CAS: 5407-04-5; 3-Chloro-N,N-Dimethylpropan-1-Amine Hydrochloride

该化合物是一种有机化合物,其特征是其矿物质和氯化烷功能组;是一种四硝基铵盐,其典型特性是,由于氯化离子的存在,在水和极有机溶剂中具有湿性,可溶性;该化合物经常用于有机合成,并作为生产药品和农用化学品的一个中间体;其结构包括附属于二甲基氨基化合物组的支气链,有助于其基本性和再活性;盐酸形式表明,它是碱与盐酸反应形成的盐,增强了其稳定性和溶性;安全考虑包括谨慎处理,因为它可能刺激皮肤和眼睛;应保持适当的储存条件以防止降解;

英文名称3-Chloro-N,N-Dimethylpropan-1-Amine Hydrochloride
中文名称N,N-二甲氨基氯丙烷盐酸盐
IUPAC名称3-chloro-N,N-dimethylpropan-1-amine hydrochloride
其它别名(3-Chloropropyl)Dimethylamine Hydrochloride ; (3-Chloro-Propyl)-Dimethylamine Hydrochloride ; (3-Chloro-Propyl)-Dimethyl-Amine Hydrochloride ; (3Chloro-Propyl)-Dimethyl-Amine Hydrochloride ; 1-Chloro-3-(Dimethylamino)Propane Hydrochloride ; 3-Chloro-N',N'
CAS编号5407-04-5
MFCD编号:MFCD00012521
EINECS号:226-467-2
FDA UNII编号:4031FU3Q6G
分子式:C5H13Cl2N
分子量:158.07
产品CID: 2299694
产品分类有机原料→分子砌块→脂肪链类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: LJQNMDZRCXJETK-UHFFFAOYSA-N
InChI=1S/C5H12ClN.ClH/c1-7(2)5-3-4-6;/h3-5H2,1-2H3;1H…
计算化学: 氢键受体数1.0氢键供体数0.0可旋转键数3.0

相似化合物

109-54-6 114326-14-6 365432-21-9

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
皮肤腐蚀/刺激类别2
严重眼刺激类别2
水生慢性毒性类别3
特定目标器官毒性 - 单次接触类别3
致突变性类别2
皮肤腐蚀类别1B
严重眼刺激类别2A
警示词Warning(警告)
危险描述H302 |吞咽有害.
H315 |造成皮肤刺激.
H319 |造成严重眼刺激.
H412 |对水生生物有害并具有长期持续影响.
H335 |可能引起呼吸道刺激.
H341 |怀疑导致遗传缺陷.
H314 |造成严重皮肤灼伤和眼损伤.
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
UN编号NONH for all modes of transport
危险品标志Xn,Xi
风险等级Irritant
安全声明26-61-37/39-36
危险类别码22-36/37/38-52/53
WGK Germany3

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

合成工艺路线路线简述

合成目标产物 3-(Dimethylamino)Propyl Chloride Hydrochloride 主要起始原料 Dimethylamine And Allyl Chloride
(文献来源)合成步骤主要原料 Dimethylamine 和 Allyl Chloride

3-二甲氨基-1-丙醇置于氯化亚砜体系中,用氯仿作为反应溶剂,化学反应生成 N,N-二甲氨基氯丙烷盐酸盐
参考文献:侧链对叔胺官能化多肽的ph和热响应性的影响
标题:侧链对叔胺官能化多肽的ph和热响应性的影响
摘要:侧链上的ph的结构影响的系统调查和叔胺官能化聚(热响应性升-谷氨酸)s(ta-的pgs)中的溶液中进行.通过铜(i)催化的叠氮基叔胺与聚(γ-炔丙基-L-谷氨酸)(pplg)的叠氮化物-炔烃环加成点击反应有效合成了ta-Pgs聚合物.进行了比浊法测量,以表征ta-Pg在水溶液中的ph和温度诱导的相变,这表明该性质对氮的结构依赖性取代基团和1,2,3-三唑环与侧链中叔胺基团之间的"连接基".详细地讲,Ta-Pg的ph响应特性基本上由侧链中n-取代基团的疏水性决定,Ph转变点(ph T)随着n-取代基团疏水性的增加而降低,而ta Pg的温度响应性受n取代基或"连接基"的影响.具有中等n取代胺基(例如dea,Pr和pd)或支链"连接子"(例如iso-丙烯和2-甲基丙烯基)更可能表达因ph值变化而调整的lcst型相变.这项研究揭示的这些结构-属性关系将有助于开发ta-Pg在智能药物输送系统中的应用.©2013
DOI:10.1002/pola.27048

海关参考信息

2903110000-一氯甲烷及氯乙烷
2921199090-其他无环单胺
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-7576234-B2
优先权日:2002-05-15
标题 :Synthesis of 2-alkyl amino acids
发明人：CHORGHADE MUKUND S; GURJAR MUKUND K; MOHAPATRA DEBENDRA K
权利人:GENZYME CORP
摘要:Non-natural amino acids such as 2-alkylated amino acids allow for the synthesis of a wider variety of peptidal and non-peptidal pharmaceutically active agents. A method of preparing a 2-alkyl amino acid involves a Michael-type addition of a nucleophile to a dialkyl 2-methylidenylpropan-1,3-dioate and the conversion of a ester moiety into an amino moiety. The present invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

专利号:US-8399502-B2
优先权日:2008-09-17
标题 :Analogs of indole-3-carbinol and their use as agents against infection
发明人：JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN
权利人:JONG LING; JIANG FAMING; LI GAOQUAN; MORTELMANS KRISTIEN; STANFORD RES INST INT
摘要:Compounds useful as antibacterial agents are provided. The compounds are analogs of indole-3-carbinol and have a backbone selected from dihydroindolo[2,3-b]carbazole, 2,2â€²-diindolylmethane, 2â€²,3-diindolylmethane, and 3,3â€²-diindolylmethane. The compounds are useful therapeutic and prophylactic treatment of bacterial infections in mammals. Methods of synthesis of the compounds are provided, as are pharmaceutical compositions containing the compounds.

专利号:US-5344924-A
优先权日:1991-02-20
标题 :Solvent-free synthesis of ethereally substituted blocked monosaccharides and the selective hydrolysis thereof
发明人：ARORA SUDERSHAN K
权利人:GREENWICH PHARMA
摘要:A solvent-free method for synthesizing an ethereally-substituted, blocked monosaccharide comprising the steps of: n 1) mixing, in the absence of solvent, a partially blocked monosaccharide unblocked at one position, an alkyl halide or a substituted alkyl halide, and an anhydrous alkali base; n 2) heating the mixture to a temperature sufficient to allow the mixture to react; n 3) maintaining the mixture at a suitable temperature for a time sufficient to form an ethereally-substituted blocked monosaccharide and drive off any water produced; n 4) removing any unreacted alkyl halide or substituted alkyl halide from the mixture; n 5) recovering the ethereally-substituted blocked monosaccharide product from the mixture; and, optionally, n 6) selectively hydrolyzing the ethereally-substituted blocked monosaccharide product to remove one or more of the acetal blocking groups.

专利号:US-2003236435-A1
优先权日:2002-05-15
标题 :Synthesis of 2-alkylcysteine via substituted thiazoline ester

专利号:US-2004082796-A1
优先权日:2002-05-15
标题 :Synthesis of substituted thiazoline carboxylic acids

专利号:US-2003229231-A1
优先权日:2002-05-15
标题:Synthesis of 2-alkylcysteine