📜溴甲烷,Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于氯仿,丙酮体系中,化学反应生成 克利溴铵 参考文献:Antispasmodics. Iii.1 Esters Of Basic Bicyclic Alcohols And Their Quaternary Salts 标题:Antispasmodics. Iii.1 Esters Of Basic Bicyclic Alcohols And Their Quaternary Salts 摘要: DOI:10.1021/ja01119A534
专利号:US-9757463-B2 优先权日:2012-06-15 标题 :Linear polyester and semi-linear glycidol polymer systems: formulation and synthesis of novel monomers and macromolecular structures 发明人:HARTH EVA M; BEEZER DAIN B; LI GUANGZHAO; SPEARS BENJAMIN R; STEVENS DAVID M 权利人:UNIV VANDERBILT 摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
专利号:US-5900227-A 优先权日:1996-06-17 标题 :Multicyclic nitrone spin trapping compositions 发明人:JANZEN EDWARD G; SANKURATRI NAGARAJU 权利人:OKLAHOMA MED RES FOUND 摘要:Multicyclic nitrone spin trapping compounds capable of forming stable free radical spin adducts are provided as well as methods for their synthesis. The multicyclic nitrone spin trapping compounds can be reacted with a free radical, such as a hydroxy or hydroperoxy radical, in solution to form a spin adduct which is stable and readily detectable by electron paramagnetic resonance (EPR) spectroscopy. The multicyclic nitrone spin traps can be used to detect free radicals in a sample such as a biological system. In one embodiment, the spin trapping compound, 1,3,3-trimethyl-6-azabicyclo-[3.2.1]oct-6-ene-N-oxide ('TRAZON') is provided, as well as methods for the synthesis of TRAZON and of modified forms of TRAZON. TRAZON can react with a wide range of different free radicals in solution to form free radical spin adducts which are readily detectable by EPR.
专利号:US-9745419-B2 优先权日:2014-01-24 标 题 :Aqueous polyglycidol synthesis with ultra-low branching 发明人:HARTH EVA M; SPEARS BENJAMIN R 权利人:UNIV VANDERBILT 摘要:Disclosed herein are glycidol-based polymers, nanoparticles, and methods related thereto useful for a variety of applications, including, but not limited to, drug delivery. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
专利号:WO-2024097977-A1 优先权日:2022-11-04 标题:Silk nanoparticle synthesis: tuning size, dispersity, and surface chemistry for drug delivery 发明人:SHAIDANI SAWNAZ; FALCUCCI THOMAS; FOSTER OLIVIA; SAHOO JUGAL KISHORE; HASTURK ONUR; KAPLAN DAVID L; JACOBUS CHARLOTTE S 权利人:TUFTS COLLEGE 摘要:Methods disclosed herein relate to generating silk nanoparticles with a low polydispersity index (PDI). Methods include adding a silk solution dropwise into a volatile solvent that is miscible with water, thereby forming a precipitate-bearing solution and applying shear forces to the precipitate-bearing solution for a length of time sufficient to achieve evaporation of at least 95% of the volatile solvent, thereby producing a population of silk fibroin nanoparticles in water having a polydispersity index (PDI) of 0.35 or less, including but not limited to, a PDI of 0.330 or less, 0.325 or less, 0.315 or less, 0.310 or less, 0.30 or less, 0.275 or less, 0.250 or less, 0.225 or less, or 0.200 or less. Parameters related to silk fibroin molecular weight, silk fibroin concentration, shear force application, and temperature may all be modified to achieve silk nanoparticles of a particular size exhibiting particular PDIs.
专利号:US-2016206743-A1 优先权日:2012-06-15 标题 :Linear Polyester and Semi-Linear Glycidol Polymer Systems: Formulation and Synthesis of Novel Monomers and Macromolecular Structures
专利号:EP-1930323-A1 优先权日:2004-03-11 标 题:Biphenyl compounds useful in the synthesis of muscarinic receptor antagonists
1: Nessim CK, Michael AM, Fayez YM, Lotfy HM. Novel Stability-Indicating Chemometric-Assisted Spectrophotometric Methods for the Determination of Chlordiazepoxide and Clidinium Bromide in the Presence of Clidinium Bromide's Alkali-Induced Degradation Product. J AOAC Int. 2018 May 1;101(3):714-722. doi: 10.5740/jaoacint.17-0096. Epub 2017 Sep 19. 189(1):67-74. doi: 10.1016/s0378-5173(99)00238-0. 74(3):461-4. 26(6):460. doi: 10.1136/emj.2008.067926. 23(1):26-9. doi: 10.1177/106002808902300104. 2013:417682. doi: 10.1155/2013/417682. Epub 2013 Feb 24. 7: Pathak A, Rai P, Rajput SJ. Stability-indicating HPLC method for simultaneous determination of clidinium bromide and chlordiazepoxide in combined dosage forms. J Chromatogr Sci. 2010 Mar;48(3):235-9. doi: 10.1093/chromsci/48.3.235. 15(7):965-71. doi: 10.1016/s0731-7085(96)01922-x. 7(2):78-81.
合成参考文献
参考文献:10.1007/s00535-005-1687-8 摘要:Hojo M, Miwa H, Yokoyama T, Ohkusa T, Nagahara A, Kawabe M, Asaoka D, Izumi Y, Sato N. Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review. J Gastroenterol. 2005 Nov;40(11):1036–42. doi: 10.1007/s00535-005-1687-8.