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D-Glcnac 以 苯甲醇 用作溶剂,化学反应生成苄基-2-乙酰胺基-2-脱氧-Alpha-D-吡喃葡萄糖苷
参考文献:Methods For Synthesis Of Alpha-D-Gal (1~>3) Gal-Containing Oligosaccharides
标题:Methods For Synthesis Of Alpha-D-Gal (1~>3) Gal-Containing Oligosaccharides
摘要:本发明涉及用于合成具有生物活性的二糖和三糖的试剂和方法,这些糖包括α-D-Gal(1->3)-D-Gal.特别地,本发明提供了用于溶液或固相合成α-D-半乳糖基-(1->3)-D-半乳糖及其衍生物的新试剂,中间体和工艺.在一个优选的实施例中,本发明提供了一种保护的单糖构建块,其通式为(II):其中r3是甲氧基或甲基;R1是h,苯甲酰基,特戊酰基,4-氯苯甲酰基,乙酰基,氯乙酰基,乙酰乙酰基,4-甲基苯甲酰基,苄基,3,4-亚甲二氧基苄基,4-甲氧基苄基,4-氯苄基,4-乙酰氨基苄基或4-叠氮苄基;R2是h,芴甲氧羰基(Fmoc),苯甲酰基,特戊酰基,4-氯苯甲酰基,乙酰基,氯乙酰基,乙酰乙酰基,4-甲基苯甲酰基,苄基,3,4-亚甲二氧基苄基,4-甲氧基苄基,4-氯苄基,4-乙酰氨基苄基或4-叠氮苄基.

专利信息

专利号:US-2004058888-A1
优先权日:2000-01-13
标题:Methods for synthesis of alpha-d-gal (1~>3) gal-containing oligosaccharides
发明人：BORNAGHI LAURENT; DEKANY GYULA; DRINNAN NICHOLAS BARRY; PAPAGEORGIOU JOHN; WEST MICHAEL LEO
摘要:This invention relates to reagents and methods for synthesis of biologically active di- and tri-saccharides comprising α-D-Gal(1→3)-D-Gal. In particular the invention provides novel reagents, intermediates and processes for the solution or solid phase synthesis of α-D-galactopyranosyl-(1→3)-D-galactose, and derivatives thereof. In one preferred embodiments the invention provides a protected monosaccharide building block of general formula (II): in which R 3 is methoxy or methyl; R 1 is H, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4-chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl; and R 2 is H, Fmoc, benzoyl, pivaloyl, 4-chlorobenzoyl, acetyl, chloroacetyl, levulinoyl, 4-methylbenzoyl, benzyl, 3,4-methylenedioxybenzyl, 4-methoxybenzyl, 4 -chlorobenzyl, 4-acetamidobenzyl, or 4-azidobenzyl.

专利号:US-10927147-B2
优先权日:2015-12-10
标 题:Muramyl peptide derivative compound, synthesis and uses thereof
发明人：ELLA KRISHNA MURTHY; BRUNDA GANNERU; KUMAR HALMATHUR MAHABALARAO SAMPATH; SREEKANTH MIRYALA
权利人:BHARAT BIOTECH INT LTD; COUNCIL SCIENT IND RES
摘要:The invention relates to novel Muramyl Dipeptide (MDP) derivative compound of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof. n n n n n n n n n n Wherein, R can be both linear and branched alkyl, aryl, substituted aryl and alkoxy alkyl. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are, particularly useful as adjuvants in vaccines.

专利号:US-10576147-B2
优先权日:2015-12-15
标题:Muramyl peptide derivative compound, synthesis and uses thereof
发明人：ELLA KRISHNA MURTHY; BRUNDA GANNERU; KUMAR HALMATHUR MAHABALARAO SAMPATH; SREEKANTH MIRYALA
权利人:BHARAT BIOTECH INT LTD; COUNCIL SCIENT IND RES
摘要:The invention relates to novel Muramyl Dipeptide (MDP) derivative compound of structural Formula-VIII, a process for synthesis, intermediates used in the synthesis and use thereof; n nwherein R 1 and R 2 both are hydrogen; or R 1 is hydrogen and R 2 is alkyl or aryl; or R 1 is alkyl or aryl and R 2 is hydrogen; or R 1 and R 2 both are alkyl or aryl (same or different groups); wherein alkyl group constitute C1-C6 alkyl or higher (both linear and branched) with or without heteroatoms; and aryl group constitute phenyl, substituted phenyl, heteraryl, arylalkyl and polynuclear aromatics. These compounds possess excellent pharmacological properties, in particular immunomodulating properties for use as adjuvant in vaccine formulations. These compounds are, particularly useful as adjuvants in vaccines.

专利号:EP-1257558-A1
优先权日:2000-01-13
标 题:Methods for synthesis of alpha-d-gal (1- 3) gal-containing oligosaccharides

专利号:WO-0151499-A1
优先权日:2000-01-13
标题:METHODS FOR SYNTHESIS OF α-D-GAL (1→3) GAL-CONTAINING OLIGOSACCHARIDES

专利号:AU-2654201-A
优先权日:2000-01-13
标题 :Methods for synthesis of alpha-D-GAL (1-3) GAL-containing oligosaccharides