CAS: 1749-68-4; 6-Chloro-2-Methylpyrimidin-4-Amine

相似化合物

2166912-75-8 5305-59-9 5621-01-2

上下游产品

CAS号1780-26-3 4,6-二氯-2-甲基嘧啶 | CAS号767-16-8 4-氨基-6-羟基-2-甲基嘧啶水合物 | CAS号40497-30-1 4,6-二羟基-2-甲基嘧啶 | CAS号914347-48-1 2-(4-(6-氨基-2-甲基... | CAS号23132-67-4 6-甲氧基-2-甲基嘧啶-4-胺 | CAS号28732-85-6 2-甲基-6-N-吗啉基嘧啶-4-胺 | CAS号302964-08-5 N-(2-氯-6-甲基苯基)-... | CAS号74-69-1 2-甲基-4-氨基嘧啶 | CAS号1350918-95-4 2-甲基-4-氯-6-[双(B... | CAS号90008-43-8 (7CI)-4-氨基-6-乙基...

4,6-二羟基-2-甲基嘧啶置于甲醇,氨,三氯氧磷体系中,化学反应生成2-甲基-4-氨基-6-氯嘧啶
参考文献:Baddiley Et Al.,Journal Of The Chemical Society,1943,P. 383,384
标题:Baddiley Et Al.,Journal Of The Chemical Society,1943,P. 383,384

专利信息

专利号:US-2011281893-A1
优先权日:2010-05-11
标 题 :Compound, synthesis, composition and uses thereof
发明人：KANDULA MAHESH
权利人:KANDULA MAHESH; KRISANI BIOSCIENCES P LTD
摘要:The instant application provides the disclosure for a compound of formula I, synthesis of compound of formula I and its pharmaceutical acceptable salts, as well as its polymorphs, solvates, and hydrates thereof. The pharmaceutically acceptable salt may be formulated for oral administration, systemic administration, transdermal administration and injection. The compound of formula I and its pharmaceutical compositions may be used to treat cancer in mammal.

专利号:WO-2011095125-A1
优先权日:2010-02-02
标 题:Synthesis methods and purification methods of dasatinib
发明人：YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG
权利人:NAN JING CAVENDISH BIO ENGINEERING TECHNOLOGY CO LTD; YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG
摘要:Synthesis methods of dasatinib are provided, which comprise the following steps: reacting a compound of formula I with a compound of formula II to obtain a compound of formula III, and then connecting the compound of formula III with 2-chloro-6-methylaniline and 1-(2-hydroxyethyl)piperazine in any order to give dasatinib. Furthermore, purification methods of dasatinib are also provided.

专利号:US-9108954-B2
优先权日:2010-02-02
标 题:Synthesis process of dasatinib and intermediate thereof
发明人：YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG
权利人:YAN RONG; YANG HAO; HOU WEN; XU YONGXIANG; NAN JING CAVENDISH BIO ENGINEERING TECHNOLOGY CO LTD
摘要:Synthesis process of dasatinib is disclosed, which includes the step of reacting the compound of formula I with that of formula II to obtain the compound of formula III. Also disclosed is the compound of formula III which is used as an intermediate for synthesizing dasatinib. The substituents of R1, R2, R3 or R4 in formulae I, II or III are defined as in the description.

专利号:WO-2011095126-A1
优先权日:2010-02-02
标题:Synthesis process of dasatinib and intermediate thereof

专利号:CN-102827156-A
优先权日:2012-09-11
标 题:A new industrial synthesis method of dasatinib

专利号:US-2013030177-A1
优先权日:2010-02-02
标题:Synthesis process of dasatinib and intermediate thereof