CAS: 139911-27-6; 3-Methyl-4-Fluorophenylboronic Acid

相似化合物

1001200-60-7 342636-66-2 762287-58-1

上下游产品

Triisopropyl borate 5-bromo-2-fluorotoluene tri-(tert-butyl)borate water 9H6C6H3FCH3NC9H6C6H3FCH3 2-(4-fluoro-3-methylphenyl)-4,4,5,5-tetramethyl[1,3,2]dioxaborolane

硼酸三异丙酯,5-溴-2-氟甲苯置于sodium Hydroxide,正丁基锂,柠檬酸体系中,用 四氢呋喃 用作溶剂,化学反应生成4-氟-3-甲基苯硼酸
参考文献:Prostaglandin Endoperoxide H Synthase Biosynthesis Inhibitors
标题:Prostaglandin Endoperoxide H Synthase Biosynthesis Inhibitors
摘要:该发明描述了式i的吡啶并酮化合物,这些化合物是环氧合酶(cox)抑制剂,特别是选择性地抑制环氧合酶-2(cox-2).Cox-2是与炎症相关的可诱导异构体,与构成性异构体环氧合酶-1(cox-1)相对,后者是许多组织中重要的"基础"酶,包括胃肠道(gi)和肾脏.这些化合物对cox-2的选择性减少了目前市售的非甾体类抗炎药(nsaids)所见到的不良胃肠道和肾脏副作用.

专利信息

专利号:US-12150934-B2
优先权日:2016-11-30
标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
发明人：SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

专利号:US-8933018-B2
优先权日:2011-02-07
标题 :Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
发明人：GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA
权利人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA; REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.

专利号:US-12428395-B2
优先权日:2019-08-01
标题 :Heterocyclic compounds as kinase inhibitor and uses thereof
发明人：PENDHARKAR DHANANJAY; RAMACHANDRAN SREEKANTH A; JADHAVAR PRADEEP S; PANPATIL DAYANAND; SAEED UZMA; KUMAR VIVEK; BIST DIPSHE
权利人:SPEROGENIX THERAPEUTICS LTD
摘要:The present disclosure relates generally to compounds useful in treatment of conditions associated with Checkpoint kinase (CHK), particularly CHK-1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against CHK-1 enzymes. Methods of treating conditions associated with excessive activity of CHK-1 enzymes with such compounds is disclosed. Uses thereof, pharmaceutical compositions, kits and method of synthesis also disclosed.