CAS: 131833-93-7; (4S,4'S)-2,2'-(Propane-2,2-Diyl)Bis(4-(Tert-Butyl)-4,5-Dihydrooxazole)

上下游产品

2,2-dimethylmalononitrile (S)-tert-leucinol (S,S)-2,2'-methylenebis(4-tert-butyl-2-oxazoline) methyl iodide

📜二甲基丙二酸置于草酰氯,三乙胺,N,N-二甲基甲酰胺体系中,用 二氯甲烷 用作溶剂,化学反应 51.5H,反应生成(S,S)-(-)-2,2'-异亚丙基双(4-叔丁基-2-恶唑啉)
参考文献:Lewis Acid Catalysed Asymmetric One-Carbon Ring-Expansion Of Prochiral Cyclobutanones
标题:Lewis Acid Catalysed Asymmetric One-Carbon Ring-Expansion Of Prochiral Cyclobutanones
摘要:摘要:本文描述了手性β-取代环戊酮的亲核亚甲基插入反应,提供了在合成和天然产物中作为重要结构基元的手性β-取代环戊烯酮的访问途径.商业上可获得的三甲基硅基以及其他硅基重氮甲烷作为一碳合成物,而三氟甲基硫酸钪则被发现是一种有效的路易斯酸催化剂.通过使用双噁唑啉配体,实现了对许多β-取代环戊烯酮的对映诱导,包括带有全碳季节立体中心的例子.
Doi:10.1055/s-0042-1751386

专利信息

专利号:US-7186709-B2
优先权日:2002-08-27
标 题:Dihydropyrancarboxamides and uses thereof
发明人：SCHREIBER STUART L; STAVENGER ROBERT A; MITCHISON TIMOTHY J; MALIGA ZOLTAN
权利人:HARVARD COLLEGE
摘要:The present invention provides novel dihydropyrancarboxamide compounds of formula (I): n nand collections of these compounds, and provides methods for the synthesis of these compounds; wherein R 1 –R 6 are as defined herein. Additionally, the present invention provides pharmaceutical compositions and methods for treating disorders such as proliferative diseases, and cancer, to name a few.

专利号:US-8633182-B2
优先权日:2012-05-30
标题:Indanyloxyphenylcyclopropanecarboxylic acids
发明人：HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN
权利人:HAMPRECHT DIETER; FRATTINI SARA; LINGARD IAIN; PETERS STEFAN; BOEHRINGER INGELHEIM INT
摘要:The present invention relates to compounds of general formula I, n nwherein the groups R 1 , R 2 , R 3 , m and n are defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.

专利号:CN-115304568-A
优先权日:2022-05-17
标 题 :Asymmetric synthesis of 6-azidomethylene-1-aryl-3-oxabicyclo[3,1,0]hexan-2-ones

专利号:CN-114031573-A
优先权日:2022-01-10
标 题:Method for recovering ligands in asymmetric synthesis of S-(+)-2,2-dimethylcyclopropanecarboxylic acid

专利号:CN-107903276-A
优先权日:2017-11-17
标题 :A kind of asymmetric synthesis method of ring E of harringtonine skeleton

专利号:CN-107903276-B
优先权日:2017-11-17
标 题 :A kind of asymmetric synthesis method of ring E of harringtonine skeleton