CAS: 63088-04-0; (±)-Threo-3-Methylglutamic Acid

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31137-74-3 6893-26-1 56-86-0

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(2S,3R)-2-Dibenzylamino-3-methyl-pentanedioic acid (2R,3S)-2-Dibenzylamino-3-methyl-pentanedioic acid di-tert-butyl ester cis-3-methylpyroglutamic acid 2,2-diethyl 3-methyl-5-oxopyrrolidine-2,2-dicarboxylate (2S,3R)-2-amino-3-methylpentanedioic acid (2R,3S)-3-methylglutamic acid N-(p-toluenesulfonyl)-threo-β-methylglutamic acid

合成工艺路线路线简述

    📜(2R,3S)-2-(Dibenzylamino)-3-Methylpentanedioic Acid 以65%的收率获得产物
    参考文献:Yamaguchi,Masahiko;Torisu,Kazuhiko;Minami,Toru,Chem. Lett.,(1990) N,C. 377-380
    标题:Yamaguchi,Masahiko;Torisu,Kazuhiko;Minami,Toru,Chem. Lett.,(1990) N,C. 377-380

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    主要参考文献

    [参考文献]: Eliasof S, Et Al. Pharmacological Characterization Of Threo-3-Methylglutamic Acid With Excitatory Amino Acid Transporters In Native And Recombinant Systems. J Neurochem. 2001 Apr;77(2):550-7.
    [参考文献]: Pignataro L, Et Al. Nonsynaptic Localization Of The Excitatory Amino Acid Transporter 4 In Photoreceptors. Mol Cell Neurosci. 2005 Mar;28(3):440-51.

    合成参考文献


    参考文献:10.1073/pnas.2005463117
    摘要:Abrams RPM, Yasgar A, Teramoto T, Lee MH, Dorjsuren D, Eastman RT, Malik N, Zakharov AV, Li W, Bachani M, Brimacombe K, Steiner JP, Hall MD, Balasubramanian A, Jadhav A, Padmanabhan R, Simeonov A, Nath A. Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proc Natl Acad Sci U S A. 2020 Dec 08;117(49):31365–75.
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