CAS: 1990-90-5; 3-Methylpyridin-4-Amine

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3-甲基-4-硝基吡啶-N-氧化物置于镍 氢气体系中,用 甲醇 用作溶剂,化学反应 4.0H,以95%的收率获得3-甲基-4-氨基吡啶
参考文献:抗固定的3-甲基-3-脱氮基-2'-脱氧腺苷和其他3H-咪唑并[4,5-C]吡啶类似物的合成.
标题:抗固定的3-甲基-3-脱氮基-2'-脱氧腺苷和其他3H-咪唑并[4,5-C]吡啶类似物的合成.
摘要:围绕糖苷键的杂环碱基的旋转允许在核苷中形成顺式和反式构象.主要在dna双链体中的嘌呤-嘌呤错配中观测到了顺式构象.这样的错配在基于dna的诊断中引起假阳性寡核苷酸杂交.在这里,我们描述了2'-脱氧腺苷类似物的合成,该类似物保留了其watson-Crick官能团,但不能形成syn构象.在该类似物中,2'-脱氧腺苷的n3原子被c-Ch3基团取代,得到7-甲基-1-β-D-脱氧呋喃核糖基-1H-咪唑并[4,5-C]吡啶-4-基胺或3-甲基-3-Deaza-2'-脱氧腺苷(3Mdda).这种修饰在空间上阻止了顺式构象,并且3Mdda成为2'-脱氧腺苷的抗固定核苷类似物.
Doi:10.1081/ncn-120016477

专利信息

专利号:US-7179919-B2
优先权日:2004-03-18
标 题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：SONG JINHUA J; TAN ZHULIN; YEE NATHAN K; SENANAYAKE CHRIS HUGH; XU JINGHUA; GALLOU FABRICE
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , and R 5 are as described herein.

专利号:US-7425629-B2
优先权日:2005-09-30
标 题:Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：SONG JINHUA J; REEVES JONATHAN T; ROSCHANGAR FRANK; TAN ZHULIN; YEE NATHAN K
权利人:BOEHRINGER INGELHEIM PHARMA
摘要:A process for stereoselective synthesis of a compound of Formula (I) n nwherein R 1 , R 2 , R 3 , R 4 , and R 5 are as described herein.

专利号:US-2022153699-A1
优先权日:2019-03-05
标 题:Synthesis of 4-amino-5-methyl-1h-pyridin-2(1h)-on (intermediate compound for the synthesis of the mr antagonist finerenone) from 2-chloro-5-methyl-4-nitro-pyridine-1-oxide using the intermediate compound 2-chloro-5-methyl-4-pyridinamine

专利号:US-2005209488-A1
优先权日:2004-03-18
标 题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols

专利号:US-2007100142-A1
优先权日:2005-09-30
标 题 :Stereoselective Synthesis of Certain Trifluoromethyl-Substituted Alcohols

专利号:CA-2557896-A1
优先权日:2004-03-18
标题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols