CAS: 104227-86-3; 2-(2-(2-Amino-9H-Purin-9-yl)Ethyl)Propane-1,3-Diol
该化合物是主要研究其治疗寄生虫病毒感染潜力的一种抗病毒化合物,是以其防治寄生虫病毒病毒(HSV)和-zoster病毒(VZV)的活动著称的双氯基洛维(VZV)的衍生物. 6-脱氧双氧基洛维的化学结构具有经修改的副链,增强了其药理特性.这种复合物具有核糖类的典型特征,包括抑制病毒DNA聚合酶的能力,从而干扰病毒复制.其行动机制包括选择性地将病毒DNA纳入,导致链条终止.该化合物的特点是其稳定性和溶剂溶性,可影响其生物利用率和治疗效力.对6-脱氧双氧基洛维的研究表明,它对于现有的抗病毒疗法具有潜在优势,包括抗药性降低,安全特征得到改善.与许多抗病毒剂一样,6-脱氧基洛维的功效和安全性也不断受到临床评估.
- 英文名称2-(2-(2-Amino-9H-Purin-9-yl)Ethyl)Propane-1,3-Diol
- 中文名称2-[2-(2-氨基-9h-嘌呤-9-基)乙基]-1,3-丙二醇
- IUPAC名称2-(2-(2-amino-9H-purin-9-yl)ethyl)propane-1,3-diol
- 其它别名2-[2-(2-Amino-9H-Purin-9-yl)Ethyl]-1,3-Propanediol; 6-Deoxy Penciclovir; Di-Desacetyl Famciclovir; 2-(2-(2-Amino-9H-Purin-9-yl)Ethyl)Propane-1,3-Diol; Famciclovir Usp Rc A; 2-[2-(2-Amino-9H-Purin-9-yl)Ethyl]Propane-1,3-Diol Hcl; 1,3-Propanediol, 2-(2-(2-Amino-9H-Purin-9-yl)Ethyl)-
- CAS编号104227-86-3
- MFCD编号:MFCD00870146
- FDA UNII编号:N8C09G1O3O
- 分子式:C10H15N5O2分子量:237.26
- 产品CID: 80670
- 产品分类Chemistry → Heterocyclic Building Blocks → Aromatic Heterocycles | Alcohols | Purines | Amines
物理性质
MSDS等安全信息
上下游产品
9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine 5-[2-(2-aminopurin-9-yl)ethyl]-2,2-dimethyl-1,3-dioxane dimethyl 2-(2-(2-aminopurine-9-yl)ethyl)malonate 2-amino-7-benzyl-1H-purin-6(7H)-one -2-purine9-4-hydroxy-3-(hydroxymethyl)but-1-yl-2-(monomethoxytrityl)aminopurine but-1-yl>-2-purine(R,S)-9-3-(hydroxymethyl)-4-(monomethoxytrityl)oxybut-1-yl-2-(monomethoxytrityl)aminopurine 9-(4-acetoxy-3-acetoxymethylbutyl)-2-aminopurine -2-aminopurine(R,S)-9-4-acetoxy-3-(hydroxymethyl)but-1-yl-2-aminopurine合成工艺路线路线简述
海关参考信息
- 2905399001-1,3-丙二醇
2905141000-异丁醇
2905499000-其他多元醇
2905590090-其他无环醇的卤化、磺化等衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2011245484-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives
专利号:WO-2011123668-A2
优先权日:2010-03-31
标 题:Stereoselective synthesis of phosphorus containing actives
专利号:EP-2752422-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives
专利号:EP-2752422-B1
优先权日:2010-03-31
标题:Stereoselective synthesis of phosphorus containing actives
专利号:EP-2552931-B1
优先权日:2010-03-31
标题:Stereoselective synthesis of phosphorus containing actives
专利号:US-8859756-B2
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives
发明人：ROSS BRUCE S; SOFIA MICHAEL JOSEPH; PAMULAPATI GANAPATI REDDY; RACHAKONDA SUGUNA; ZHANG HAI-REN
权利人:ROSS BRUCE S; SOFIA MICHAEL JOSEPH; PAMULAPATI GANAPATI REDDY; RACHAKONDA SUGUNA; ZHANG HAI-REN; GILEAD PHARMASSET LLC
摘要:Disclosed herein are phosphorus-containing actives, their use as actives for treating diseases, and a stereoselective process for preparing the same. Also disclosed herein are useful synthetic intermediates and processes for preparing the same.
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.5281/zenodo.3827487
摘要:USEPA/Office of Pesticides and Toxic Substances; Simazine: Revised Preliminary HED Chapter of the Reregistration Eligibility Decision Document (RED), Document ID: EPA-HQ-OPP-2005-0151-0023 p.17-18 (May 31, 2005). Available from, as of June 6, 2007:
参考文献:10.1124/dmd.111.040923
摘要:Sanoh S, Horiguchi A, Sugihara K, Kotake Y, Tayama Y, Ohshita H, Tateno C, Horie T, Kitamura S, Ohta S. Prediction of in vivo hepatic clearance and half-life of drug candidates in human using chimeric mice with humanized liver. Drug Metab Dispos. 2012 Feb;40(2):322–8. doi: 10.1124/dmd.111.040923.
📝 需求与反馈
尽可能描述清楚需求与问题信息
