CAS: 1149-26-4; Z-L-Val-Oh

相似化合物

1685-33-2 3588-63-4 103478-58-6

上下游产品

CAS号72-18-4 l-缬氨酸 | CAS号501-53-1 氯甲酸苄酯 | CAS号6216-65-5 cbz-l-缬氨醇 | CAS号394210-42-5 benzyl 4-isopro... | CAS号122665-04-7 (S)-allyl 2-(((... | CAS号24210-19-3 (S)-2-(((苄氧基)羰基... | CAS号42417-65-2 Cbz-L-N-Me-缬氨酸 | CAS号191731-16-5 (s)-4-(cbz-氨基)-... | CAS号18904-53-5 Z-Val-Trp-OH | CAS号17922-79-1 (S)-(1-(环己基氨基)-... | CAS号180968-41-6 1OH-2B°CNH-3PhP... | CAS号215608-32-5 (R)-3-(((苄氧基)羰基... | CAS号220663-44-5 1-BENZYL-2(S)-I... | CAS号20556-16-5 H-Val-Asp-OH | CAS号19542-51-9 ((苄氧基)羰基)-L-缬氨酰... | CAS号19746-19-1 Benzyloxycarbon...

3,3-Dibromo-1-(Tert-Butylamino)-1-Oxobutan-2-Yl ((Benzyloxy)Carbonyl)-L-Valinate置于酞菁钴 Sodium Metaborate体系中,用 乙醇 用作溶剂,化学反应 1.0H,以64%的收率获得cbz-L-缬氨酸
参考文献:Redox-Katalysator Kobalt-Phthalocyanin: Deblockierung Von 2-Halogenoalkyl-Verbindungen
标题:Redox-Katalysator Kobalt-Phthalocyanin: Deblockierung Von 2-Halogenoalkyl-Verbindungen
摘要:
Doi:10.1055/s-1980-29286

专利信息

专利号:US-9126896-B2
优先权日:2012-06-01
标题:Synthesis of diamido gellants by using Dane salts of amino acids
发明人：BINDL MARTIN; HERRMANN ROLAND; KNAUP GUNTER
权利人:EVONIK INDUSTRIES AG
摘要:The invention relates to a method for the synthesis of a compound according to formula I comprising the following steps: a) reacting a Dane salt according to formula II and a Dane salt according to formula III with a coupling reagent; b) adding a diamine according to formula IV to the reaction mixture; and c) adding an acid to the reaction mixture to adjust the pH value of the reaction to <7; wherein L represents a C 2 -C 20 alkyl group, a C 6 -C 20 aryl group, or a C 7 -C 20 alkylaryl group; R 1 and R 2 can be identical or different and represent a hydrogen atom, a C 1 -C 4 alkyl group, a C 1 -C 4 hydroxyalkyl group, a C 1 -C 4 thioether group, a C 6 -C 20 aryl group, a C 7 -C 20 alkylaryl group, a C 7 -C 20 alkylhydroxyaryl group, a C 4 -C 20 alkylheteroaryl group with 1 to 4 heteroatoms; or a C 1 -C 4 alkylcarboxylic moiety, which may be an acid, an amide, or which may be esterified with a C 1 -C 6 alkyl group or a C 7 -C 20 alkylaryl group; R 3 represents a C 1 -C 4 alkyl group; R 4 represents a hydrogen atom, or a C 1 -C 4 alkyl group; R 5 represents a C 1 -C 4 alkyl group; and X represents an alkali metal.

专利号:US-5554725-A
优先权日:1994-09-14
标题:Synthesis of dolastatin 15
发明人：PETTIT GEORGE R
权利人:UNIV ARIZONA
摘要:The present invention relates to the synthesis of natural (-)- dolastatin and the elucidation of the absolute configuration of this important sea hare constituent. A segment synthetic strategy was utilized for obtaining the Dolabella auricularia (Indian Ocean sea hare) depsipeptide dolastatin 15. Reaction of protected (S)-Hiva-(S)-Phe (2c) with isopropenyl chloroformate followed by Meldrum's ester, cyclization (2c→3a) of the product in toluene and finally methylation afforded the key (S)-dolapyrrolidine (Dpy) derivative (3b). Condensation of tripeptide (8) with the three unit Dpy segment (5b) followed by deprotection and coupling (diethyl phosphorocyanidate) led to dolastatin 15 in 11% overall yield. The powerful and selective activity of dolastatin 15 against the U.S. National Cancer Institute's panel of human cell lines is reported.

专利号:US-9126897-B2
优先权日:2012-06-01
标 题 :Synthesis of diamido gellants by using amino acid N-carboxyanhydrides
发明人：BINDL MARTIN; HERRMANN ROLAND; KNAUP GUNTER
权利人:EVONIK INDUSTRIES AG
摘要:The invention relates to a method for the synthesis of a compound according to formula I comprising the following steps: a) reacting a N-carboxyanhydride according to formula II and a N-carboxy-anhydride according to formula III with a diamine according to formula IV and b) adding an acid to the reaction to adjust the pH value of the reaction to <7; wherein L represents a C 2 -C 20 alkyl group, a C 6 -C 20 aryl group, or a C 7 -C 20 alkylaryl group; and R 1 and R 2 can be identical or different and represent a hydrogen atom, a C 1 -C 4 alkyl group, a C 1 -C 4 hydroxyalkyl group, a C 1 -C 4 thioether group, a C 6 -C 20 aryl group, a C 7 -C 20 alkylaryl group, a C 7 -C 20 alkylhydroxyaryl group, a C 4 -C 20 alkylheteroaryl group with 1 to 4 heteroatoms; or a C 1 -C 4 alkylcarboxylic moiety, which may be an acid, an amide, or which may be esterified with a C 1 -C 6 alkyl group or a C 7 -C 20 alkylaryl group.

专利号:US-7189849-B2
优先权日:1997-02-10
标 题:Synthesis of acyclic nucleoside derivatives
发明人：LEANNA M ROBERT; RASMUSSEN MICHAEL; HANNICK STEVEN M; TIEN JIEN-HEH J; LUKIN KIRILL A; TIAN ZHENPING; CHANG SOU-JEN; CURTY CYNTHIA B; NARAYANAN BIKSHANDARKOIL A; BELLETTINI JOHN; SHELAT BHADRA; SPITZ TIFFANY
权利人:MEDIVIR AB
摘要:Novel processes towards the synthesis of the antiviral valomaciclovir stearate in which an esterified guanine acetal is reduced to the corresponding alcohol, reacted with an activated amino acid and N-deprotected. The esterified guanine acetal is prepared from a 9-guanine derivative bearing an acyclic hydroxymethylbutylacetal. The processes are amendable to one-pot reactions.

专利号:US-4504415-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1 and desacetyl thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; STUDER ROLF; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin alpha 1 and desacetyl thymosin alpha 1 with t-Boc side chain protection and proceeding through novel intermediates is disclosed.

专利号:US-4517119-A
优先权日:1983-04-04
标题:Synthesis of thymosin α1
发明人：FELIX ARTHUR M; GILLESSEN DIETER; LERGIER WILLIAM; MEIENHOFER JOHANNES A; TRZECIAK ARNOLD
权利人:HOFFMANN LA ROCHE
摘要:An improved solution phase synthesis of thymosin α 1 and proceeding through novel intermediates is disclosed.