专利号:US-11801251-B2 优先权日:2015-11-03 标 题 :Selective HDAC8 inhibitors and their uses 发明人:MEYER-ALMES FRANZ-JOSEF; MEYNERS CHRISTIAN; KLEINSCHEK ALEXANDER; HAUS PATRICIA 权利人:HOCHSCHULE DARMSTADT 摘要:The present invention relates to small molecule compounds based on benzopyrimido- or benzoimidazo-thiazin-imine as well as their (synthesis) intermediates and their use as HDAC inhibitors, in particular HDAC8 inhibitors. The present invention also relates to the use of said compounds in the treatment of cancer and as therapeutic agents for eukaryotic parasites and respective methods of treatment.
专利号:US-2013059996-A1 优先权日:2010-04-09 标 题 :Boron-Containing PI-Electron Materials Incorporating Formally Aromatic and Neutral Borepin Rings 发明人:TOVAR JOHN DAYTON; CARUSO JR ANTHONY 权利人:TOVAR JOHN DAYTON; CARUSO JR ANTHONY 摘要:The synthesis, functionalization and characterization of borepin-based extended pi-electron molecules is disclosed. Bulky substituents shielded the vacant boron p-orbitals thus allowing synthetic manipulation and purification under ambient lab conditions. The presently disclosed borepin-containing compounds displayed reversible cathodic electrochemistry and can be viewed as n-type analogues to bent acene hydrocarbons.
专利号:CN-117903053-A 优先权日:2024-01-15 标 题 :Synthesis method and application of diaryl azepine compound
专利号:CN-103275086-B 优先权日:2013-05-30 标题 :A kind of 6-substituted quinazolinoquinazolinone compound and its synthesis method and application
参考标题:Synthesis Of Phthalan Derivatives Via A Formal Intramolecular 1,3-Insertion Of Rhodium(II) Azavinyl Carbenes Into O Si Bond 作者:Shengguo Duan,Qiaoyi Xiang,Changchang Deng,Yuchen Jie,Huan Luo,Ze-Feng Xu |发布日期:2021.9 摘要:The First Formal Intramolecular 1,3-Insertion Into Osi Bond Of Rhodium(II) Azavinyl Carbene Have Been Developed, And Valuable Phthalan Derivatives Could Be Synthesized Efficiently. In Addition, Various Functional Groups Could Be Introduced To The Product Conveniently In The Assistant Of Tbaf.
合成参考文献
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 85. 摘要:Yoshikai, N.; Rayner, C. M.; Graham, M. A., Science of Synthesis Knowledge Updates, (2020) 2, 58. 摘要:Dong, X.; Liu , H., Science of Synthesis Knowledge Updates, (2019) 3, . 摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 206. 摘要:Silva, V. L. M.; Pinto, D. C. G. A.; Santos, C. M. M.; Rocha, D. H. A., Science of Synthesis Knowledge Updates, (2022) 3, 380.