CAS: 364794-58-1; 1-(5-Bromopyridin-2-yl)-4-Methylpiperazine

该化合物是一种化学化合物,其独特结构包括一个由5-溴和甲基组组成的管子环,该化合物通常具有芳香和脂类系统相关特性,有助于其潜在的生物活动;溴原子的存在增强了其反应性,并可能影响其与生物目标的相互作用;氟环因其在各种药理应用中的作用而闻名于世,由于它能够形成氢联结并与受体相互作用,在药物设计中往往充当一个脚架;此外,该化合物可能在极地溶剂中表现出溶性,这种溶剂对管子衍生物很常见;其分子结构表明,在医药化学中,特别是在针对...

结构式图片

相似化合物

153747-97-8 1187385-94-9 364794-57-0

物理性质

MSDS等安全信息

上下游产品

1-methyl-piperazine 2,5-dibromopyridine 5-bromo-2-fluoropyridine 5-bromo-2-chloropyridine 1-methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine 2-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-10-(3-(trifluoromethyl)phenyl)pyrido[3,2-c][1,5] naphthyridin-9(10H)-one 6-methyl-N-(4-{4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl}-1,3-thiazol-2-yl)pyridin-2-amine N-(4-{4-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]phenyl}thiazol-2-yl)cyclopropanecarboxamide

合成工艺路线路线简述

    📜N-甲基哌嗪,5-溴-2-氯吡啶置于1,1'-Bis[bis(Dimethylamino)Phosphino]Ferrocene,Bis(Dibenzylideneacetone)-Palladium(0),Sodium T-Butanolate体系中,用 1,4-二氧六环 用作溶剂,化学反应 15.0H,以62%的收率获得1-(5-溴吡啶-2-基)-4-甲基哌嗪
    参考文献:与多卤代吡啶在pd催化的胺化中反转常规化学选择性
    标题:与多卤代吡啶在pd催化的胺化中反转常规化学选择性
    摘要:报道了一种能够在pd催化的3,2-和5,2-Br / Cl-吡啶的胺化反应中实现选择性氯化物官能化的新型催化剂体系.利用配体参数化的反应优化策略导致鉴定出1,1'-双[双(二(二甲基氨基)膦基]二茂铁" Dmapf",一种易于获得但尚未使用的二膦,作为该转化的独特有效配体.
    Doi:10.1021/jacs.7B05409

    海关参考信息

    专利信息


    专利号:US-2007275968-A1
    优先权日:2004-09-07
    标 题 :Substituted Biphenyl Derivative
    发明人：KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
    权利人:KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
    摘要:The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: n nwherein n R 1 represents a C 6 -C 10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C 1 -C 6 alkyl)amino group, a di-(C 1 -C 6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C 1 -C 6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R 2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R 3 represents a C 1 -C 6 alkyl group, and so on; and R 4 represents a C 1 -C 6 alkyl group, and so on.

    其他信息查阅

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    实用工具

    ⚠️全国化工行业净网倡议书
    📋制造商识别码
    📖 海关编码查询
    📝MSDS生成器

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献

    参考DOI号:10.1021/ol0357696
    📝 需求与反馈
    尽可能描述清楚需求与问题信息
    ×

    通知