CAS: 16377-00-7; 2(S)-2,7-Diamino-7-Iminoheptanoic Acid
该化合物是一种非蛋白性氨基氨酸类比亚丙烯,自然地存在于某些植物中,自然地存在于异族植物中;它具有竞争力,抑制了丙烯菊酯和氮氧化合成酶,使其成为研究丙烯新陈代谢和相关途径的宝贵工具;它的结构相似性允许它干扰依赖氨基酸的生物过程,提供对代谢紊乱和酶机制的洞察;Indospicine也有兴趣研究兽医毒理学,因为它对牲畜的肝毒性影响;它具有明确的化学特性和特性,有助于生物化学研究,特别是酶学和毒理学研究.
- 英文名称2(S)-2,7-Diamino-7-Iminoheptanoic Acid
- 中文名称穗花木兰氨酸
- IUPAC名称6-Amidino-2-aminohexanoic acid
- 其它别名Heptanoic acid,2,7-diamino-7-imino-, (S)-; Norleucine, 6-amidino-, L- (8CI); Indospicine; L-2-Amino-6-amidinohexanoic acid; L-6-Amidinonorleucine; L-Indospicine; L-a-Amino-e-amidin°Caproic acid
- CAS编号16377-00-7
- FDA UNII编号:X29Q4D9671
- 分子式:C7H15N3O2分子量:173.21
- 产品CID: 830400
- 产品分类有机原料 → 有机酸及其衍生物 → 羧酸及其衍生物
物理性质
MSDS等安全信息
合成工艺路线路线简述
📜Ethyl 2(S)-2-(Benzyloxycarbonylamino)-6-Tosyloxyhexanoate置于盐酸体系中,用 乙醇,水 用作溶剂,化学反应 2.0H,反应生成穗花木兰氨酸
参考文献:Synthesis Ofl-Indospicine
标题:Synthesis Ofl-Indospicine
摘要:Preparation Of L-Indospicine In Eight Steps By A Reaction Sequence Starting With L-Lysine.
Doi:10.1081/scc-120004860
海关参考信息
- 2905121000-正丙醇
2905130000-正丁醇
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11759496-B2
优先权日:2016-05-10
标题:Compounds and pharmaceutical use thereof in the treatment of cancer
发明人：SUSIN SANTOS A; KAROYAN PHILIPPE; MERLE-BERAL HÉLÈNE
权利人:KAROYAN PHILIPPE
摘要:The present invention relates to a compound or a pharmaceutical salt thereof comprising a hexapeptide sequence of formula (I), its method of synthesis and its use in anticancer therapy. The invention also relates to a pharmaceutical composition for use in the treatment of cancer comprising at least one soluble peptide according to the invention or at least one acid nucleic according to the invention or at least one expression vector according to the invention, or at least one host cell according to the invention and a pharmaceutically acceptable carrier.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1. Sultan S, Osborne SA, Addepalli R, Netzel G, Netzel ME, Fletcher MT. Indospicine cytotoxicity and transport in human cell lines. Food Chem. 2018 Nov 30;267:119-123. doi: 10.1016/j.foodchem.2017.08.029. Epub 2017 Aug 8. 45(3):518-527. doi: 10.1002/cbin.11321. Epub 2020 Mar 12.合成参考文献
参考文献:10.1071/bi9700831
摘要:Hegarty M, Pound A. Indospicine, a Hepatotoxic Amino Acid from Indigofera Spicat A: Isolation, Structure, and Biological Studies. 1970 Sep 01;23(4):831–42. doi: 10.1071/bi9700831.
参考文献:10.1111/evj.13415
摘要:Darby S, Sanchez LC, Mallicote MF, House AM, Plummer CE, Nadruz V, Benmoha RH, Roberts SM, Derendorf H, Silva‐Sanchez C, Claire J, MacKay RJ. Plasma l ‐indospicine and 3‐nitropropionic acid in ponies fed creeping indigo: Comparison with results from an episode of presumptive creeping indigo toxicosis. Equine Veterinary Journal. 2021 Feb 15;54(1):145–52. doi: 10.1111/evj.13415.
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