:J. R. Falck,Romain Bejot,Deb K. Barma,Anish Bandyopadhyay,Suju Joseph,Charles Mioskowski |发布日期:2006.10.1
摘要:Carbonyls By Activated Polyhalides. In Many Instances, Fe(0) Was Equivalent Or Superior To Cr(II). Notably, Fe(0), But Not Cr(II), Proved Compatible With A Wide Range Of Functionality, Inter Alia, Unprotected Phenol, Aryl Nitro, Carboxylic Acid, And Alkyl Nitrile. A Surprising Reversal Of Stereoselectivity For Aldehydes Versus Ketones Was Observed Using Both Metals. The Resultant α-Halo-α,β-Unsaturated Or α

合成参考文献

参考DOI号:10.1016/0040-4020(96)00382-1
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