CAS: 100286-97-3; 2-Methyl-6-Oxo-1,6-Dihydro-[3,4'-Bipyridine]-5-Carbonitrile 2-Hydroxypropanoate(1:X)

该化合物是一种主要用作急性脱血性心脏衰竭管理中的非热带和血管抑制剂的磷代谢酶-3(PDE-3)抑制剂,其行动机制包括增加细胞内环环氧甲酸酯单磷酸酯(CAMP)水平,导致心肌内抗体增强和系统血管抗药性降低;乳液制剂确保静脉注射管管的溶解性和稳定性得到提高;关键优势包括其迅速启动行动,可预测的药理动力学和对心率影响最小,使其适合在关键护理环境中提供短期的心动支持.

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    海关参考信息

    • 2905122000-异丙醇
      2905310000-1,2-乙二醇
      2905320000-1,2-丙二醇
      2905499000-其他多元醇
      2905590090-其他无环醇的卤化、磺化等衍生物
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    专利信息


    专利号:US-2024082118-A1
    优先权日:2021-05-19
    标 题:Topical compositions and methods of preparing the same
    发明人:ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION
    权利人:LANDA LABS 2012 LTD
    摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.

    专利号:US-2025144039-A1
    优先权日:2022-07-13
    标题:Compositions comprising surface modified globular nano-particles
    发明人:ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION
    权利人:LANDA LABS 2012 LTD
    摘要:There are disclosed compositions comprising core-shell nano-elements composed in their core of a water-insoluble thermoplastic compound having a molecular weight of more than 0.6 kDa and in their shell of at least one fatty amine, or a part thereof, the core-shell nano-elements having a viscosity of 107 mPa·s or less and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less. The water-insoluble thermoplastic compound can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon application of the core-shell nano-elements to a surface to be treated therewith. Methods for preparing the composition and uses thereof are also provided.
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    主要参考文献


    1: Dünnes S, Voussen B, Aue A, Groneberg K, Nikolaev V, Groneberg D, Friebe A. Phosphodiesterase 3A expression and activity in the murine vasculature is influenced by NO-sensitive guanylyl cyclase. Pflugers Arch. 2018 Jan 2. doi: 10.1007/s00424-017-2106-8. [Epub ahead of print] pii: e004483. doi: 10.1161/CIRCHEARTFAILURE.117.004483.
    4: Nwaejike N, Son AY, Patel CB, Schroder JN, Milano CA, Daneshmand MA. The Axillary Intra-Aortic Balloon Pump as a Bridge to Recovery Allows Early Ambulation in Long-Term Use: Case Series and Literature Review. Innovations (Phila). 2017 Nov/Dec;12(6):472-478. doi: 10.1097/IMI.0000000000000432. doi: 10.1186/s40748-017-0066-9. eCollection 2017. Review.
    6: Roof SR, Ueyama Y, Mazhari R, Hamlin RL, Hartman JC, Ziolo MT, Reardon JE, Del Rio CL. CXL-1020, a Novel Nitroxyl (HNO) Prodrug, Is More Effective than Milrinone in Models of Diastolic Dysfunction-A Cardiovascular Therapeutic: An Efficacy and Safety Study in the Rat. Front Physiol. 2017 Nov 10;8:894. doi: 10.3389/fphys.2017.00894. eCollection 2017.
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