CAS: 82765-47-7; 1,2-Plpc
该化合物是一个复杂的有机化合物,其独特的结构特征包括磷盐框架和多种功能组.该物质含有长的脂链,有助于其疏水性,而氢氧和氧组的存在则增强了其在极地溶剂中氢结合和溶解的可能性.三甲基氨组具有丙烯特性,因此有可能用于表面活性剂,乳化剂或药物运载系统等应用.该化合物的磷含量表明,它可能展示生物活动,可能与细胞膜发生相互作用,或影响生物化学途径.其稳定性和再活性可能受到诸如pH和温度等环境因素的影响,而这些环境因素对于其在各种领域,包括各种化合物和化合物之间的整体化学结构至关重要.
- 英文名称1,2-Plpc
- 中文名称1-棕榈酰-2-月桂酰基卵磷脂
- IUPAC名称(R)-2-(dodecanoyloxy)-3-(palmitoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
- 其它别名1-Palmitoyl-2-Lauroyl-Sn-Glycero-3-Pc; Ovrjllujkrfebg-Uuwrzzswsa-N; 1-Palmitoyl-2-Lauroyl -Sn-Glycero-3-Phosphocholine; (7R)-4-Hydroxy-N,N,N-Trimethyl-10-Oxo-7-[(1-Oxododecyl)Oxy]-3,5,9-Trioxa-4-Phosphapentacosan-1-Aminium Inner Salt 4-Oxide; Plpc; 1,2-Plpc
- CAS编号82765-47-7
- MFCD编号:MFCD00214369
- 分子式:C36H72NO8P分子量:677.95
- 产品CID: 1817918
- 产品分类有机原料 → 脂质和类脂质分子 → 甘油磷脂
物理性质
MSDS等安全信息
上下游产品
2-(1-palmitoyl-2-lauroyl-sn-glycerol)-2-oxo-1,3,2-dioxaphospholane trimethylamine 1-palmitoyl-3-triphenylmethyl-sn-glycerol 1-palmitoyl-2-lauroyl-sn-glycerol合成工艺路线路线简述
- 合成目标产物 1-Palmitoyl-2-Lauroyl-Sn-Glycero-3-Pc 主要起始原料 Hexadecanoic Acid, (2R)-3-[(2-Oxido-1,3,2-Dioxaphospholan-2-yl)Oxy]-2-[(1-Oxododecyl)Oxy]Propyl Ester (9CI) And Trimethylamine
- 250142-15-5 = 82765-47-7
反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Methanol,Chloroform,Water2.1 Reagents: Triethylamine Solvents: Benzene3.1 Solvents: Acetonitrile
标题:A New Approach To The Stereospecific Synthesis Of Phospholipids. The Use Of L-Glyceric Acid For The Preparation Of Diacylglycerols,Phosphatidylcholines,And Related Derivatives
作者:Roodsari,Farzaneh S.; Et Al
参考文献:Journal Of Organic Chemistry 日期:1999 卷标:64(21) 页码:7727-7737]
250142-22-4 = 82765-47-7
反应条件:1.1 Solvents: Acetonitrile
标题:A New Approach To The Stereospecific Synthesis Of Phospholipids. The Use Of L-Glyceric Acid For The Preparation Of Diacylglycerols,Phosphatidylcholines,And Related Derivatives
作者:Roodsari,Farzaneh S.; Et Al
参考文献:Journal Of Organic Chemistry 日期:1999 卷标:64(21) 页码:7727-7737]
6609-64-9 + 89648-22-6 = 82765-47-7
反应条件:1.1 Reagents: Triethylamine Solvents: Benzene2.1 Solvents: Acetonitrile
标题:A New Approach To The Stereospecific Synthesis Of Phospholipids. The Use Of L-Glyceric Acid For The Preparation Of Diacylglycerols,Phosphatidylcholines,And Related Derivatives
作者:Roodsari,Farzaneh S.; Et Al
参考文献:Journal Of Organic Chemistry 日期:1999 卷标:64(21) 页码:7727-7737]
32899-42-6 = 82765-47-7
反应条件:1.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Chloroform2.1 Reagents: Hydrochloric Acid Solvents: Methanol,Chloroform,Water3.1 Reagents: Triethylamine Solvents: Benzene4.1 Solvents: Acetonitrile
标题:A New Approach To The Stereospecific Synthesis Of Phospholipids. The Use Of L-Glyceric Acid For The Preparation Of Diacylglycerols,Phosphatidylcholines,And Related Derivatives
作者:Roodsari,Farzaneh S.; Et Al
参考文献:Journal Of Organic Chemistry 日期:1999 卷标:64(21) 页码:7727-7737]
16975-62-5 + 623-65-4 = 82765-47-7
反应条件:1.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Chloroform2.1 Catalysts: 4-(Dimethylamino)Pyridine Solvents: Chloroform3.1 Reagents: Hydrochloric Acid Solvents: Methanol,Chloroform,Water4.1 Reagents: Triethylamine Solvents: Benzene5.1 Solvents: Acetonitrile
