CAS: 446-59-3; 2-Bromo-1-Fluoro-3-Methoxybenzene

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CAS号456-49-5 间氟苯甲醚 | CAS号641-49-6 3-氟-2-硝基苯甲醚 | CAS号446-61-7 2-氟-6-甲氧基苯胺 | CAS号443-81-2 2-溴-3-氟苯酚 | CAS号89883-22-7 Benz(e)acephena...

间氟苯甲醚置于正丁基锂,溴体系中,用 四氢呋喃,Hexanes 作为反应溶剂,化学反应 0.42H,以57%的收率获得产物2-溴-3-氟苯甲醚
参考文献:Piperazine-And Piperidine-Derivatives As Melanocortin Receptor Agonists
标题:Piperazine-And Piperidine-Derivatives As Melanocortin Receptor Agonists
摘要:本发明涉及公式i的黑素皮质素受体激动剂,可用于治疗肥胖症,糖尿病以及男性和/或女性性功能障碍.

专利信息

专利号:US-7884125-B2
优先权日:2008-04-30
标 题:Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues
发明人：STEVENS CHRISTIAN; HEUGEBAERT THOMAS
权利人:UNIV GENT
摘要:The present invention relates to a group of substituted-7-azabicyclo-[2.2.1]heptyl derivatives with biological activity. The present invention also relates to synthetic methods for producing said substituted-7-azabicyclo-[2.2.1]heptyl derivatives. The present invention also relates to certain intermediates for producing such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as a synthetic method for producing such intermediates. The present invention also relates to pharmaceutical compositions comprising such substituted-7-azabicyclo-[2.2.1]heptyl derivatives, as well as their use as medicaments for the treatment of diseases mediated by a Nicotinic Acetylcholine Receptor or a receptor being a member of the Neurotransmitter-gated Ion Channel Superfamily, such as pain, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy and nicotine addiction.

专利号:US-2009275616-A1
优先权日:2008-04-30
标 题 :Straightforward entry to 7-azabicyclo[2.2.1]heptane-1-carbonitriles and subsequent synthesis of epibatidine analogues

专利号:US-2024116909-A1
优先权日:2021-01-12
标题 :Novel compounds useful as sting agonists and uses thereof
发明人：YE YANG; LI XIUWEI; YANG GUIQUN; YAN FASHUN; WANG YANPING; LONG WEI
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Compounds of general Formula I, II, III, IV, V and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.

专利号:US-2025026766-A1
优先权日:2022-01-12
标题 :Thiazolopyridyl Amide Derivatives as DNA Polymerase Theta Inhibitors
发明人：LI JING; XU WENQING; WANG ZHIWEI
权利人:BEIGENE LTD
摘要:The present invention relates to compounds containing thiazolopyridyl amide structure, the process for their synthesis, as well as the use of such compounds for inhibiting DNA Polymerase Theta (Pol Theta), and in the treatment of various diseases including cancers.

专利号:US-2025108123-A1
优先权日:2021-12-17
标 题:Compound-linker constructs comprising novel compounds useful as sting agonists and uses thereof
发明人：YE YANG; LI XIUWEI; YANG GUIQUN; WANG HONGLING; FANG XIONG; CUI YANKAI; YAN FASHUN; SONG BINHUA
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Provided herein are compound-linker constructs and antibody-drug-conjugates of compounds of formula (Y-1), (Y-2), (Y-3), (A), (B), (C), I, II, III, IV or V that are useful as modulators of STING (Stimulator of Interferon Genes). Also provided are synthesis, compositions and uses of such compound-linker constructs and antibody-drug-conjugates.