📜4-(甲砜基)苄胺盐酸盐置于potassium Carbonate体系中,用 水 作为反应溶剂,化学反应生成 4-甲基苯硫酸氢氯酸嘧啶 参考文献:Methods And Compositions For Treating Amyloid-Related Diseases 标题:Methods And Compositions For Treating Amyloid-Related Diseases 摘要:描述了用于治疗或预防与淀粉样蛋白相关疾病的方法,化合物,药物组合物和试剂盒.
专利号:US-6906046-B2 优先权日:2000-12-22 标题 :Pharmaceutical uses and synthesis of benzobicyclooctanes 发明人:JACKSON RANDY W; DARWISH IHAB; BAUGHMAN TED A; HOWBERT J JEFFRY 权利人:CELLTECH R & D INC 摘要:Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual compounds.
专利号:US-9908876-B2 优先权日:2009-11-05 标 题:Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same 发明人:MILLER MARVIN J; MORASKI GARRETT C; MARKLEY LOWELL D; DAVIS GEORGE E 权利人:UNIV NOTRE DAME DU LAC 摘要:Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using same. Disclosed herein are various imidazo[1,2-a]pyhdine compounds and methods of using the novel compounds to treat or prevent tuberculosis in a subject or to inhibit fungal growth on plant species. Other embodiments include methods of synthesizing imidazo[1,2-a]pyridine compounds, such as the disclosed imidazo[1,2-a]pyridine compounds.
专利号:US-9856218-B2 优先权日:2013-03-15 标题:Inhibitors of PRMT5 and methods of their use 发明人:BAIOCCHI ROBERT A; LI CHENGLONG; LAI HONGSHAN; SIF SAID 权利人:OHIO STATE INNOVATION FOUNDATION 摘要:In one aspect, the invention relates to PRMT5 inhibitors, including optionally substituted N-alkyl-9H-carbazole analogs, derivatives thereof, and related compounds; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation and benign hematologic diseases using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
专利号:TW-I516474-B 优先权日:2013-05-27 标 题 :Synthesis of good ginger compounds and their analogues
专利号:US-2003069305-A1 优先权日:2000-12-22 标题:Pharmaceutical uses and synthesis of benzobicyclooctanes
专利号:TW-201512167-A 优先权日:2013-05-27 标题 :Synthesis of good ginger compounds and their analogues
参考文献:10.1023/a:1009696618386 摘要:Slade RM, Phillips MA, Berger JG. Application of an almost traceless linker in the synthesis of 2-alkylthiobenzimidazole combinatorial libraries. Mol Divers. 1998;4(4):215–9. doi: 10.1023/a:1009696618386.