CAS: 6294-89-9; Methyl Hydrazinecarboxylate

相似化合物

21075-83-2 5331-43-1 870-46-2

上下游产品

CAS号616-38-6 碳酸二甲酯 | CAS号14442-53-6 methyl N-nitr°C... | CAS号79-22-1 氯甲酸甲酯 | CAS号76529-39-0 methyl (phenyls... | CAS号64-19-7 冰醋酸 | CAS号106868-88-6 3-(4-脲氨基)丙基三乙氧基硅烷 | CAS号104484-87-9 methyl N-[(2-ph... | CAS号17643-54-8 甲基伸腈基羧酸盐 | CAS号497-18-7 碳酰肼 | CAS号5097-86-9 4-(4-氯苯基)-1H-1,... | CAS号21520-79-6 N-羟基肼甲酰胺 | CAS号80240-40-0 4-(4-氟苯基)-1H-1,... | CAS号107-31-3 甲酸甲酯 | CAS号614-27-7 苯甲酰乙酸甲酯 | CAS号7497-61-2 methyl (3R)-3-h...

碳酸二甲酯置于一水合肼体系中,化学反应 24.5H,以94%的收率获得产物肼基甲酸甲酯
参考文献:含1,2,3-噻二唑的(e)-β-法尼烯类似物的合成及生物学活性
标题:含1,2,3-噻二唑的(e)-β-法尼烯类似物的合成及生物学活性
摘要:摘要为了发现对蚜虫具有高活性的新型化合物,设计合成了一系列含有1,2,3-噻二唑的新型(e)-β-法呢烯类似物,并通过ir,1 H确定了结构. NMR,13 C NMR和hrms(esi).通过HPLC和1 H NMR技术研究了代表性化合物的稳定性.驱避活性结果表明,化合物8H和8J分别显示出60.3%和62.0%的驱避率.杀蚜生物测定结果表明,大多数类似物对桃蚜(myzus Persicae)表现出相当的杀蚜活性.尤其是类似物8L,8S和8T表现出高活性,Lc 50值分别为33.4μg/ Ml,50.2μg/ Ml和61.8μg/ Ml,高于先导化合物(e)-β-法呢烯,
DOI:10.1016/j.Cclet.2016.10.030

专利信息

专利号:US-2008125587-A1
优先权日:2006-05-25
标 题 :Synthesis of triazole compounds that modulate HSP90 activity
发明人：CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
权利人:CHIMMANAMADA DINESH U; LEE CHI-WAN; JAMES DAVID; ZHANG SHIJIE; YING WEIWEN; CHAE JUNGHYUN; PRZEWLOKA TERESA
摘要:The present invention provides novel methods of preparing triazole compounds which inhibit the activity of Hsp90. One embodiment of the invention is directed to methods for preparing a triazole compound represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising the steps of: a) reacting an amide represented by the following Structural Formula: n n n n n n n n n n with a thionation reagent to form a thioamide; b) reacting the thioamide of step a) with hydrazine to form a hydrazonamide; c) reacting the hydrazonamide of step b) with a carbonylation or a thiocarbonylation reagent. n In one embodiment, the present invention is a method of synthesis of a compound of formula (IA) n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof, comprising reacting a compound of formula (IIA) n n n n n n n n n n with an oxidizing agent, thereby producing a compound of formula (IA). n The present invention is also directed to a method of preparing a compound or a tautomer thereof represented by the following Structural Formula: n n n n n n n n n n or a tautomer, a pharmaceutically acceptable salt, solvate, or clathrate, or a prodrug thereof. The method comprises the step of reacting a first starting compound represented by the following Structural Formula: n n n n n n n n n n in the presence of a mercuric salt, with a second starting compound represented by the following Structural Formula:

专利号:US-7786156-B2
优先权日:2004-01-28
标 题 :Synthesis methods and intermediates for the manufacture of Rizatriptan
发明人：MARTIN PIERRE; BERENS ULRICH; BOUDIER ANDREAS; DOSENBACH OLIVER
权利人:RATIOPHARM GMBH
摘要:The invention relates to a process for the manufacture of an 1,2,4-triazol-1-yl compound of the formula [A], n nor a salt thereof, wherein each of R3 and R4 is hydrogen or lower alkyl, said process comprising reacting a hydrazine compound of the formula [B]n n nwherein R is hydrogen or acyl, R2 is hydrogen or a protecting group, are hydrogen or lower alkyl, and R6 is hydrogen or COOR7, or a salt thereof, with a 1,2,4-triazolyl forming reagent.n n In addition, novel intermediates for the synthesis of the anti-migraine agent Rizatriptan and methods for their synthesis are presented.

专利号:US-7250435-B2
优先权日:1999-10-20
标 题:Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP P; YUE EDDY
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n nthat are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G.n n This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:CN-120041848-A
优先权日:2025-02-18
标 题 :Method for electrochemically synthesizing chiral beta-ester nitrile and application of chiral beta-ester nitrile in synthesis of baclofen and rolipram

专利号:US-4803280-A
优先权日:1986-07-08
标题:Substituted 1,2,3-thia-diazole-4-thiolates
发明人：LEE VING J; CURRAN WILLIAM V
权利人:AMERICAN CYANAMID CO
摘要:Intermediates useful for synthesis of cephalosporins are disclosed, which intermediates are concerned with 1,2,3-thiadiazole-4-thiolates and the preparation of such thiolates.

专利号:FR-2628428-A1
优先权日:1988-03-09
标题:PROCESS FOR THE PREPARATION OF TRANSITION METAL COMPLEXES USEFUL AS RADIOPHARMACEUTICAL PRODUCTS OR FOR THE SYNTHESIS OF NEW RADIOPHARMACEUTICAL PRODUCTS