CAS: 614-10-8; 4-(2-Methylphenyl)Thiosemicarbazide

上下游产品

N,N'-bis-carbothioic acid di-o-toluididehydrazine-N,N'-bis-carbothioic acid di-o-toluidide o-toluidineo-toluidine o-tolylthiourea 2-tolyl isothi°Cyanate (E)-1-(pyridin-2-ylmethylene)-4-o-tolylthiosemicarbazide o-tolyl thiosemicarbazone)pyridine-3-carbaldehyde-(4-o-tolyl thiosemicarbazone) o-tolyl thiosemicarbazone)pyridine-4-carbaldehyde-(4-o-tolyl thiosemicarbazone) o-tolylthi°Carbamoyl-carbazic acid ethyl ester3-o-tolylthi°Carbamoyl-carbazic acid ethyl ester

📜N-邻甲苯基硫脲置于一水合肼体系中,用 乙醇 作为反应溶剂,化学反应 16.0H,反应生成 4-2-甲氧基苯基-3-氨基硫脲
参考文献:Triazole Incorporated Thiazoles As A New Class Of Anticonvulsants: Design,Synthesis And In Vivo Screening
标题:Triazole Incorporated Thiazoles As A New Class Of Anticonvulsants: Design,Synthesis And In Vivo Screening
摘要:Various 3-[4-(Substituted Phenyl)-1,3-Thiazol-2-Ylamino1-4-(Substituted Phenyl)-4,5-Dihydro-1H-1,2,4-Triazole-5-Thiones (7A-T) Were Designed Keeping In View The Structural Requirements Suggested In The Pharmacophore Model For Anticonvulsant Activity. Thiazole And Triazole Moieties Being Anticonvulsants Were Clubbed Together To Get The Titled Compounds And Their In Vivo Anticonvulsant Screening Were Performed By Two Most Adopted Seizure Models,Maximal Electroshock Seizure (Mes) And Subcutaneous Pentylenetetrazole (Scptz). Two Compounds 7D And 7F Showed Significant Anticonvulsant Activity In Both The Screens With Ed50 Values 23.9 Mg/kg And 13.4 Mg/kg Respectively In Mes Screen And 178.6 Mg/kg And 81.6 Mg/kg Respectively In Scptz Test. They Displayed A Wide Margin Of Safety With Protective Index (Pi),Median Hypnotic Dose (Hd50) And Median Lethal Dose (Ld50) Much Higher Than The Standard Drugs. (C) 2010 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2009.12.062

专利信息

专利号:CN-109694391-B
优先权日:2018-12-20
标题 :A kind of platinum complex with 2-amino-5-chlorobenzophenone thiosemicarbazide as ligand and its synthesis method and application