CAS: 590-14-7; 1-Bromo-1-Propene

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CAS号3724-65-0 巴豆酸 | CAS号78-75-1 1,2-二溴丙烷 | CAS号600-30-6 2,3-二溴丁酸 | CAS号75-50-3 三甲胺 | CAS号110-86-1 吡啶 | CAS号5447-96-1 1-溴-1-硝基丙烷 | CAS号139-02-6 苯酚钠 | CAS号64-17-5 乙醇 | CAS号7732-18-5 水 | CAS号996-82-7 sodium 1,3-diet... | CAS号10602-34-3 丁烯缩醛 | CAS号10575-41-4 hex-4-yn-3-one | CAS号14602-62-1 1,1,2-三溴丙烷 | CAS号96-11-7 1,2,3-三溴丙烷 | CAS号22103-05-5 Benzene,(1-prop... | CAS号1950-58-9 2-Butenamide,N,... | CAS号119163-13-2 | CAS号637-50-3 β-甲基苯乙烯 (顺反混合物)... | CAS号636-70-4 三乙胺氢溴酸盐 | CAS号74-99-7 丙炔

📜2,3-二溴丁酸置于sodium Carbonate体系中,化学反应生成 1-溴基-1-丙烯
参考文献:Wislicenus; Langbein,Justus Liebigs Annalen Der Chemie,1888,Vol. 248,P. 325
标题:Wislicenus; Langbein,Justus Liebigs Annalen Der Chemie,1888,Vol. 248,P. 325

专利信息

专利号:US-9126995-B2
优先权日:2011-11-08
标题:Method for catalytic asymmetric synthesis of optically active isoxazoline compound and optically active isoxazoline compound
发明人：TOYAMA KEN-ICHI; MORIYAMA YUJI; MATOBA KAZUTAKA; YAOSAKA MANABU; IKEDA EITATSU
权利人:NISSAN CHEMICAL IND LTD
摘要:There is provided a method for catalytic asymmetric synthesis of optically active isoxazoline compound and an optically active isoxazoline compound. A method for catalytic asymmetric synthesis of optically active isoxazoline compound of a formula (6) including reacting an α,β-unsaturated carbonyl compound of a formula (1) and a hydroxylamine in a solvent in the presence of a base by adding a chiral phase transfer catalyst. An optically active isoxazoline compound of a formula (13) that can be synthesized by the method.

专利号:US-4749806-A
优先权日:1984-12-28
标题:Process for the synthesis of isocyanates and of isocyanate derivatives
发明人：TKATCHENKO IGOR; JAOUHARI RABIH; BONNET MICHEL; DAWKINS GORDON; LECOLIER SERGE
权利人:POUDRES & EXPLOSIFS STE NALE
摘要:The present invention relates to a process for the synthesis of isocyanates and of isocyanate derivatives. Isocyanates are obtained by reacting an organic halide with a metal cyanate in an organic medium in the presence of a catalyst consisting of a complex of nickel with at least one organic ligand, in which complex the nickel is in the zero oxidation state. A carbamate or a urea, respectively, are obtained by a subsequent reaction with a hydroxy compound or a primary or secondary amine. Isocyanates and their derivatives are used especially either as refined synthesis agents for the production of pesticides and medications, or as monomers or comonomers for the preparation of many macromolecular compounds.

专利号:US-9783549-B2
优先权日:2013-11-04
标题:Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin B
发明人：FANG FRANCIS G; KIM DAE-SHIK; CHOI HYEONG-WOOK; CHASE CHARLES E; LEE JAEMOON
权利人:EISAI R&D MAN CO LTD
摘要:The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., Homer-Wadsworth-Emmons olefination), Dieckmann reaction, catalytic Ring-Closing Olefin Metathesis, or Nozaki-Hiyama-Kishi reaction) to afford a macrocyclic intermediate. The invention also provides compounds useful as intermediates in the synthesis of eribulin or a pharmaceutically acceptable salt thereof and methods for preparing the same.

专利号:US-2011237832-A1
优先权日:2010-03-29
标 题:Synthesis of hdac inhibitors: trichostatin a and analogues
发明人：HELQUIST PAUL; SCHAUER DOUGLAS; COSNER CASEY C; ISKA VIJAYA B R; CHATTERJEE ANAMITRA; WIEST OLAF
权利人:UNIV NOTRE DAME DU LAC
摘要:Embodiments herein relate to histone deacetylaces (HDACs) and HDAC inhibitors, such as trichostatin A (TSA) and TSA analogues. Embodiments provide simple methods of synthesizing TSA and TSA analogues. These methods provide routes of synthesis of TSA and TSA analogues that enable the production of the HDAC inhibitors at lower cost and in greater quantities than previously were available.

专利号:US-4315857-A
优先权日:1979-07-20
标题 :Process for the synthesis of azobenzene compounds having a cyano group in one or both of the ortho positions of the diazo component radical
发明人：BUECHELER PAUL
权利人:SANDOZ LTD
摘要:A process for the synthesis of an azobenzene compound having a cyano group in one or both of the ortho positions of the diazo component radical comprising reacting the corresponding azobenzene compound having a chloro, bromo or iodo substituent in one or both of the ortho positions of the diazo component radical with a copper thiocyanate or copper thiocyanate-forming mixture of salts in the presence of an oxidizing agent (e.g., oxygen and sodium perborate), whereby the or at least one of the chloro, bromo and iodo substituents is replaced by a cyano group.

专利号:US-9556140-B2
优先权日:2013-01-26
标 题 :Approach for synthesis of catechins
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; RAI KUMAR SANTOSH; TRIPATHI VINAYAK; PATIL ISHWAR RAKESH
权利人:SPHAERA PHARMA PRIVATE LTD
摘要:A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.