CAS: 461-55-2; Butanoate

专利信息

专利号:US-9376461-B2
优先权日:2011-06-06
标 题:Non-enzymatic synthesis of O-acetyl-ADP-ribose and analogues thereof
发明人：KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B
权利人:KOPPETSCH KARSTEN; SZCZEPANKIEWICZ BRUCE G; PERNI ROBERT B; GLAXOSMITHKLINE LLC
摘要:Provided herein is a simple, one-step, non-enzymatic synthesis of O-Acetyl-ADP-ribose (OAADPR) from NAD and sodium acetate in acetic acid. The extension of this reaction to other carboxylic acids, demonstrates that the reaction between NAD, and NAD analogs produces mixtures of the corresponding 2′- and 3′-carboxylic esters. Included are O-carboxyl-ADP-ribose compounds and corresponding methods of synthesis (e.g., O-propionyl-ADP-ribose, O-succinyl-ADP-ribose, O-malonyl-ADP-ribose), as well as non-adenosine nucleoside compounds.

专利号:US-7405313-B2
优先权日:2006-09-13
标题:Method for the synthesis of basic chromium carboxylates
发明人：VINCENT JOHN B
权利人:UNIV ALABAMA
摘要:A method for the synthesis of a chromium complex 2, [Cr 3 O(carboxylate) 6 (H 2 O) 3 ] + (2), wherein carboxylate is a substituted or unsubstituted C2-C5 alkyl carboxylate, is provided, including the step of: n heating an aqueous reaction mixture of a Cr(III) salt, a substituted or unsubstituted C2-C5 alkyl carboxylic acid and a metal hydroxide for a time period and at a temperature sufficient to generate an aqueous product mixture comprising chromium complex 2 and non-toxic byproducts.

专利号:US-8541571-B2
优先权日:2008-03-03
标题:Homogeneous synthesis of cellulose ethers in ionic liquids
发明人：MOELLMANN EUGEN; HEINZE THOMAS; LIEBERT TIM; KOEHLER SARAH
权利人:MOELLMANN EUGEN; HEINZE THOMAS; LIEBERT TIM; KOEHLER SARAH; SE TYLOSE GMBH & CO KG
摘要:The invention is directed to a simple and new method for the homogeneous synthesis of cellulose ethers. Ionic liquids are not only used as solvent, but also as reaction media for the homogeneous etherification of cellulose. The dissolved cellulose is treated with the etherification agent in the absence of organic and/or inorganic bases and in the absence and/or in the presence of moderate amounts of water. The obtained cellulose ethers show new distributions of substitution on the polymer chain, resulting in new properties and applications.

专利号:US-10604479-B2
优先权日:2013-11-18
标 题:Continuous process for the one-pot synthesis of metal salts and metal complexes
发明人：LEONARDI GIULIANO; GASPERONI GIOVANNI
权利人:VOLARE & CONNECTING LLC; LEONARDI GIULIANO; NOVUS INT INC
摘要:A continuous process is described for the one-pot synthesis of compounds, such as metal salts and metal complexes, as well as optionally for the protection of the compounds thus obtained by coating and/or impregnation with suitable compounds.

专利号:US-9024030-B2
优先权日:2012-01-13
标题 :Process for the synthesis of etoricoxib
发明人：MAO ZHENMIN; LAN TIAN; LIU LANFANG; YAN LONG; BECKER STEFAN
权利人:TIEFENBACHER ALFRED E GMBH & CO KG; SHANGHAI GOLDEN PHARMATECH CO LTD; SHANGHAI GOLDEN PHARMATECH CO LTD
摘要:The present invention relates to a process for the synthesis of the anti-inflammatory agent 5-chloro-3-(4-methanesulfonylphenyl)-6′-methyl-[2,3′]bipyridine, referred to as compound of formula (1) or etoricoxib, which is a pharmaceutically active ingredient inhibiting cyclooxygenase-2. In particular, the application concerns a novel process of making the compound of formula (1) by oxidizing a compound of formula (4).

专利号:US-8383810-B2
优先权日:2004-12-20
标题:Process for the synthesis of azetidinones
发明人：THIRUVENGADAM TIRUVETTIPURAM K; CHIU JOHN S; FU XIAOYONG; MCALLISTER TIMOTHY L
权利人:MERCK SHARP & DOHME; THIRUVENGADAM TIRUVETTIPURAM K; CHIU JOHN S; FU XIAOYONG; MCALLISTER TIMOTHY L
摘要:A process is provided for preparing azetidinones useful as intermediates in the synthesis of penems and as hypocholesterolemic agents, comprising reacting a β-(substituted-amino)amide, a β-(substituted-amino)acid ester, or a β-(substituted-amino)thiolcarbonic acid ester with a silylating agent and a cyclizing agent selected from the group consisting of alkali metal carboxylates, quaternary ammonium carboxylates, quaternary ammonium hydroxides, quaternary ammonium alkoxides, quaternary ammonium aryloxides and hydrates thereof, or the reaction product of: (i) at least one quaternary ammonium halide and at least one alkali metal carboxylate; or (ii) at least one quaternary ammonium chloride, quaternary ammonium bromide, or quaternary ammonium iodide and at least one alkali metal fluoride, wherein a quaternary ammonium moiety of the cyclizing agent is unsubstituted or substituted by one to four groups independently selected from the group consisting of alkyl, arylalkyl and arylalkyl-alkyl.