丁酸置于氯化亚砜体系中,用 苯 用作溶剂,化学反应 6.0H,反应生成丁酰氯 参考文献:Vanilline Alkanoates In The Synthesis Of Hexahydrobenzacridine And octahydroxanthene Derivatives 标题:Vanilline Alkanoates In The Synthesis Of Hexahydrobenzacridine And octahydroxanthene Derivatives 摘要:1,3-环己二酮与二甲基双酮在2-萘胺和香草醛酯的作用下,发生级联杂环化反应,生成了2-甲氧基-4-(烷基-11-氧代-7,8,9,10,11,12-六氢苯并[a]吖啶-12-基)和2-甲氧基-4-(烷基-1,8-二氧代-2,3,4,5,6,7,8,9-八氢-1H-咕吨-9-基)苯酯的脂肪族(C1-C4)羧酸衍生物. Doi:10.1007/s11176-005-0282-2
专利号:WO-2023280750-A1 优先权日:2021-07-09 标 题 :Synthesis of butyrate compounds 发明人:WUESTENBERG BETTINA 权利人:DSM IP ASSETS BV 摘要:The present invention relates to a synthesis of specific carotenoid butyrates as well as to new compounds and their use. Butyrate compounds are very useful compounds, either as such or as intermediates in organic synthesis.
专利号:US-11542269-B2 优先权日:2018-01-03 标 题:Prins reaction and compounds useful in the synthesis of halichondrin macrolides and analogs thereof 发明人:CHOI HYEONG-WOOK; FANG FRANCIS G 权利人:EISAI R&D MAN CO LTD 摘要:The invention provides methods utilizing Prins reaction in the preparation of compounds that may be useful as intermediates in the synthesis of halichondrin macrolides and analogs thereof. The invention also provides compounds that may be useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.
专利号:WO-2024084491-A1 优先权日:2022-10-21 标题:Process for synthesis of res metirom and its intermediates thereof 发明人:MEHTA NILESH VIPINCHANDRA 权利人:MEHTA NILESH VIPINCHANDRA 摘要:The present invention discloses a process for synthesis of Res metirom and its intermediates thereof. More particularly, the invention discloses process for synthesis of a key intermediate, 6-(4-amino, 2,6-dichlorophenoxy)4- isopropylpyridazin-3(2H)-one, of Res metirom via novel intermediate compounds of formula A. Wherein, R is selected from methyl, ethyl and propyl.
专利号:US-10913749-B2 优先权日:2015-05-07 标 题 :Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides 发明人:FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E 权利人:EISAI R&D MAN CO LTD 摘要:The invention provides methods for the synthesis of a halichondrin macrolides through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Horner-Wadsworth-Emmons olefination), catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides and methods for preparing the same.
专利号:US-11136335-B2 优先权日:2016-06-30 标题:Prins reaction and intermediates useful in the synthesis of halichondrin macrolides and analogs thereof 发明人:CHASE CHARLES E; CHOI HYEONG-WOOK; ENDO ATSUSHI; FANG FRANCIS G; KIM DAE-SHIK 权利人:EISAI R&D MAN CO LTD 摘要:The invention provides methods for the synthesis of a halichondrin macrolides or analogs thereof through a cyclization reaction strategy. The strategy of the present invention involves subjecting an intermediate to Prins reaction conditions to afford a macrolide. The invention also provides compounds useful as intermediates in the synthesis of a halichondrin macrolides or analogs thereof and methods for preparing the same.
专利号:US-9783549-B2 优先权日:2013-11-04 标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B 发明人:FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON 权利人:EISAI R&D MAN CO LTD 摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 293. 摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2018) 2, 240. 摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 116. 摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 299. 摘要:Khartulyari, A.; Maier, M. E., Science of Synthesis Knowledge Updates, (2010) 3, 74.