标题:A New Approach To The Stereospecific Synthesis Of Phospholipids. The Use Of L-Glyceric Acid For The Preparation Of Diacylglycerols,Phosphatidylcholines,And Related Derivatives
作者:Roodsari,Farzaneh S.; Et Al
参考文献:Journal Of Organic Chemistry 日期:1999 卷标:64(21) 页码:7727-7737
📜1-棕榈酰-2-月桂酰-锡-甘油置于三乙胺体系中,用 乙腈,苯 作为反应溶剂,化学反应 32.0H,反应生成 1-棕榈酰-2-月桂酰基卵磷脂
参考文献:A New Approach To The Stereospecific Synthesis Of Phospholipids. The Use Of L-Glyceric Acid For The Preparation Of Diacylglycerols,Phosphatidylcholines,And Related Derivatives
标题:A New Approach To The Stereospecific Synthesis Of Phospholipids. The Use Of L-Glyceric Acid For The Preparation Of Diacylglycerols,Phosphatidylcholines,And Related Derivatives
摘要:A New Stereospecific Synthesis Of Phospholipid Derivatives Of 1,2-Diacyl-Sn-Glycerols Is Reported. The Synthesis Is Based On (I) The Use Of L-Glyceric Acid As The Stereocenter For Construction Of The Optically Active Phospholipid Molecule,(2) Preparation Of 3-Triphenylmethyl-Sn-Glycerol As The Key Intermediate For Sequential Introduction Of The Primary And Secondary Acyl Functions Leading To The Chiral Diglycerides,And (3) Elaboration Of The Sn-3-Phosphodiester Headgroup Via Phosphorylation Using 2-Chloro-2-Oxo-1,3,2-Dioxaphospholane,Followed By Ring Opening Of The Five-Membered Phosphorus Heterocycle With Trimethylamine,Ammonia,As Well As Oxygen And Sulfur Nucleophiles. The Sequence Has Been Shown To Be Suitable For The Preparation Of Both Symmetric And Mixed-Chain Diacylglycerols With Saturated And Unsaturated Acyl Substituents. Phospholipid Headgroups Including Phosphocholine,Phosphoethanolamine,Phosphoethanol,And Phosphoethylthioacetate Functions Have Been Prepared. Application Of The Method To The Synthesis Of Functionalized Phosphatidylcholines Has Also Been Demonstrated By Incorporating Spectroscopically Active Spin-Labeled And Fluorescent Reporter Groups Via Postsynthetic Derivatization Of Chain Terminal W-Aminoalkyl Functions Of The Acyl Substituents Of The Compounds. The Synthetic Methods Developed Have A Great Deal Of Flexibility,Providing Convenient Routes To A Wide Range Of Structurally Variable Phospholipids For Physicochemical,Enzymological,And Cell-Biological Studies.
DOI:10.1021/jo990414E
海关参考信息
- 2905122000-异丙醇
2905130000-正丁醇
2905310000-1,2-乙二醇
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📌 第三方产品分析报告
合成参考文献
参考文献:10.1074/jbc.m710422200
摘要:Zhao Y, Chen Y, Bonacci TM, Bredt DS, Li S, Bensch WR, Moller DE, Kowala M, Konrad RJ, Cao G. Identification and Characterization of a Major Liver Lysophosphatidylcholine Acyltransferase. Journal of Biological Chemistry. 2008 Mar;283(13):8258–65. doi: 10.1074/jbc.m710422200.
参考文献:10.1074/jbc.m708909200
摘要:Harayama T, Shindou H, Ogasawara R, Suwabe A, Shimizu T. Identification of a Novel Noninflammatory Biosynthetic Pathway of Platelet-activating Factor*. Journal of Biological Chemistry. 2008 Apr;283(17):11097–106. doi: 10.1074/jbc.m708909200.
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