CAS: 3392-12-9; Boc-Val-Osu

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130878-68-1 3496-11-5 4467-55-4

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CAS号6066-82-6 N-羟基琥珀酰亚胺 | CAS号13734-41-3 B°C-L-缬氨酸 | CAS号107960-02-1 N-(1,2,2,2-四氯乙氧... | CAS号72-18-4 l-缬氨酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号79069-14-0 N-B°C-L-缬氨醇 | CAS号23361-28-6 N-[(1,1-二甲基乙氧基)... | CAS号75957-53-8 ENALAPRIL | CAS号79069-51-5 (S)-(3-甲基-1-氧代丁... | CAS号3918-94-3 缬氨酰-缬氨酸

L-缬氨酸置于n,N'-二环己基碳二亚胺体系中,化学反应生成 Boc-L-缬氨酸羟基琥珀酰亚胺酯
参考文献:某些含硫二肽和缬氨酰缬氨酸的银(i)配合物的形成常数
标题:某些含硫二肽和缬氨酰缬氨酸的银(i)配合物的形成常数
摘要:已经确定了在25oc和i = 0.10 Mol Dm-3(kno 3)时的形成常数,其中包括具有九个二肽的ag I配合物,这些二肽结合了含有一个(糖基蛋氨酸和蛋氨酸基甘氨酸)或两个硫供体原子的侧链. .在从相同的氨基酸和不同手性的形成在后一种情况下二肽进行了研究(例如,大号-Methionyl-大号-甲硫氨酸和大号-Methionyl-D蛋氨酸).将结果与缬氨酰缬氨酸进行比较.形成常数的值根据二肽的优选构象和ag的趋势来解释i与s-供体原子键合或通过形成二聚体配合物进行线性配位.
DOI:10.1039/dt9840002305

专利信息

专利号:US-6887887-B2
优先权日:2001-03-19
标 题:Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor
发明人：BORNMANN WILLIAM G; SIROTNAK FRANCIS; SCHER HOWARD; VIDAL EPHRAIM; BORELLA CHRISTOPHER; SCHEINBERG DAVID
权利人:SLOAN KETTERING INST CANCER
摘要:The present invention provides methods for the asymmetric synthesis of (S,S,R)-(−)-actinonin and its analogs and the compounds thereby synthesized having a structural formula: n n nwhere R 1 is an optionally substituted or halogenated alkyl, aryl, heteroalkyl or heteroaryl amine, said R 1 further comprising a cyclic or bicyclic structure; R 2 is methyl, CH 2 CH 3 , (CH 2 ) 2 CH 3 , C(CH 3 ) 3 , phenyl, 3,4-dichlorophenyl, biphenyl, benzyl, 4-hydroxybenzyl, piperidine, N-Boc-4-piperidine, CH 2 -(N-Boc-4-piperidine), 4-tetrahydropyran, CH 2 -4-tetrahydropyran, 3-methyl indolyl, 2-naphthyl, 3-pyridyl, 4-pyridyl, 3-thienyl; R 3 is R 2 or C 3-8 alkyl, R 4 is C 1-3 alkyl; and R 5 is NH 2 , OH, NHOH, NHOCH 3 , N(CH 3 )OH, N(CH 3 )OCH 3 , NHCH 2 CH 3 , NH(CH 2 CH 3 ), NHCH 2 (2,4-(OCH3) 2 Ph, NHCH 2 (4-NO 2 )Ph, NHN(CH 3 ) 2 , proline, or 2-hydroxymethyl pyrrolidine. Additionally, a method for the treatment of a neoplastic disease or for the inhibition of tumor cell growth each comprising the step of administering to an individual in need of such treatment a pharmacologically effective dose of the compounds of the present invention are provided.

专利号:US-2005272667-A1
优先权日:2001-03-19
标题:Analogs and derivatives of (S,S,R)-(-)-actinonin and uses therefor
发明人：SCHEINBERG DAVID; BORNMANN WILLIAM G; SIROTNAK FRANCIS; SCHER HOWARD; VIDAL EPHRAIM; BORELLA CHRISTOPHER
权利人:SCHEINBERG DAVID; BORNMANN WILLIAM G; SIROTNAK FRANCIS; SCHER HOWARD; VIDAL EPHRAIM; BORELLA CHRISTOPHER
摘要:The present invention provides analog and derivative compounds of (S,S,R)-(−)-actinonin and methods of asymmetric synthesis thereof having a structure: n n nwhere R 1 is hydrogen, C(O)R 6 or R 1 in combination with N is 2-oxomorpholine, R 2 is hydrogen, methyl, CH 2 CH(CH 3 ) 2 , (CH 2 ) 2 CH 3 , CH(CH 3 ) 2 , (CH 2 ) 3 CH 3 , (CH 2 ) 4 NH 2 , (CH 2 ) 3 CO 2 H, phenyl, 3,4-dichlorophenyl, biphenyl, benzyl, 4-hydroxybenzyl, piperidine, N-Boc-4-piperidine, CH 2 -(N-Boc-4-piperidine), 4-tetrahydropyran, CH 2 -4-tetrahydropyran, 3-methyl indolyl, 2-naphthyl, 3-pyridyl, 4-pyridyl, 3-thienyl, R 3 is R 2 or C 3-8 alkyl, R 4 is C 1-3 alkyl, R 5 is NH 2 , OH, NHOH, NHOCH 3 , N(CH 3 )OH, N(CH 3 )OCH 3 , NHCH 2 CH 3 , NH(CH 2 CH 3 ), NHCH 2 (2,4-(OCH 3 ) 2 Ph, NHCH 2 (4-NO 2 )Ph, NHN(CH 3 ) 2 , proline, or 2-hydroxymethyl pyrrolidine and R 6 is an optionally substituted or halogenated alkyl, aryl, heteroalkyl or heteroaryl amine where R 6 further comprising a cyclic or bicyclic structure. Also provided are methods for treating a neoplastic disease or for inhibiting tumor cell growth using the compounds present invention or using the compound (S,S,R)-(−)-actinonin.

专利号:US-2002198156-A1
优先权日:2001-03-19
标 题 :Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor

专利号:US-2004019083-A1
优先权日:2001-03-19
标 题:Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor

专利号:US-3705887-A
优先权日:1968-10-09
标题:Cyclic decapeptides and methods of synthesizing the same
发明人：WIELAND THEODOR; KONZ WILHELM; FAESEL JURGEN; LEWALTER JURGEN
权利人:BOEHRINGER SOHN INGELHEIM
摘要:THE COMPOUNDS ARE DERIVATIVES OF ANTAMANIDE, AND THEIR SYNTHESIS INVOLVES THE CYCLIZATION OF THE CORRESPONDING ACYCLIC DECAPEPTIDE.

专利号:EP-1372692-A4
优先权日:2001-03-19
标 题 :ASYMMETRIC SYNTHESIS OF (S, S, R) - (-) - ACTINONE AND ITS ANALOG AND USES THEREOF