CAS: 749864-17-3; (R)-Methyl 2-((Benzo[d][1,3]Dioxol-5-Ylmethylene)Amino)-3-(1H-Indol-3-yl)Propanoate
- 英文名称(R)-Methyl 2-((Benzo[d][1,3]Dioxol-5-Ylmethylene)Amino)-3-(1H-Indol-3-yl)Propanoate
- 中文名称他达拉非杂质35
- IUPAC名称methyl (R)-2-((benzo[d][1,3]dioxol-5-ylmethylene)amino)-3-(1H-indol-3-yl)propanoate
- 其它别名Tadalafil Impurity 35; Tadalafil Impurity 35 Dihcl; Tadalafil Impurity 41; D-Tryptophan, N-(1,3-Benzodioxol-5-Ylmethylene)-, Methyl Ester; (R,E)-Methyl 2-((Benzo[d][1,3]Dioxol-5-Ylmethylene)Amino)-3-(1H-Indol-3-yl)Propanoate; (R,E)-Methyl 2-((Benzo[d][1,3]Dioxol-5-Ylmethylene)Amino)-3-(1H-Indol-3-yl)Propanoate (Tadalafil Impurity）
- CAS编号749864-17-3
- 分子式:C20H18N2O4分子量:350.37
- 产品CID: 1741494
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
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上下游产品
piperonal (1R,3R)-methyl 1,2,3,4-tetrahydro-1-(3,4-methylenedioxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxylate methyl (1R,3R)-1-(3,4-methylenedioxyphenyl)-2-chloroacetyl-2,3,4,9-tetrahydro-9H-pyrido[3,4-b]indol-3-carboxylate (6R,12aR)-6-(benzo[d][1,3]dioxol-5-yl)-2-((R)-1-benzylpyrrolidin-3-yl)-2,3,6,7,12,12a-hexahydropyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione合成工艺路线路线简述
📜胡椒醛,D-色氨酸甲酯盐酸盐 以 甲苯 作为反应溶剂,化学反应生成 他达拉非杂质35
参考文献:Design,Synthesis And Biological Activity Of β-Carboline-Based Type-5 Phosphodiesterase Inhibitors
标题:Design,Synthesis And Biological Activity Of β-Carboline-Based Type-5 Phosphodiesterase Inhibitors
摘要:The Sar Of A Series Of Beta-Carboline Derived Type 5 Phosphodiesterase Inhibitors Has Been Explored And We Have Discovered Compounds With Excellent Levels Of Pde5 Potency And Selectivity Over Pde6. However,The Series Exhibits Low Levels Of Selectivity Over Pde11,A Phosphodiesterase With Unknown Function. (C) 2003 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0960-894X(03)00159-8
海关参考信息
- 2902300000-甲苯
2905121000-正丙醇
2907210001-间苯二酚
2912110000-甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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主要参考文献
参考标题:Improved Synthesis Of Tadalafil Using Dimethyl Carbonate And Ionic Liquids作者:Martyn J. Earle,Marco Noè,Alvise Perosa,Kenneth R. Seddon
摘要:An Improved Synthesis Of Tadalafil, A Drug For The Treatment Of Male Erectile Dysfunction, Involves The Use Of Safer Solvents And Reagents As Well As A Reduced Number Of Steps.
合成参考文献
参考DOI号:10.1039/c3ra45982a
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