CAS: 495-91-0; (2Z,4Z)-5-(1,3-Benzodioxol-5-yl)-1-Piperidin-1-Ylpenta-2,4-Dien-1-One

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CAS号94-62-2 胡椒碱

📜胡椒碱 反应生成 Isochavicine,胡椒脂碱
参考文献:紫外线照射影响黑素细胞刺激活性和胡椒碱的蛋白质结合
标题:紫外线照射影响黑素细胞刺激活性和胡椒碱的蛋白质结合
摘要:摘要胡椒碱是黑胡椒(piper Nigrum L.;piperaceae)的主要生物碱,在体外刺激黑色素细胞增殖和树突形成.这种特性使其成为皮肤色素脱失症白斑病的潜在治疗方法.然而,胡椒碱在体外不会刺激黑色素合成,因此基于这种化合物的治疗可能会更有效地将皮肤同时暴露在紫外线 (Uv) 辐射或阳光下.本研究调查了 Uva 和模拟太阳辐射 (Ssr) 对胡椒碱化学稳定性,黑素细胞刺激作用及其结合蛋白质和 Dna 的能力的影响.色谱和光谱分析证实了受照射胡椒碱的预期光异构化,并表明没有任何水解为胡椒酸.异构化导致丧失刺激小鼠黑素细胞系增殖和与人血清白蛋白结合的能力.在辐射之前或之后,没有胡椒碱与 Dna 结合的证据,表明胡椒碱或其几何异构体没有形成光加成物.这与补骨脂素的情况不同,补骨脂素在与 Uva 一起用于治疗皮肤病时会形成 Dna 加合物.目前的研究表明,在将胡椒碱积极应用于皮肤和储存胡椒
DOI:10.1562/2006-04-21-Ra-882

专利信息

专利号:US-2008146987-A1
优先权日:2006-12-19
标 题:Treatment of a skin condition using a piperine-based composition in conjunction with irradiation
发明人：SOUMYANATH AMALA; YOUNG ANTONY R; FAAS LAURA; VENKATASAMY RADHAKRISHNAN; HIDER ROBERT C; WALKER SUSAN
权利人:UNIV OREGON HEALTH & SCIENCE
摘要:Embodiments of the present invention are directed to methods, apparatuses, and systems for the treatment of various skin conditions by delivery of piperine and/or a related structural analog of piperine (collectively referred to as piperine-based compounds) to an area of skin affected by a skin condition (e.g., vitiligo) in conjunction with irradiation of the affected area. Structural analogs of piperine include compounds such as THP, CHP, and RCHP. In various embodiments, irradiation of affected skin in conjunction with a piperine-based composition may result in stimulation of melanin synthesis by melanocytes which may induce pigmentation to a greater extent than with the use of the piperine-based compound alone.