CAS: 32710-65-9; 2,6-Dichloroisonicotinonitrile

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113293-70-2 89281-13-0 5398-44-7

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CAS号557-21-1 氰化锌 | CAS号408492-27-3 2,6-二氯吡啶-4-硼酸频哪醇酯 | CAS号89281-13-0 2,6-二氯异烟酰胺 | CAS号5398-44-7 2,6-二氯吡啶-4-甲酸 | CAS号42521-08-4 2,6-二氯吡啶-4-羰酰氯 | CAS号2587-02-2 4-氨基-2,6-二氯吡啶 | CAS号151-50-8 氰化钾 | CAS号7719-09-7 氧氯化硫 | CAS号2464-63-3 2,6-dibromo-4-a... | CAS号408352-58-9 2,6-二溴-4-氰基吡啶 | CAS号88579-63-9 2,6-二氯吡啶-4-甲胺 | CAS号101990-69-6 2,6-二氯吡啶-4-甲醇 | CAS号175204-46-3 2,6-二氯吡啶-4-硫代酰胺 | CAS号848499-11-6 2-氯-6-(4-氧代哌啶-1...

2,6-二氯异烟酰胺置于三乙胺,三氟乙酸酐体系中,用 1,4-二氧六环 用作溶剂,以15 G的收率获得2,6-二氯-4-氰基吡啶
参考文献:一种噻嗪类饲料添加剂的制备方法
标题:一种噻嗪类饲料添加剂的制备方法
摘要:本发明公开了一种噻嗪类饲料添加剂的制备方法,属于饲料添加剂的合成技术领域.本发明的技术方案要点为:本发明与现有技术相比具有以下有益效果:本发明合成方法简单,分子结构新颖且能够作为饲料非蛋白氮,对脲酶具有一定抑制作用,并且具有杀菌抗溃疡的作用,而且无毒害作用,可作为复合饲料添加剂,有望进一步推广应用.

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-9303000-B2
优先权日:2011-01-17
标 题 :Olefin containing nuclear transport modulators and uses thereof
发明人：SANDANAYAKA VINCENT P; SHACHAM SHARON; SHECHTER SHARON; MCCAULEY DILARA
权利人:SANDANAYAKA VINCENT P; SHACHAM SHARON; SHECHTER SHARON; MCCAULEY DILARA; KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).

专利号:US-9550757-B2
优先权日:2010-03-05
标题:Nuclear transport modulators and uses thereof
发明人：SHACHAM SHARON; KAUFFMAN MICHAEL; SANDANAYAKA VINCENT P; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).