CAS: 475-54-7; Oosporein

上下游产品

(3Z)-3-(2,3-二羟基-4-甲基-6-氧代-1-环己-2,4-二烯亚基)-6-甲基环己-5-烯-1,2,4-三酮 Phoenicin 128-68-7
4,4'-二甲基-1,1'-联苯-2,2',5,5'-四酮 5,5'-Dimethyl-2,2'-Bis-P-Benzoquinone 02/07/4388

📜(3Z)-3-(2,3-二羟基-4-甲基-6-氧代-1-环己-2,4-二烯亚基)-6-甲基环己-5-烯-1,2,4-三酮置于四氢吡咯,Copper Diacetate,盐酸,水体系中,用59%的收率获得产物卵孢霉素
参考文献:An Efficient Synthesis Of Oosporein
标题:An Efficient Synthesis Of Oosporein
摘要:Fungal Metabolite Oosporein Was Prepared In Four Steps And 24% Overall Yield Starting From 2.5-Dimethoxytoluene. It Was Demonstrated That Treatment Of Phoenicin With Pyrrolidine And Copper(II) Acetate Led To Oosporein,Whereas Similar Treatment Of The Isomeric 'Isophoenicin' Produced A Benzofuran Diquinone. No Chromatography Was Required During Any Step Of The Synthesis. (C) 2009 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tetlet.2009.06.103

专利信息

专利号:US-5925733-A
优先权日:1995-07-14
标 题 :DNA polymerase of gamma herpes viruses associated with Kaposi's sarcoma and retroperitoneal fibromatosis
发明人：ROSE TIMOTHY M; BOSCH MARNIX L; STRAND KURT; TODARO GEORGE J
权利人:UNIV WASHINGTON
摘要:This invention provides isolated polynucleotides encoding DNA polymerases of three members of a subfamily of gamma herpes viruses. Two were obtained from macaque monkeys affected with retroperitoneal fibromatosis, the other from human AIDS patients affected with Kaposi's sarcoma. A 454-base pair fragment encoding a region near the active site of the DNA polymerase is 69-83% identical amongst the three viruses, but only 54-68% identical with other known gamma herpes sequences and <55% identical with alpha and beta herpes sequences. Also provided are polynucleotides encoding DNA polymerase from related viruses in the RFHV/KSHV subfamily. Polynucleotides prepared according to the sequence data can be used as reagents to detect and characterize related sequences. Such reagents may be used to detect members of the RFHV/KSHV subfamily, including but not limited to RFHV, RFHV2, and KSHV. Corresponding polypeptides and peptide fragments may be obtained by expressing the polynucleotide or by chemical synthesis. They may be used for detecting specific antibody potentially present in the serum of infected subjects. They may also be used for designing or screening pharmaceutical compounds that limit viral replication by inhibiting DNA polymerase activity.