专利号:US-5861532-A 优先权日:1997-03-04 标 题:Solid-phase synthesis of N-alkyl amides 发明人:BROWN EDWARD G; NUSS JOHN M 权利人:CHIRON CORP 摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.
专利号:US-6528642-B1 优先权日:1997-08-29 标题:Mono-and di-derivatives of cyclodextrins, synthesis thereof and purification and use thereof in support 发明人:DUVAL RAPHAEL; LEVEQUE HUBERT 权利人:INST FRANCAIS DU PETROLE; CHIRALSEP SARL 摘要:Mono- and di-derivatives of cyclodextrins are completely defined, also a method for their synthesis and purification, functionalised cyclodextrins obtained from these derivatives, and the synthesis of supports comprising these cyclodextrin derivatives. Use of the supports for the preparation or separation of enantiomers, for asymmetric synthesis, for catalysis, for the preparation or separation of geometrical isomers or positional isomers, or for the preparation or separation of organic molecules with a hydrophobic nature is also described.
专利号:WO-2014073003-A1 优先权日:2012-11-09 标题:Single-step process for the preparation of aryl olefins 发明人:BORATE HANUMANT BAPURAO; GAIKWAD SUPRIYA HANUMANT; KUDALE ANANDA SHAHAJI; CHAVAN SUBHASH PRATAPRAO; PHARANDE SHRIKANT GANPAT; WAGH VITTHAL DATTATRAYA; SAWANT VIKRAM SHAHAJI 权利人:COUNCIL SCIENT IND RES 摘要:The present invention relates to the single-step process for the synthesis of aryl olefin compounds of Formula (1) by reacting aryl aldehydes with alkyl aldehydes in presence of malononitrile and acid or base or salt, optionally in presence of solvent.
专利号:US-6042723-A 优先权日:1997-08-29 标 题:Mono- and di-derivatives of cyclodextrins, synthesis thereof and purification and use thereof in a support
专利号:US-9423395-B2 优先权日:2013-01-14 标 题:Fluorescent cell cycle probe having M-phase specificity 发明人:CHANG YOUNG-TAE; ZHAI DUANTING; LEE SUNG-CHAN; YUN SEONG-WOOK; JEONG YUN-MI; KANG NAM-YOUNG; PARK SUNG-JIN 权利人:NAT UNIV SINGAPORE; AGENCY SCIENCE TECH & RES 摘要:The present invention is directed to a novel family of fluorophores based on the BODIPY scaffold, and methods for their synthesis. The BODIPY-based fluorophores disclosed herein are used for the selective visualization of cells that exist in the M-phase of the cell cycle. The present invention further relates to methods for the image-based monitoring of mitotic progression in live cells.