CAS: 916918-84-8; 4-[2-Dimethylamino-1-(1-Hydroxycyclohexyl)Ethyl]Phenyl 4-Methylbenzoate Hydrochloride

结构式图片

MSDS等安全信息

    合成工艺路线路线简述

      📜O-去甲文拉法辛置于吡啶,盐酸体系中,用 四氢呋喃,乙醇,水 作为反应溶剂,化学反应 5.0H,反应生成 5-氨基-1,3-二苯基吡唑
      参考文献:Compounds Used For Interrupting Reuptake Of 5-Hydroxytryptamine And Norepinephrine Or Treating Diseases Such As Depression
      标题:Compounds Used For Interrupting Reuptake Of 5-Hydroxytryptamine And Norepinephrine Or Treating Diseases Such As Depression

      海关参考信息

      供应商参考报价(招募中)

      品牌试剂参考报价(招募中)

      📌 第三方产品分析报告

      ✅ COA系统入驻 | 共享模式

      主要参考文献


      1: Sakurai H, Yonezawa K, Tani H, Mimura M, Bauer M, Uchida H. Novel Antidepressants in the Pipeline (Phase II and III): A Systematic Review of the US Clinical Trials Registry. Pharmacopsychiatry. 2022 Jul;55(4):193-202. doi: 10.1055/a-1714-9097. Epub 2022 Jan 19.
      2: Mi W, Yang F, Li H, Xu X, Li L, Tan Q, Wang G, Zhang K, Tian F, Luo J, Xia J, Yuan K, Lu L, Deng J, Tian J, Zhang H. Efficacy, Safety, and Tolerability of Ansofaxine (LY03005) Extended-Release Tablet for Major Depressive Disorder: A Randomized, Double-Blind, Placebo-Controlled, Dose-Finding, Phase 2 Clinical Trial. Int J Neuropsychopharmacol. 2022 Mar 17;25(3):252-260. doi: 10.1093/ijnp/pyab074.
      3: Mi W, Di X, Wang Y, Li H, Xu X, Li L, Wang H, Wang G, Zhang K, Tian F, Luo J, Yang C, Zhou Y, Xie S, Zhong H, Wu B, Yang D, Chen Z, Li Y, Chen J, Lv S, Yi Q, Jiang Z, Tian J, Zhang H. A phase 3, multicenter, double-blind, randomized, placebo-controlled clinical trial to verify the efficacy and safety of ansofaxine (LY03005) for major depressive disorder. Transl Psychiatry. 2023 May 10;13(1):163. doi: 10.1038/s41398-023-02435-0.

      合成参考文献


      摘要:Wolff A. [Problem of occupational disability hazards]. Lebensversicher Med. 1976 May;28(3):76–7.
      📝 需求与反馈
      尽可能描述清楚需求与问题信息
      ×

      通知