专利号:US-2009131651-A1 优先权日:2003-12-05 标题 :Synthesis of 2-substituted adenosines 发明人:BROWN GILES ALBERT; SAVORY EDWARD DANIEL; OUZMAN JACQUELINE VALERIE ANNE; STODDART ALISON MARGARET 权利人:BROWN GILES ALBERT; SAVORY EDWARD DANIEL; OUZMAN JACQUELINE VALERIE ANNE; STODDART ALISON MARGARET 摘要:Synthesis of 2-substituted adenosines of formula (I) using 2-nitro pentabenzoyl adenosine, or 2-nitro pentaacetyl adenosine, as intermediate is described: Formula (I) wherein R=C 1-6 alkoxy (straight or branched), a phenoxy group (unsubstituted, or mono-, or di-substituted by halo, amino, CF 3 —, cyano, nitro, C 1-4 alkyl, or C 1-4 alkoxy), a benzyloxy group (unsubstituted, or mono-, or di-substituted by halo, amino, CF 3 —, cyano, nitro, C 1-6 alkyl, or C 1-6 alkoxy), or a benzoyl group (unsubstituted, or mono-, or di-substituted by halo, amino, CF 3 —, cyano, nitro, C 1-6 alkyl, or C 1-6 alkoxy). The methods provide improved yield and purity of product.
专利号:WO-2024211436-A1 优先权日:2023-04-03 标题 :Rapid solution combustion synthesis of highly ordered porous metal oxide layers 发明人:COLBURN THOMAS; COLLINSON DAVID; DAUSKARDT REINHOLD; MILLER ROBERT 权利人:UNIV LELAND STANFORD JUNIOR 摘要:Fabrication of highly ordered metal oxide layers is performed by combining deposition of an oxidant-containing precursor, a pore-generating precursor, and a metal-containing precursor, depositing the precursor, and combustion of the precursor to form a metal oxide layer. In one example, high- quality porous aluminum oxide layers with controlled, 7 nm ordered porosity is demonstrated.
专利号:WO-2012152438-A1 优先权日:2011-05-11 标题 :Process for the preparation of nitrate acid ester of organic compounds 发明人:BONFANTI ANNALISA; STORONI LAURA; RONSIN GAEL 权利人:NICOX SA; BONFANTI ANNALISA; STORONI LAURA; RONSIN GAEL 摘要:The present invention relates to a one-step process for the synthesis of nitric acid esters or 15 N isotopically labeled nitrate esters of organic compounds starting from the correspondent alcohols. Formula (I).
专利号:US-9593071-B2 优先权日:2011-11-22 标题 :Process for the preparation of gamma amino acids and intermediates used in said process 发明人:ADAMO MAURO 权利人:ROYAL COLLEGE SURGEONS IRELAND 摘要:The invention relates to the preparation of gamma amino acids of formula (I) and pharmaceutically acceptable salts, solvates and prodrugs thereof, and to intermediates used for their preparation. (formula I) wherein R 1 is selected from an alkyl group, an alkenyl group, an alkynyl group and a cycloalkyl group, each of which may be optionally substituted and * denotes a chiral center. In particular, the present invention provides an efficient synthesis of (S)-pregabalin which is suitable for carrying out on an industrial scale.
专利号:EP-3567040-B1 优先权日:2013-06-24 标 题 :Method for the preparation of intermediates useful for the synthesis of [1,2,4]-triazolo[4,3-a]pyridines
专利号:US-2008262214-A1 优先权日:2003-12-05 标 题:Synthesis of 2-Substituted Adenosines
摘要:Schatz, J.; Seler, M., Science of Synthesis Knowledge Updates, (2011) 2, 389. 参考文献:10.1007/s007750050378 摘要:Bloemink MJ, Pérez JMJ, Heetebrij RJ, Reedijk J. The new anticancer drug [(2R )-aminomethylpyrrolidine](1,1-cyclobutanedicarboxylato)platinum(II) and its toxic S enantiomer do interact differently with nucleic acids. JBIC Journal of Biological Inorganic Chemistry. 1999 Oct;4(5):554–67. doi: 10.1007/s007750050378.