CAS: 58042-39-0; N-Hydroxy-2,4,6-Trimethylbenzenesulfonamide

上下游产品

2-mesitylenesulphonyl chlorideN-amino-2-(1-butynyl)pyridinium mesitylenesulfonate 1-amino-2-(3-methoxy-1-propynyl)pyridinium 2,4,6-trimethyl-1-benzenesulfonate 1-Amino-5-bromouracil 3-(mesitylthio)-1H-indole

📜2,4,6-三甲基苯磺酰氯置于4-二甲氨基吡啶,盐酸羟胺体系中,用 吡啶 作为反应溶剂,化学反应 0.08H,以74%的收率获得产物n-羟基-2,4,6-三甲基苯磺酰胺
参考文献:Piloty's Acid Derivative With Improved Nitroxyl-Releasing Characteristics
标题:Piloty's Acid Derivative With Improved Nitroxyl-Releasing Characteristics
摘要:Recent Studies Have Shown That Nitroxyl (Hno) ((Hno)-H-1/(No)-N-3),Which Is The One-Electron-Reduced Form Of Nitric Oxide (No),Has Unique Biological Activities,Especially In The Cardiovascular System,And Hno-Releasing Agents May Have Therapeutic Potential. Since Few Hno Donors Are Available For Use Under Physiological Conditions,We Synthesized And Evaluated A Series Of Piloty'S Acid (Pa) Derivatives And Evaluated Their Hno-Releasing Activity Under Physiological Conditions. N-Hydroxy-2-Nitrobenzenesulfonamide (17) Was The Most Efficient Hno Donor Among Our Synthesized Pa Derivatives,Including The Lead Compound,2-Bromo-N-Hydroxybenzenesulfonamide (2). The High Hno-Releasing Activity Is Suggested To Be Due To Electronic And Steric Effects. Compound 17 May Be A Useful Tool For Biological Experiments. (C) 2013 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2013.02.062

专利信息

专利号:US-8138346-B2
优先权日:2006-08-16
标题 :Method for synthesis of 8-alkoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones
发明人：BRADBURY BARTON JAMES; WILES JASON ALLAN; HASHIMOTO AKIHIRO; WANG QIUPING; LUCIEN EDLAINE; PAIS GODWIN; KIM HA YOUNG
权利人:BRADBURY BARTON JAMES; WILES JASON ALLAN; HASHIMOTO AKIHIRO; WANG QIUPING; LUCIEN EDLAINE; PAIS GODWIN; KIM HA YOUNG; ACHILLION PHARMACEUTICALS INC
摘要:The present invention provides process for synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones of the Formula A. n nThe substituents R, R 5 , R 6 , R 7 , R 8 and R 9 are defined herein. The invention also provides novel synthetic intermediates useful in the synthesis of 8-methoxy-9H-isothiazolo[5,4-b]quinoline-3,4-diones and 8A,9-dihydro-4aH-isothiazolo[5,4-b]quinoline-3,4-diones.

专利号:US-5684195-A
优先权日:1994-07-14
标 题:Method of preparing sulfmonamides from sulfones
发明人：HUANG HORNG-CHIH; HARRING SCOTT R
权利人:SEARLE & CO
摘要:A one-pot synthesis of sulfonamides from sulfones has been developed. Conversion of sulfones to the corresponding sulfinic acid salts is followed by oxidative-amination to give the sulfonamides.

专利号:US-2008071086-A1
优先权日:2006-08-16
标 题 :Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones

专利号:US-2011213152-A1
优先权日:2006-08-16
标 题 :Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones

专利号:US-7902365-B2
优先权日:2006-08-16
标题 :Method for synthesis of 8-alkoxy-9H-isothiazolo[5,4-B]quinoline-3,4-diones

专利号:WO-2008021491-A2
优先权日:2006-08-16
标 题 :Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones