CAS: 148757-94-2; 2,5-Dioxo-1-Pyrrolidinyl 6-Quinolylcarbamate

该化合物是一种化学化合物,其独特结构包括一个丙烯菊酯环和松碱碱,其特点是一种化学化合物,其独特结构包括一个丙烯菊酯环和松碱碱.该化合物的存在表明,它可能具有周期性浸泡物的典型特性,如核生殖反应中潜在的反应反应反应.quinoline成分表明,该化合物可能具有芳香特性,有助于其稳定性和潜在的生物活动.该化合物还可能在有机溶剂中表现出溶性,这种溶性在类似的含氮的乙醇循环中很常见.其特定功能组,包括碳基和氨基基化合物,表明氢与生物目标结合和相互作用的潜力,使其对医药化学感兴趣.此外,该化合物的化学编号为148757-94-2,可以精确地识别化学数据库,促进包括药物和材料科学在内的各个领域的研究和应用.

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18342-66-0 148757-95-3 148757-98-6

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合成工艺路线路线简述

    📜6-氨基喹啉,N,N'-二琥珀酰亚胺基碳酸酯置于乙腈,水体系中,用 乙腈 用作溶剂,化学反应 0.5H,反应生成1-[(6-喹啉基氨基甲酰)氧基]-2,5-吡咯烷二酮
    参考文献:Activated Carbamates Compounds
    标题:Activated Carbamates Compounds
    摘要:本文介绍了一类新型的杂环芳香基氨基甲酸酯化合物.还公开了一种将胺基功能化合物衍生化为新型氨基甲酸酯的方法.这些衍生物可以使用荧光检测器进行检测.本文所述的组合物和方法允许检测和测量femtomole数量的胺基化合物.

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    专利信息


    专利号:WO-2023187827-A1
    优先权日:2022-03-30
    标题:A pharmaceutical composition comprising an inhibitor of glutamine synthetase enzyme to combat artemisinin resistance in malaria
    发明人：ARUN NAGARAJ VISWANATHAN; PADMANABAN GOVINDARAJAN; GHOSH SOURAV; KUNDU RAJIB; CHANDANA MANJUNATHA; ANAND ADITYA
    权利人:INST OF LIFE SCIENCES
    摘要:The present disclosure relates to a pharmaceutical composition to combat artemisinin resistance in malaria with the identification of Plasmodium falciparum (Pf) glutamine synthetase (GS) as a drug target. Pf Gs is important for maintaining asparagine levels in the parasite and promote protein synthesis. Since ART-resistant parasites undergo fitness loss in amino acid/nutrient- limiting conditions and GS levels are upregulated during ART exposure, targeting Pf GS and asparagine requirement can be harnessed to prevent ART resistance. The present disclosure also provides a method of suppressing the growth of Plasmodium falciparum and a method of treating malaria using GS inhibitors.

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    主要参考文献

    参考标题:A Methylidene Group In The Phosphonic Acid Analogue Of Phenylalanine Reverses The Enantiopreference Of Binding To Phenylalanine Ammonia-Lyases
    作者:Zsófia Bata,Renzhe Qian,Alexander Roller,Jeannie Horak,László Csaba Bencze,Csaba Paizs,Friedrich Hammerschmidt,Beáta G. Vértessy,László Poppe |发布日期:2017.6.19
    摘要:Formed Prosthetic 3,5-Dihydro-4-Methylidene-5H-Imidazol-5-One (Mio) Group. Mio Enzymes Catalyze The Stereoselective Synthesis Of α- Or β-Amino Acid Enantiomers, Making These Chemical Processes Environmentally Friendly And Affordable. Characterization Of Novel Inhibitors Enables Structural Understanding Of Enzyme Mechanism And Recognizes Promising Herbicide Candidates As Well. The Present Study Found That

    合成参考文献


    参考文献:10.1006/abio.1996.9914
    摘要:Palace GP, Phoebe CH. Quantitative determination of amino acid levels in neutral and glucosamine-containing carbohydrate polymers. Anal Biochem. 1997 Jan 15;244(2):393–403. doi: 10.1006/abio.1996.9914.
    参考文献:10.1006/abio.1996.9930
    摘要:Crimmins DL, Cherian R. Increasing the sensitivity of 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate amino acid analysis: a simple solution. Anal Biochem. 1997 Jan 15;244(2):407–10. doi: 10.1006/abio.1996.9930.
    参考文献:10.1021/jf9812533
    摘要:Sun T, Wong WH. Determination of domoic acid in phytoplankton by high-performance liquid chromatography of the 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate derivative. J Agric Food Chem. 1999 Nov;47(11):4678–81. doi: 10.1021/jf9812533.
    参考文献:10.1016/s0304-4165(99)00154-3
    摘要:Palace GP, Fitzpatrick R, Tran KV, Phoebe CH, Norton K. Determination of amino acids in diverse polymeric matrices using HPLC, with emphasis on agars and agaroses. Biochimica et Biophysica Acta (BBA) - General Subjects. 1999 Nov;1472(3):509–18. doi: 10.1016/s0304-4165(99)00154-3.
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