CAS: 518-29-6; (5R,5Ar,8Ar)-10-Hydroxy-5-(3,4,5-Trimethoxyphenyl)-5,8,8A,9-Tetrahydrofuro[3',4':6,7]Naphtho[2,3-D][1,3]Dioxol-6(5Ah)-One

该化合物是一种自然形成的化合物,被归类为苯酚化合物,主要来源于各种植物来源,特别是豆类家庭,该化合物展示了一系列生物活动,包括抗微生物和抗炎特性,使其对药理研究感兴趣. -Peltatin A的特征是其独特的化学结构,其中包括一个甲基氧基和一个氢氧基组,有助于其再活动以及与生物系统的互动.该化合物通常位于一个坚固的状态,在室温下,在有机溶剂中可溶解,便于从植物材料中提取,正在探索其在医药和农业中的潜在应用,特别是在开发用于治疗的天然产品方面.与许多苯丙胺化合物一样, -Peltatin A 也可能展示抗氧化性特性,这可能有助于生物系统中的氧化性压力.

英文名称(5R,5Ar,8Ar)-10-Hydroxy-5-(3,4,5-Trimethoxyphenyl)-5,8,8A,9-Tetrahydrofuro[3',4':6,7]Naphtho[2,3-D][1,3]Dioxol-6(5Ah)-One
中文名称盾叶鬼臼素
IUPAC名称(5R,5aR,8aR)-10-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one
其它别名Peltatin; (5R)-5,8,8Aβ,9-Tetrahydro-10-Hydroxy-5-(3,4,5-Trimethoxyphenyl)Furo[3',4':6,7]Naphtho[2,3-D]-1,3-Dioxol-6(5Aαh)-One; β-Peltatin A; B-Peltatin; Furo[3',4':6,7]Naphtho[2,3-D]-1,3-Dioxol-6(5Ah)-One, 5,8,8A,9-Tetrahydro-10-Hydroxy-5-(3,4,5-Trimethoxyphenyl)-, (5R,5Ar,8Ar)-; β-Peltatin; (-)-Beta-Peltatin; --Peltatin
CAS编号518-29-6
MFCD编号:MFCD01709430
FDA UNII编号:3U9W61G72Y
分子式:C22H22O8分子量:414.41
产品CID: 1508694
产品分类有机原料 → 木脂素、新木脂素和相关化合物 → 木脂素内酯

相似结构搜索
产品信息参考;;;;
InChIKey: HLBPOYVRLSXWJJ-PDSMFRHLSA-N
InChI=1S/C22H22O8/c1-25-14-5-10(6-15(26-2)20(14)27-3)17-12-7-16-21(30-9-29-16)19(23)13(12)4-11-8-28-22(24)18(11)17/h5-7,11,17-18,23H,4,8-9H2,1-3H3/t11-,17+,18-/m0/s1
计算化学: 氢键受体数8.0氢键供体数1.0可旋转键数4.0

MSDS等安全信息

上下游产品

去氧鬼臼毒素 Deoxypodophyllotoxin 19186-35-7

合成工艺路线路线简述

📜去氧鬼臼毒素置于三羟甲基氨基甲烷盐酸盐,还原型辅酶ii(Nadph)四钠盐体系中,化学反应 0.33H,反应生成盾叶鬼臼素
参考文献:Aryltetralin-Lignan Formation In Two Different Cell Suspension Cultures Of Linum Album: Deoxypodophyllotoxin 6-Hydroxylase,A Key Enzyme For The Formation Of 6-Methoxypodophyllotoxin
标题:Aryltetralin-Lignan Formation In Two Different Cell Suspension Cultures Of Linum Album: Deoxypodophyllotoxin 6-Hydroxylase,A Key Enzyme For The Formation Of 6-Methoxypodophyllotoxin
摘要:Suspension Cultures Initiated From Two Different Linum Album Seedlings Accumulate Either Podophyllotoxin (Ptox,2.6 Mg/g Dw) Or 6-Methoxypodophyllotoxin (6Mptox,5.4 Mg/g Dw) As Main Lignans. Two Molecules Of Coniferyl Alcohol Are Dimerized To Pinoresinol Which Is Converted Via Several Steps Into Deoxypodophyllotoxin (Dop) Which Seems To Be The Branching Point To Ptox Or 6Mptox Biosynthesis. Dop Is Hydroxylated At Position 7 To Give Ptox By Deoxypodophyllotoxin 7-Hydroxylase (Dop7H). In Contrast,6Mptox Biosynthesis Is Achieved By Dop Hydroxylation At Position 6 To Beta-Peltatin By The Cytochrome P450 Enzyme Deoxypodophyllotoxin 6-Hydroxylase (Dop6H). The Following Methylation To Beta-Peltatin-A-Methylether Is Catalyzed By Beta-Peltatin 6-O-Methyltransferase (Beta P6Omt) From Which 6Mptox Is Formed By Hydroxylation At Position 7 By Beta-Peltatin-A-Methylether 7-Hydroxylase (Pam7H). Dop6H And Beta P6Omt Could Be Characterized In Protein Extracts From Cell Cultures Of L. Flavum And L. Nodiflorum,Respectively,And Here In L. Album For The First Time. Dop7H And Pam7H Activities Could Not Yet Be Detected With Protein Extracts. Experiments Of Feeding Dop Together With Inhibitors Of Cytochrome P450 Depending As Well As Dioxygenase Enzymes Were Performed In Order To Shed Light On The Type Of Dop7H And Pam7H. Growth Parameters And Specific Activities Of Enzymes From The Phenylpropane As Well As The Lignan Specific Biosynthetic Pathway Were Measured During A Culture Period Of 16 Days. From The Enzymes Studied Only The Dop6H Showed A Differential Activity Sustaining The Hypothesis That This Enzyme Is Responsible For The Differential Lignan Accumulation In Both Cell Lines. (C) 2007 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Phytochem.2007.02.031