CAS: 2510-36-3; 3,5-Dimethylisoxasole-4-Carboxylic Acid

相似化合物

54593-26-9 19788-36-4 17147-42-1

上下游产品

3,5-二甲基异噁唑-4-甲酸乙脂 Ethyl 3,5-Dimethylisoxazole-4-Carboxylate 17147-42-1
(3,5-二甲基-4-异恶唑基)甲醇 4-Hydroxymethyl-3,5-Dimethylisoxazole 19788-36-4
3,4,5-三甲基恶唑 3,4,5-Trimethylisoxazole 10557-82-1

3,5-二甲基异噁唑-4-甲酸乙脂置于sodium Hydroxide体系中,化学反应生成3,5-二甲基异噁唑-4-羧酸
参考文献:Claisen,Justus Liebigs Annalen Der Chemie,1893,Vol. 277,P. 174
标题:Claisen,Justus Liebigs Annalen Der Chemie,1893,Vol. 277,P. 174

专利信息

专利号:US-7179918-B2
优先权日:2001-06-11
标 题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：CANAN KOCH STACIE S; ALEXANDER THERESE N; BURKE BENJAMIN J; JEWELL TANYA M; KUCERA DAVID J; LINTON MARIA ANGELICA; MITCHELL JR LENNERT J; REICH SIEGFRIED H; SKALITZKY DONALD J; TATLOCK JOHN H; VARNEY MICHAEL D; VIRGIL SCOTT C; WEBBER STEPHEN E; WORLAND STEPHEN T; BARVIAN MARK; BOLTON GARY; BOYER JR FREDERICK EARL; MACHAK JEFFREY J; HOLLER TOD; MURPHY SEAN T; MELNICK MICHAEL; JOSYULA VARA PRASAD
权利人:AGOURON PHARMA
摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:US-7169932-B2
优先权日:2001-06-11
标题:HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis
发明人：KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM
权利人:PFIZER
摘要:Compounds of the formula: n nwhere the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity of the HIV protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with the HIV virus. Intermediates and synthetic methods for preparing such compounds are also described.

专利号:US-7094909-B2
优先权日:2001-06-11
标 题 :HIV protease inhibitors, compositions containing the same, their pharmaceutical uses and materials for their synthesis
发明人：KUCERA DAVID JOHN; SCOTT ROBERT WILLIAM
权利人:AGOURON PHARMA
摘要:The present invention concerns processes for preparing compounds of formula (I-H), or a prodrug, pharmaceutically active metabolite, or pharmaceutically active salt or solvate thereof, n nwhich are useful as inhibitors of the HIV protease enzyme.

专利号:US-6852744-B2
优先权日:2000-08-30
标题:Pyrrolidine derivatives and their use as chymase inhibitor
发明人：DEGUCHI TAKASHI; SHIRATAKE RYOTARO; SATO FUMINORI; FUJITANI BUICHI; HONDA YAYOI; KIYOSHI AKIHIKO; NOTAKE MITSUE; SHOWELL GRAHAM ANDREW; BOYLE ROBERT GEORGE; KLAIR SUKHBINDER SINGH
权利人:DAINIPPON PHARMACEUTICAL CO
摘要:Novel pyrrolidine derivatives, being useful as chymase inhibitor or intermediate for synthesis of the active compounds, which has the formula (I): wherein R<1 >is cycloalkyl, substituted or unsubstituted phenyl or naphthyl, indanyl, thienyl, furyl, substituted or unsubstituted indolyl, benzofuryl, substituted or unsubstituted benzothienyl, etc.; R<2 >is H, alkyl, phenyl-lower alkyl, cycloalkyl or cycloalkyl-lower alkyl; R<3 >is (i) substituted or unsubstituted monocyclic heterocyclic group, (ii) substituted or unsubstituted benzene- or pyridine-fused heterocyclic group, or (iii) a group (a): R<4 >and R<5 >are independently H or OH, but R<4 >and R<5 >are not simultaneously H, or both form oxo; n is 0, 1, 2 or 3; or a salt thereof.