CAS: 14370-23-1; 2-Isothiocyanatobicyclo[2.2.1]Heptane

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CAS号498-66-8 降冰片烯 | CAS号333-20-0 硫氰酸钾 | CAS号75-15-0 二硫化碳 | CAS号7242-92-4 (1R,2R,4S)-rel-...

📜降冰片烯,Potassium Thioacyanate置于硫酸体系中,用 水,苯 用作溶剂,化学反应 5.0H,以87%的收率获得外-2-去甲冰片基异硫氰酸
参考文献:基于 1-烯丙基-3-降冰片烷-硫脲的新型硝酸铜 (I) π,σ-配位化合物的晶体结构,Dft 研究和 Nlo 性质
标题:基于 1-烯丙基-3-降冰片烷-硫脲的新型硝酸铜 (I) π,σ-配位化合物的晶体结构,Dft 研究和 Nlo 性质
摘要:这项工作是针对新型硝酸铜 (I) π,σ 配位化合物 [cu( Anor )(Ch 3 Cn)](No 3 ) ( 1 ) 基于 1-烯丙基-3-降冰片烷-硫脲(anor).在anor和1的晶体结构中,由于(2S)-Exo和(2R)-Exo对映体的叠加,有机部分是无序的.的阿诺配体1个用作桥接配体,连接的cu(i)离子注入到阳离子配位聚合物{[铜(阿诺)(ch 3 Cn)]+ } N至η 2-烯丙基和硫脲 S 原子.Anor结构中-Nh-基团的h原子参与n H...s氢键并形成无限氢键层,而1的有机金属链中相同的配体基团通过分叉的n H.连接..o 键与同一个no 3-阴离子的两个o 原子.Anor和配位化合物1的二阶非线性光学性质在由纳秒脉冲 Nd:Yag 激光产生的 1064 Nm 处进行研究.由 Dft 方法计算的平均一阶 Nlo 超极化率的相应值以及 Anor 配体分子和阳离子片段的
Doi:10.1016/j.Poly.2021.115545

专利信息

专利号:EP-1966146-B1
优先权日:2005-12-20
标题 :4,5-dihydro- (1h)-pyrazole derivatives as cannabinoid cb1 receptor modulators
发明人：LANGE JOSEPHUS H M; VAN DER NEUT MARTINA A W; VAN VLIET BERNARD J; IWEMA BAKKER WOUTER I
权利人:ABBOTT HEALTHCARE PRODUCTS BV
摘要:This invention is directed to 4,5-dihydro -(1 H)-pyrazole (pyrazoline) derivatives as cannabinoid CB1 receptor modulators, to pharmaceutical compositions containing these compounds, to methods for the preparation of these compounds, methods for preparing novel intermediates useful for their synthesis, and methods for preparing compositions. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in disorders in which CB1 receptors are involved, or that can be treated via manipulation of those receptors. The compounds have the general formula (I) wherein the symbols have the meanings given in the specification.