CAS: 619-21-6; 3-Formylbenzoic Acid

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CAS号626-19-7 间苯二甲醛 | CAS号124-38-9 二氧化碳 | CAS号67073-72-7 3-溴苯甲醛二甲基乙缩醛 | CAS号110-89-4 六氢吡啶 | CAS号28286-79-5 3-羟甲基苯甲酸 | CAS号36747-51-0 3-(二氯甲基)苯甲酰氯 | CAS号6515-58-8 3-溴甲基苯甲酸 | CAS号64407-07-4 间氰基氯苄 | CAS号620-22-4 间甲基苯腈 | CAS号33745-47-0 3-甲酰基苯甲酸乙酯 | CAS号247186-56-7 3-甲酰基苯甲酸叔丁酯 | CAS号252928-82-8 3-(1,3-噁唑-5-基)苯甲酸 | CAS号52178-50-4 3-甲醛苯甲酸甲酯 | CAS号115974-98-6 3-(2-carboxyeth... | CAS号75650-38-3 Benzoyl chlorid... | CAS号88486-13-9 3-[cyano-(3,4-d... | CAS号91047-79-9 (E)-3-(3-ethoxy... | CAS号920536-20-5 3-formyl-N-[[4-... | CAS号61471-38-3 3-[(phenylhydra...

间甲基苯腈置于乌洛托品,水,氯,Sodium Hydroxide体系中,用 四氯化碳,氯仿 作为反应溶剂,化学反应 22.0H,反应生成 3-羧基苯甲醛
参考文献:一种3-羧基苯甲醛的制备方法
标题:一种3-羧基苯甲醛的制备方法
摘要:本发明公开一种3‑羧基苯甲醛的制备方法,包括以下步骤:以间甲基苯腈为起始原料,进行第一水解反应,然后加酸进行酸化反应,得到间甲基苯甲酸;将间甲基苯甲酸进行氯代反应,得到3‑羧基苄基氯;将3‑羧基苄基氯和乌洛托品混合,进行氧化反应,然后加冰醋酸和水进行第二水解反应,得到3‑羧基苯甲醛.本发明方法以成本低廉的间甲基苯腈为原料,经水解,氯代,氧化和水解一系列过程合成3‑羧基苯甲醛,产物纯度和收率均较高;本发明方法工艺操作简单,安全,所用原料易于得到,且成本低,适合于工业生产.

专利信息

专利号:US-6251689-B1
优先权日:1998-05-14
标 题:Methods for the solid phase synthesis of combinatorial libraries of benzimidazoles benzoxazoles benzothiazoles and derivatives thereof
发明人：LABORDE EDGARDO; MATSUMOTO YUKIHARU
权利人:TELIK INC
摘要:The present invention provides an efficient and versatile method for the synthesis and screening of combinatorial libraries of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof. In order to expedite the synthesis of large arrays of compounds possessing these core structures, a general methodology for solid phase synthesis of these derivatives is provided. Arrays of benzimidazoles, benzoxazoles, benzothiazoles, and derivatives thereof useful as peptidomimetics and for the identification of agents having antifungal, antiviral, antimicrobial, anticoagulant, and antiulcer activity, or use in the treatment of inflammation, hypertension, cancer, and other conditions can be prepared by this method.

专利号:US-5861532-A
优先权日:1997-03-04
标 题:Solid-phase synthesis of N-alkyl amides
发明人：BROWN EDWARD G; NUSS JOHN M
权利人:CHIRON CORP
摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.

专利号:US-2009143426-A1
优先权日:2007-12-04
标 题:Synthesis of 1,3,6-trisubstituted-2-carboxyquinol-4-ones as selective ET A antagonists and their use as medicaments
发明人：STEPHANI RALPH ANTHONY; PATEL HARDIK JITENDRA; REZNIK SANDRA EVE; CANTOR JEROME OWEN
权利人:STEPHANI RALPH ANTHONY; PATEL HARDIK JITENDRA; REZNIK SANDRA EVE; CANTOR JEROME OWEN
摘要:The invention discloses the composition and preparation of various 1,3,6-trisubstituted-2-carboxy-quinol-4-ones of the formula 1 where R is H, alkyl, haloalkyl or hydroxyalkyl, R′ is alkyl, nitro, halogen or NR 2 ′″ where R′″ is alkyl or cycloalkyl, and R″ is H or alkyl. The composition of the invented compounds as methods of antagonizing the action of endothelin-1 to treat cardiovascular, pulmonary diseases and obstetric disorders and preterm labor and preeclampsia in mammals is disclosed.

专利号:US-2005176941-A1
优先权日:2002-02-13
标 题:Nucleoside analogues whose sugar moieties are bound in s-form and oligonucleotide derivatives comprising nucleotide analogues thereof
发明人：IMANISHI TAKESHI; OBIKA SATOSHI
摘要:Compounds of the following general formula (1) and salts thereof: n n nwhere A represents an alkylene group having 1 to 2 carbon atoms, etc.; B represents an aromatic heterocyclic group which may have a substituent, etc.; R 1 and R 2 each represent a hydrogen atom, a protective group for a hydroxyl group for synthesis of nucleic acid, a phosphate group, or —P(R 4 )R 5 [where R 4 and R 5 are the same or different, and each represent a hydroxyl group, a hydroxyl group protected with a protective group for synthesis of nucleic acid, a mercapto group, a mercapto group protected with a protective group for synthesis of nucleic acid, etc.]; and R 3 represents a hydrogen atom, a halogen atom, a hydroxyl group, a hydroxyl group protected with a protective group for synthesis of nucleic acid, etc. nThese compounds are useful for producing oligonucleotide analogues useful for the antisense method, antigene method, etc., and for producing their intermediates.

专利号:US-2023295613-A1
优先权日:2020-02-14
标 题:Long chain carbon and cyclic amino acids substrates for genetic code reprogramming
发明人：JEWETT MICHAEL C; LEE JOONGOO; MOORE JEFFREY S; SCHWARZ KEVIN J
权利人:UNIV NORTHWESTERN; UNIV ILLINOIS
摘要:Abstract: Disclosed are methods, systems, components, and compositions for synthesis of sequence defined polymers. The methods, systems, components, and compositions may be utilized for incorporating novel substrates that include non-standard amino acid monomers and non-amino acid monomers into sequence defined polymers. As disclosed herein, the novel substrates may be utilized for acylation of tRNA via flexizyme catalyzed reactions. The tRNAs thus acylated with the novel substrates may be utilized in synthesis platforms for incorporating the novel substrates into a sequence defined polymer.

专利号:US-10189822-B2
优先权日:2015-03-19
标 题:Heterocyclic modulators of lipid synthesis
发明人：OSLOB JOHAN D; MCDOWELL ROBERT S; JOHNSON RUSSELL; YANG HANBIAO; EVANCHIK MARC; ZAHARIA CRISTIANA A; CAI HAIYING; HU LILY W; DUKE GREGORY; OHOL-GUPTA YAMINI; HEUER TIMOTHY SEAN; O'FARRELL MARIE
权利人:3 V BIOSCIENCES INC
摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders.